ENTRY       sly04145                    Pathway
NAME        Phagosome - Solanum lycopersicum (tomato)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP sly04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101247988  syntaxin-81-like [KO:K08492]
            101249911  syntaxin-81 [KO:K08492]
            101249333  25.3 kDa vesicle transport protein [KO:K08517]
            101257054  25.3 kDa vesicle transport protein [KO:K08517]
            101261994  25.3 kDa vesicle transport protein [KO:K08517]
            101249373  25.3 kDa vesicle transport protein [KO:K08517]
            101261973  ras-related protein RHN1 isoform X1 [KO:K07889]
            101265393  ras-related protein RHN1 [KO:K07889]
            101245117  ras-related protein RABF1 [KO:K07889]
            101250591  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            543861  vacuolar H+-ATPase A1 subunit isoform [KO:K02145] [EC:7.1.2.2]
            543862  vacuolar H+-ATPase A2 subunit isoform [KO:K02145] [EC:7.1.2.2]
            101244132  V-type proton ATPase subunit B2 [KO:K02147]
            101245703  V-type proton ATPase subunit B 2 [KO:K02147]
            101251661  V-type proton ATPase subunit C [KO:K02148]
            101246756  V-type proton ATPase subunit D [KO:K02149]
            101244849  V-type proton ATPase subunit E [KO:K02150]
            543663  V-type proton ATPase subunit E [KO:K02150]
            101264666  V-type proton ATPase subunit E-like [KO:K02150]
            101265947  V-type proton ATPase subunit E [KO:K02150]
            101264086  V-type proton ATPase subunit F [KO:K02151]
            101258944  V-type proton ATPase subunit G 1 [KO:K02152]
            101247101  V-type proton ATPase subunit G 1-like [KO:K02152]
            101254490  V-type proton ATPase subunit G 2 [KO:K02152]
            101256222  V-type proton ATPase subunit e1-like [KO:K02153]
            101253466  V-type proton ATPase subunit e1 [KO:K02153]
            778317  V-type proton ATPase subunit e-like precursor [KO:K02153]
            101265176  V-type proton ATPase subunit a3 [KO:K02154]
            101258760  V-type proton ATPase subunit a1-like [KO:K02154]
            101245671  V-type proton ATPase subunit a2-like [KO:K02154]
            101251546  V-type proton ATPase subunit a1 [KO:K02154]
            101264386  V-type proton ATPase subunit d2 [KO:K02146]
            101264594  V-type proton ATPase subunit H isoform X1 [KO:K02144]
            101250816  V-type proton ATPase subunit H [KO:K02144]
            101252945  V-type proton ATPase subunit c2 [KO:K02155]
            101253279  V-type proton ATPase subunit c2 [KO:K02155]
            101253944  V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
            101254245  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            543525  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            101268694  V-type proton ATPase subunit c''1 [KO:K03661]
            101246164  V-type proton ATPase subunit c''1 [KO:K03661]
            101263553  ras-related protein RABG3f [KO:K07897]
            101261599  ras-related protein Rab7 [KO:K07897]
            101257955  ras-related protein Rab7 [KO:K07897]
            101258647  ras-related protein Rab7-like [KO:K07897]
            101244864  tubulin alpha chain [KO:K07374]
            101255154  tubulin alpha chain-like [KO:K07374]
            101248155  tubulin alpha-3 chain-like [KO:K07374]
            101253365  tubulin alpha-2 chain-like [KO:K07374]
            101254013  tubulin alpha-3 chain [KO:K07374]
            101251552  tubulin beta-1 chain [KO:K07375]
            101246411  tubulin beta chain-like [KO:K07375]
            101253952  tubulin beta-2 chain [KO:K07375]
            101248630  tubulin beta-5 chain [KO:K07375]
            101252240  tubulin beta-2 chain [KO:K07375]
            101248956  tubulin beta chain-like [KO:K07375]
            778227  TUB; beta-tubulin [KO:K07375]
            101265829  tubulin beta-1 chain [KO:K07375]
            101262728  tubulin beta chain [KO:K07375]
            101262621  tubulin beta-8 chain [KO:K07375]
            101246905  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X2 [KO:K00921] [EC:2.7.1.150]
            101263796  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]
            101259601  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
            101260812  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            101255884  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            101252196  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
            101260244  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            101245021  protein transport protein Sec61 subunit alpha [KO:K10956]
            101259292  protein transport protein Sec61 subunit alpha [KO:K10956]
            101263722  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
            101245632  protein transport protein Sec61 subunit beta [KO:K09481]
            101268397  protein transport protein Sec61 subunit beta [KO:K09481]
            101268107  protein transport protein Sec61 subunit beta-like [KO:K09481]
            101245464  protein transport protein Sec61 subunit beta-like [KO:K09481]
            101247903  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
            101243898  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
            101246093  calreticulin [KO:K08057]
            101248677  calreticulin-3 [KO:K08057]
            101262304  calreticulin-3-like [KO:K08057]
            778323  CNX61.0; calnexin-like protein precursor [KO:K08054]
            101247033  calnexin homolog 1-like isoform X1 [KO:K08054]
            101265779  rac-like GTP-binding protein 5 [KO:K04392]
            101254357  rac-like GTP-binding protein ARAC1 [KO:K04392]
            101251031  rac-like GTP-binding protein 5 [KO:K04392]
            101244338  rac-like GTP-binding protein RAC13 [KO:K04392]
            101244348  rac-like GTP-binding protein RHO1 [KO:K04392]
            101252165  rac-like GTP-binding protein 3 isoform X1 [KO:K04392]
            101253160  rac-like GTP-binding protein ARAC7 isoform X1 [KO:K04392]
            104645763  ROP GTPases family protein [KO:K04392]
            101250317  rac-like GTP-binding protein ARAC7 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY sly04144  Endocytosis
KO_PATHWAY  ko04145
///
