ENTRY       sly04146                    Pathway
NAME        Peroxisome - Solanum lycopersicum (tomato)
DESCRIPTION Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP sly04146  Peroxisome
DBLINKS     GO: 0005777
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101266867  peroxisome biogenesis protein 16 isoform X1 [KO:K13335]
            101248207  peroxisome biogenesis protein 16 [KO:K13335]
            101251367  peroxisome biogenesis protein 3-2 [KO:K13336]
            101245440  peroxisome biogenesis protein 3-2 [KO:K13336]
            101252997  peroxisome biogenesis protein 19-2 [KO:K13337]
            101248290  peroxisome biogenesis protein 1 isoform X1 [KO:K13338]
            101250222  peroxisome biogenesis protein 6 [KO:K13339]
            543864  peroxisomal targeting signal type 2 receptor [KO:K13341]
            101251822  peroxisome biogenesis protein 5 [KO:K13342]
            101246234  peroxisomal membrane protein PEX14 isoform X1 [KO:K13343]
            101253196  peroxisomal membrane protein PEX14 isoform X2 [KO:K13343]
            101254098  peroxisomal membrane protein 13 [KO:K13344]
            101252586  peroxisome biogenesis protein 12 [KO:K13345]
            101249636  peroxisome biogenesis factor 10 [KO:K13346]
            101251298  peroxisome biogenesis protein 2 [KO:K06664]
            101248304  peroxisomal membrane protein PMP22 [KO:K13347]
            101248834  peroxisomal membrane protein PMP22 [KO:K13347]
            101252154  peroxisomal membrane protein PMP22 isoform X1 [KO:K13347]
            101260803  protein sym-1 isoform X3 [KO:K13347]
            101243643  PXMP2/4 family protein 4 [KO:K13348]
            101261915  protein SYM1-like [KO:K13348]
            101259677  protein SYM1 [KO:K13348]
            101251251  protein Mpv17 [KO:K13348]
            101257154  protein SYM1 [KO:K13348]
            101248537  PXMP2/4 family protein 4-like [KO:K13348]
            101247444  uncharacterized protein LOC101247444 [KO:K13348]
            101266138  protein Mpv17 [KO:K13348]
            101246915  peroxisomal nicotinamide adenine dinucleotide carrier [KO:K13354]
            101256779  peroxisomal nicotinamide adenine dinucleotide carrier [KO:K13354]
            101264774  2-hydroxyacyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
            101249915  phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
            101265227  acyl-coenzyme A oxidase 2, peroxisomal [KO:K00232] [EC:1.3.3.6]
            101243641  acyl-coenzyme A oxidase 3, peroxisomal-like isoform X1 [KO:K00232] [EC:1.3.3.6]
            101248057  acyl-coenzyme A oxidase 4, peroxisomal [KO:K00232] [EC:1.3.3.6]
            101250354  acyl-coenzyme A oxidase 4, peroxisomal isoform X2 [KO:K00232] [EC:1.3.3.6]
            778201  Acx1B; peroxisomal acyl-CoA oxidase 1B [KO:K00232] [EC:1.3.3.6]
            778338  Acx1A; peroxisomal acyl-CoA oxidase 1A [KO:K00232] [EC:1.3.3.6]
            101262853  3-ketoacyl-CoA thiolase 2, peroxisomal [KO:K07513] [EC:2.3.1.16]
            101255924  3-ketoacyl-CoA thiolase 2, peroxisomal [KO:K07513] [EC:2.3.1.16]
            101254404  peroxisomal 2,4-dienoyl-CoA reductase [KO:K13237] [EC:1.3.1.124]
            101255297  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal [KO:K12663] [EC:5.3.3.21]
            101260717  ABC transporter D family member 1 [KO:K25819] [EC:7.6.2.4]
            101255032  long chain acyl-CoA synthetase 6, peroxisomal-like isoform X1 [KO:K01897] [EC:6.2.1.3]
            101259379  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            101262955  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
            101257097  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            101249020  probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3]
            101268145  long chain acyl-CoA synthetase 6, peroxisomal [KO:K01897] [EC:6.2.1.3]
            101244443  long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
            101264646  long chain acyl-CoA synthetase 8-like [KO:K01897] [EC:6.2.1.3]
            101246995  LOW QUALITY PROTEIN: long chain acyl-CoA synthetase 8-like [KO:K01897] [EC:6.2.1.3]
            101246288  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
            101255334  long chain acyl-CoA synthetase 6, peroxisomal isoform X3 [KO:K01897] [EC:6.2.1.3]
            101259176  long chain acyl-CoA synthetase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
            101254843  nudix hydrolase 15, mitochondrial [KO:K17879] [EC:3.6.1.-]
