ENTRY       sly04136                    Pathway
NAME        Autophagy - other - Solanum lycopersicum (tomato)
DESCRIPTION Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP sly04136  Autophagy - other
DBLINKS     GO: 0006914
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101246173  regulatory-associated protein of TOR 1 [KO:K07204]
            101266988  regulatory-associated protein of TOR 2 [KO:K07204]
            101259295  serine/threonine-protein kinase TOR isoform X2 [KO:K07203] [EC:2.7.11.1]
            101258340  protein LST8 homolog [KO:K08266]
            101247744  serine/threonine-protein kinase ATG1c isoform X1 [KO:K08269] [EC:2.7.11.1]
            101244264  autophagy-related protein 13 [KO:K08331]
            101259849  autophagy-related protein 13a-like [KO:K08331]
            101253244  autophagy-related protein 101 isoform X1 [KO:K19730]
            101263274  autophagy-related protein 101 [KO:K19730]
            101251393  autophagy-related protein 11 isoform X1 [KO:K08330]
            101267441  PP2A regulatory subunit TAP46 [KO:K17606]
            101257003  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
            101245881  serine/threonine-protein phosphatase PP2A-5 catalytic subunit [KO:K04382] [EC:3.1.3.16]
            101252803  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
            544183  PP2Ac1; protein phosphatase 2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
            544262  PP2Ac2; protein phosphatase 2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
            101254295  autophagy-related protein 9 [KO:K17907]
            101260283  autophagy-related protein 2 isoform X1 [KO:K17906]
            101255009  autophagy-related protein 18b isoform X2 [KO:K17908]
            778283  atg6; beclin 1 protein [KO:K08334]
            101250591  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            101248472  serine/threonine-protein kinase VPS15 isoform X1 [KO:K08333] [EC:2.7.11.1]
            101259616  ubiquitin-like protein ATG12 [KO:K08336]
            101261376  autophagy protein 5 [KO:K08339]
            101253273  autophagy-related protein 16 [KO:K17890]
            101246793  ubiquitin-like modifier-activating enzyme atg7 [KO:K08337]
            101262344  ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
            101249556  autophagy-related protein 3 [KO:K08343]
            101251945  autophagy-related protein 8C [KO:K08341]
            101253062  autophagy-related protein 8C isoform X1 [KO:K08341]
            101246095  autophagy-related protein 8C [KO:K08341]
            100736468  ATG8a; autophagy-related protein 8a [KO:K08341]
            100736469  autophagy 8f [KO:K08341]
            100736470  autophagy 8h [KO:K08341]
            101265259  autophagy-related protein 8f isoform X1 [KO:K08341]
            101249673  cysteine protease ATG4 isoform X2 [KO:K08342] [EC:3.4.22.-]
COMPOUND    C00350  Phosphatidylethanolamine
            C01194  1-Phosphatidyl-D-myo-inositol
            C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:20962583
  AUTHORS   Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  TITLE     Autophagy in protists.
  JOURNAL   Autophagy 7:127-58 (2011)
            DOI:10.4161/auto.7.2.13310
REFERENCE   PMID:21660427
  AUTHORS   Avin-Wittenberg T, Honig A, Galili G
  TITLE     Variations on a theme: plant autophagy in comparison to yeast and mammals.
  JOURNAL   Protoplasma 249:285-99 (2012)
            DOI:10.1007/s00709-011-0296-z
REFERENCE   PMID:22242963
  AUTHORS   Liu Y, Bassham DC
  TITLE     Autophagy: pathways for self-eating in plant cells.
  JOURNAL   Annu Rev Plant Biol 63:215-37 (2012)
            DOI:10.1146/annurev-arplant-042811-105441
REFERENCE   PMID:22764279
  AUTHORS   Yoshimoto K
  TITLE     Beginning to understand autophagy, an intracellular self-degradation system in plants.
  JOURNAL   Plant Cell Physiol 53:1355-65 (2012)
            DOI:10.1093/pcp/pcs099
REFERENCE   PMID:24563201
  AUTHORS   Li F, Chung T, Vierstra RD
  TITLE     AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  JOURNAL   Plant Cell 26:788-807 (2014)
            DOI:10.1105/tpc.113.120014
REFERENCE   PMID:26598298
  AUTHORS   Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  TITLE     Autophagy in Plants--What's New on the Menu?
  JOURNAL   Trends Plant Sci 21:134-44 (2016)
            DOI:10.1016/j.tplants.2015.10.008
REFERENCE   PMID:26614870
  AUTHORS   Yang X, Bassham DC
  TITLE     New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  JOURNAL   Int Rev Cell Mol Biol 320:1-40 (2015)
            DOI:10.1016/bs.ircmb.2015.07.005
KO_PATHWAY  ko04136
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