ENTRY       sly04016                    Pathway
NAME        MAPK signaling pathway - plant - Solanum lycopersicum (tomato)
DESCRIPTION Mitogen-activated protein kinase (MAPK) cascades, the evolutionarily conserved signaling modules in all eukaryotes, serve in transducing extracellular signals to the nucleus or cytoplasm for appropriate cellular responses, including cell division, differentiation, programmed cell death, and adaption to various stresses. In plant, several cascades are triggered by different biotic and abiotic stress stimuli such as pathogen infection, wounding, low temperature, drought, osmotic shock, high salinity, and reactive oxygen species. MAPK pathways also play pivotal roles in processes such as hormonal and developmental signaling. Multiple functional pathways initiated from distinct receptors often share the same kinase components while maintaining their signaling specificity. In contrast to those of animals and fungi, all the plant MAPK genes that have been reported belong to extracellular signal-regulated kinase (ERK) subfamily.
CLASS       Environmental Information Processing; Signal transduction
PATHWAY_MAP sly04016  MAPK signaling pathway - plant
DBLINKS     GO: 0000165
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101259509  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:2.7.11.1]
            101263667  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:2.7.11.1]
            101248077  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            101248361  LRR receptor-like serine/threonine-protein kinase EFR [KO:K13420] [EC:2.7.11.1]
            101266623  receptor kinase-like protein Xa21 [KO:K13420] [EC:2.7.11.1]
            101246110  LRR receptor-like serine/threonine-protein kinase EFR [KO:K13420] [EC:2.7.11.1]
            101264408  putative receptor-like protein kinase At3g47110 [KO:K13420] [EC:2.7.11.1]
            104645856  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            104645860  LRR receptor-like serine/threonine-protein kinase GSO1 isoform X1 [KO:K13420] [EC:2.7.11.1]
            104645862  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            101247789  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            100736531  SERK3B; somatic embryogenesis receptor kinase 3B precursor [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            100736467  SERK3A; somatic embryogenesis receptor kinase 3A precursor [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            101264342  mitogen-activated protein kinase kinase kinase 1-like [KO:K13414] [EC:2.7.11.25]
            543720  mek1; MAP kinase kinase [KO:K20603] [EC:2.7.12.2]
            100736536  MAPK7; mitogen-activated protein kinase 7 [KO:K20600] [EC:2.7.11.24]
            100736474  MAPK6; mitogen-activated protein kinase 6 [KO:K20600] [EC:2.7.11.24]
            100534642  MAPK5; mitogen-activated protein kinase 5 [KO:K20600] [EC:2.7.11.24]
            104647127  protein MKS1 [KO:K20725]
            101244245  protein MKS1 [KO:K20725]
            101249467  protein MKS1-like [KO:K20725]
            101268787  probable WRKY transcription factor 26 [KO:K13424]
            101255501  WRKY31; WRKY transcription factor 31 [KO:K13424]
            543946  MKK2; mitogen-activated protein kinase kinase 2 [KO:K13413] [EC:2.7.12.2]
            543880  MPK3; mitogen-activated protein kinase 3 [KO:K20536] [EC:2.7.11.24]
            543792  mpka1;1; Mitogen-activated protein kinase [KO:K14512] [EC:2.7.11.24]
            543879  MPK2; mitogen-activated protein kinase 2 [KO:K14512] [EC:2.7.11.24]
            101257481  transcription factor VIP1 [KO:K20557]
            101263700  transcription factor VIP1 [KO:K20557]
            544083  PR-1a1; pathogenesis-related protein 1A1 precursor [KO:K13449]
            544123  PR1b1; pathogenesis-related leaf protein 6 precursor [KO:K13449]
            544185  P4; pathogenesis-related leaf protein 4 precursor [KO:K13449]
            101257309  pathogenesis-related leaf protein 4-like [KO:K13449]
            101265854  pathogenesis-related leaf protein 4 [KO:K13449]
