ENTRY       sly04120                    Pathway
NAME        Ubiquitin mediated proteolysis - Solanum lycopersicum (tomato)
DESCRIPTION Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP sly04120  Ubiquitin mediated proteolysis
DBLINKS     GO: 0016567
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101267758  ubq1-1; ubiquitin [KO:K08770]
            101262050  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            101244464  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            101245540  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
            101264240  ubiquitin-ribosomal fusion protein [KO:K02927]
            101247925  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
            101265661  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            101256912  ubi3; ubiquitin-40S ribosomal protein S27a [KO:K02977]
            101248858  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
            101248559  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
            101245462  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
            101253520  ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:6.2.1.45]
            101249529  SUMO-activating enzyme subunit 1B-1 [KO:K10684] [EC:6.2.1.45]
            543732  ubiquitin activating enzyme [KO:K10684] [EC:6.2.1.45]
            101267748  SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
            101252115  NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
            101265795  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
            101258213  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
            101247803  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
            101250809  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
            101266186  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
            101250739  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
            100303774  UBC; ubiquitin conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
            101265051  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
            101260872  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
            101264951  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
            101245577  ubiquitin-conjugating enzyme E2 -like protein [KO:K20217] [EC:2.3.2.23]
            101256619  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            101262710  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            101262418  ubiquitin-conjugating enzyme E2 7 isoform X1 [KO:K10575] [EC:2.3.2.23]
            101262721  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            101265863  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
            101254242  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
            101261295  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
            101266677  ubiquitin-conjugating enzyme E2 5-like [KO:K10576] [EC:2.3.2.23]
            101253514  ubiquitin-conjugating enzyme E2 5 [KO:K10576] [EC:2.3.2.23]
            101244048  SUMO-conjugating enzyme SCE1 [KO:K10577]
            101256169  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
            101247296  SUMO-conjugating enzyme SCE1 isoform X2 [KO:K10577]
            101248192  SUMO-conjugating enzyme SCE1 [KO:K10577]
            101260621  SUMO-conjugating enzyme SCE1-like [KO:K10577]
            101255113  SUMO-conjugating enzyme SCE1-like [KO:K10577]
            101266615  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            543683  ubiquitin conjugating enzyme 2 [KO:K04554] [EC:2.3.2.23]
            101248401  ubiquitin-conjugating enzyme E2 34 isoform X1 [KO:K04554] [EC:2.3.2.23]
            543810  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
            101243776  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
            101249877  ubiquitin-conjugating enzyme family protein [KO:K10579] [EC:2.3.2.34]
            101261716  NEDD8-conjugating enzyme Ubc12-like isoform X1 [KO:K10579] [EC:2.3.2.34]
            104645363  uncharacterized protein LOC104645363 [KO:K10579] [EC:2.3.2.34]
            101266538  Fni3; ubiquitin-conjugating enzyme E2 35-like [KO:K10580] [EC:2.3.2.23]
            101262054  Ubc13-2; ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
            101250073  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
            101244501  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
            101261893  uncharacterized protein LOC101261893 isoform X1 [KO:K10581] [EC:2.3.2.24]
            101267744  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
            101243938  probable ubiquitin-conjugating enzyme E2 23 isoform X1 [KO:K10581] [EC:2.3.2.24]
            101254146  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
            101245015  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.25]
            101243704  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.25]
            544292  UBC27; ubiquitin conjugating enzyme [KO:K04649] [EC:2.3.2.23]
            101250834  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
            101246856  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
            101264868  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            101257890  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
            101247472  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            101267369  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            101254909  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            101261768  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
            101263464  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
            101263446  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
            101253831  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
            101260503  E3 ubiquitin-protein ligase DIS1 isoform X1 [KO:K04506] [EC:2.3.2.27]