            101255142  nudix hydrolase 22, chloroplastic-like isoform X1 [KO:K17879] [EC:3.6.1.-]
            101263821  nudix hydrolase 19, chloroplastic isoform X1 [KO:K03426] [EC:3.6.1.22]
            101255253  LOW QUALITY PROTEIN: malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
            101255461  alcohol-forming fatty acyl-CoA reductase-like [KO:K13356] [EC:1.2.1.84]
            101254867  probable fatty acyl-CoA reductase 4 [KO:K13356] [EC:1.2.1.84]
            101255165  fatty acyl-CoA reductase 3-like isoform X1 [KO:K13356] [EC:1.2.1.84]
            101255436  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
            101260757  fatty acyl-CoA reductase 2-like [KO:K13356] [EC:1.2.1.84]
            101267260  fatty acyl-CoA reductase 2-like isoform X1 [KO:K13356] [EC:1.2.1.84]
            101262598  fatty acyl-CoA reductase 2 [KO:K13356] [EC:1.2.1.84]
            101249557  probable fatty acyl-CoA reductase 4 isoform X1 [KO:K13356] [EC:1.2.1.84]
            101250126  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            101260469  fatty acyl-CoA reductase 2-like isoform X1 [KO:K13356] [EC:1.2.1.84]
            101261961  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
            101055519  Hop-interacting protein THI032 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            101268602  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101255848  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101248445  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
            101265751  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            101263871  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            101259975  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
            101256164  peroxisomal (S)-2-hydroxy-acid oxidase GLO4 isoform X2 [KO:K11517] [EC:1.1.3.15]
            101255570  peroxisomal (S)-2-hydroxy-acid oxidase GLO4 isoform X1 [KO:K11517] [EC:1.1.3.15]
            101255867  peroxisomal (S)-2-hydroxy-acid oxidase GLO4 [KO:K11517] [EC:1.1.3.15]
            101246162  (S)-2-hydroxy-acid oxidase GLO1 isoform X2 [KO:K11517] [EC:1.1.3.15]
            100134875  GLO2; glycolate oxidase [KO:K11517] [EC:1.1.3.15]
            544106  peroxisomal (S)-2-hydroxy-acid oxidase GLO1 [KO:K11517] [EC:1.1.3.15]
            101259333  catalase isozyme 3 [KO:K03781] [EC:1.11.1.6]
            543990  cat1; catalase isozyme 1 [KO:K03781] [EC:1.11.1.6]
            543585  CAT2; catalase isozyme 2 [KO:K03781] [EC:1.11.1.6]
            101264296  superoxide dismutase [Cu-Zn] 2 isoform X1 [KO:K04565] [EC:1.15.1.1]
            544054  SODCC.1; superoxide dismutase [Cu-Zn] 2 [KO:K04565] [EC:1.15.1.1]
            543981  SODCP.2; superoxide dismutase [Cu-Zn], chloroplastic [KO:K04565] [EC:1.15.1.1]
            101248277  superoxide dismutase [Fe], chloroplastic [KO:K04564] [EC:1.15.1.1]
            101256386  Mn-superoxide dismutase [KO:K04564] [EC:1.15.1.1]
            544259  FESOD; iron superoxide dismutase isoform 2 [KO:K04564] [EC:1.15.1.1]
            101256231  superoxide dismutase [Fe] 3, chloroplastic [KO:K04564] [EC:1.15.1.1]
            101252744  xanthine dehydrogenase 1-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
            101252457  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
            101264111  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
REFERENCE   PMID:17055078
  AUTHORS   Wanders RJ, Waterham HR
  TITLE     Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  JOURNAL   Biochim Biophys Acta 1763:1707-20 (2006)
            DOI:10.1016/j.bbamcr.2006.08.010
REFERENCE   PMID:17055079
  AUTHORS   Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  TITLE     Peroxisome biogenesis disorders.
  JOURNAL   Biochim Biophys Acta 1763:1733-48 (2006)
            DOI:10.1016/j.bbamcr.2006.09.010
REFERENCE   PMID:17010456
  AUTHORS   Rottensteiner H, Theodoulou FL
  TITLE     The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  JOURNAL   Biochim Biophys Acta 1763:1527-40 (2006)
            DOI:10.1016/j.bbamcr.2006.08.012
REFERENCE   PMID:16631601
  AUTHORS   Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  TITLE     Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  JOURNAL   Biochem Biophys Res Commun 344:948-54 (2006)
            DOI:10.1016/j.bbrc.2006.04.008
REL_PATHWAY sly00071  Fatty acid degradation
            sly00230  Purine metabolism
            sly00564  Glycerophospholipid metabolism
            sly00565  Ether lipid metabolism
            sly00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko04146
///