            101257844  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
            101262896  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
            101256260  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
            101262084  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
            109119263  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
            101246723  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
            101265083  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
            101264159  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
            101258961  SINA4; E3 ubiquitin ligase SINA4 [KO:K04506] [EC:2.3.2.27]
            101256849  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
            101249698  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
            101259391  WD repeat-containing protein RUP2 [KO:K10143] [EC:2.3.2.27]
            543547  COP1; putative E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
            101246466  E3 ubiquitin-protein ligase MIEL1 isoform X2 [KO:K10144] [EC:2.3.2.27]
            101256801  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            101247534  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
            101266831  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
            101254223  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            101255315  E4 SUMO-protein ligase PIAL2 isoform X1 [KO:K04706] [EC:2.3.2.-]
            101257051  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
            101262220  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X1 [KO:K10601] [EC:2.3.2.27]
            101265515  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
            101249890  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            101259644  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
            101249757  cullin-1 [KO:K03347]
            101255260  SSK2; SKP1-like protein 11-like [KO:K03094]
            101255553  SSK3; SKP1-like protein 11-like [KO:K03094]
            101268040  SKP1-like protein 1A [KO:K03094]
            101256470  SKP1-like protein 1B [KO:K03094]
            101246871  SKP1-like protein 1B [KO:K03094]
            101246572  SKP1-like protein 1B [KO:K03094]
            101264381  SKP1-like protein 11 [KO:K03094]
            101244826  SKP1-like protein 11 [KO:K03094]
            101246287  SKP1-like protein 1B [KO:K03094]
            101243954  SKP1-like protein 1A [KO:K03094]
            101256150  SKP1-like protein 1 [KO:K03094]
            101268328  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
            101250894  SKP1-like protein 1B [KO:K03094]
            101251188  SKP1-like protein 11 [KO:K03094]
            101254991  F-box protein SKP2B [KO:K03875]
            101267899  elongin-C [KO:K03872]
            101253687  uncharacterized protein LOC101253687 [KO:K03873]
            101248999  cullin-3A [KO:K03869]
            101254652  cullin-3A-like [KO:K03869]
            101248739  cullin-4 [KO:K10609]
            544135  CUL4; cullin 4 [KO:K10609]
            778355  DDB1; DNA damage-binding protein 1 [KO:K10610]
            101265575  protein DAMAGED DNA-BINDING 2 [KO:K10140]
            101255378  WD repeat-containing protein ATCSA-1-like [KO:K10570]
            778329  Det1; light-mediated development protein DET1 [KO:K10571]
            101266269  anaphase-promoting complex subunit 11 [KO:K03358]
            101243993  anaphase-promoting complex subunit 2 [KO:K03349]
            101251072  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
            101250197  cdc20-1; cell division control 20-1 [KO:K03363]
            101261334  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
            101244602  cell division cycle 20.2, cofactor of APC complex isoform X1 [KO:K03363]
            101257937  protein FIZZY-RELATED 2-like [KO:K03364]
            101250720  ccs52A; protein FIZZY-RELATED 2 [KO:K03364]
            101260349  ccs52B; cell cycle switch 52B [KO:K03364]
            101245767  anaphase-promoting complex subunit 1 [KO:K03348]
            101260701  cell division cycle protein 27 homolog B [KO:K03350]
            101255653  anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
            101253813  anaphase-promoting complex subunit 5 [KO:K03352]
            101261990  anaphase-promoting complex subunit 6 isoform X1 [KO:K03353]
            101244411  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
            101260121  anaphase-promoting complex subunit 8 [KO:K03355]
            101267195  anaphase-promoting complex subunit 10 [KO:K03357]
REFERENCE   PMID:16922370
  AUTHORS   Kamura T.
  TITLE     [Cullin-based E3 family]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
REFERENCE   PMID:16922408
  AUTHORS   Matsuda N.
  TITLE     [Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
REFERENCE   PMID:16922367
  AUTHORS   Tokunaga F.
  TITLE     [E2 ubiquitin-conjugating enzymes: structures and functions]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
REFERENCE   PMID:16816840
  AUTHORS   Nalepa G, Rolfe M, Harper JW.
  TITLE     Drug discovery in the ubiquitin-proteasome system.
  JOURNAL   Nat Rev Drug Discov 5:596-613 (2006)
            DOI:10.1038/nrd2056
REFERENCE   PMID:16405856
  AUTHORS   Hsu YJ, Goodman SR.
  TITLE     Spectrin and ubiquitination: a review.
  JOURNAL   Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
REFERENCE   PMID:12944364
  AUTHORS   Hatakeyama S, Nakayama KI.
  TITLE     Ubiquitylation as a quality control system for intracellular proteins.
  JOURNAL   J Biochem 134:1-8 (2003)
            DOI:10.1093/jb/mvg106
REFERENCE   PMID:17588513
  AUTHORS   Lee J, Zhou P.
  TITLE     DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  JOURNAL   Mol Cell 26:775-80 (2007)
            DOI:10.1016/j.molcel.2007.06.001
REL_PATHWAY sly03050  Proteasome
KO_PATHWAY  ko04120
///