            100191111  PR1 protein precursor [KO:K13449]
            101257608  pathogenesis-related leaf protein 6 [KO:K13449]
            101266151  PR1a2; pathogenesis-related protein precursor [KO:K13449]
            101254769  WRKY transcription factor 22-like [KO:K13425]
            104646114  probable WRKY transcription factor 27 [KO:K13425]
            104647603  probable WRKY transcription factor 15 [KO:K13425]
            104647604  probable WRKY transcription factor 27 [KO:K13425]
            104647595  probable WRKY transcription factor 4 [KO:K13425]
            101258194  WRKY transcription factor 22-like [KO:K13425]
            112941466  disease resistance protein RRS1-like [KO:K13425]
            101261749  WRKY transcription factor 22 [KO:K13425]
            104647605  probable WRKY transcription factor 27 [KO:K13425]
            101245784  probable WRKY transcription factor 29 [KO:K13426]
            101258054  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
            101258353  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
            606304  ACS2; 1-aminocyclopropane-1-carboxylate synthase 2 [KO:K20772] [EC:4.4.1.14]
            101246650  LE-ACS1B; 1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
            606302  ACS6; 1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
            544028  ACS1A; 1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
            101260914  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
            101262346  serine/threonine-protein kinase OXI1 [KO:K20714] [EC:2.7.11.1]
            101244761  nucleoside diphosphate kinase 2, chloroplastic [KO:K00940] [EC:2.7.4.6]
            544095  NDK; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
            101262221  nucleoside diphosphate kinase 2, chloroplastic [KO:K00940] [EC:2.7.4.6]
            104648939  nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
            101260252  nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
            101264683  mitogen-activated protein kinase kinase kinase NPK1 [KO:K20606] [EC:2.7.11.25]
            101252056  mitogen-activated protein kinase kinase 3 [KO:K20607] [EC:2.7.12.2]
            100736512  MPK9; mitogen-activated protein kinase 9 [KO:K20535] [EC:2.7.11.24]
            100736510  MAPK8; mitogen-activated protein kinase 8 [KO:K20537] [EC:2.7.11.24]
            543834  ETR6; ethylene receptor ETR6 precursor [KO:K14509] [EC:2.7.13.-]
            101249081  protein EIN4-like [KO:K14509] [EC:2.7.13.-]
            544279  NR; ethylene receptor NR [KO:K14509] [EC:2.7.13.-]
            543588  ETR4; ethylene receptor ETR4 precursor [KO:K14509] [EC:2.7.13.-]
            543589  ETR5; ethylene receptor ETR5 precursor [KO:K14509] [EC:2.7.13.-]
            606298  ETR1; ethylene receptor 1 [KO:K14509] [EC:2.7.13.-]
            606299  ETR2; ethylene receptor 2 [KO:K14509] [EC:2.7.13.-]
            544127  CTR1; ethylene-inducible CTR1-like protein kinase [KO:K14510] [EC:2.7.11.1]
            543907  CTR3; CTR1-like protein kinase [KO:K14510] [EC:2.7.11.1]
            543908  CTR4; CTR1-like protein kinase [KO:K14510] [EC:2.7.11.1]
            778262  green ripe [KO:K20726]
            778265  green ripe-like 2 [KO:K20726]
            778264  green ripe-like 1 [KO:K20726]
            101263483  copper-transporting ATPase RAN1 [KO:K17686] [EC:7.2.2.8]
            101255059  copper-transporting ATPase HMA4-like [KO:K17686] [EC:7.2.2.8]
            101261734  probable copper-transporting ATPase HMA5 isoform X1 [KO:K17686] [EC:7.2.2.8]
            101262035  LOW QUALITY PROTEIN: probable copper-transporting ATPase HMA5 [KO:K17686] [EC:7.2.2.8]
            101267332  copper-transporting ATPase PAA2, chloroplastic [KO:K17686] [EC:7.2.2.8]
            101265776  copper-transporting ATPase PAA1, chloroplastic isoform X1 [KO:K17686] [EC:7.2.2.8]
            543948  MKK4; MAPKK [KO:K20604] [EC:2.7.12.2]
            101264242  ETHYLENE INSENSITIVE 3-like 3 protein isoform X1 [KO:K14514]
            101253880  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
            101249950  ETHYLENE INSENSITIVE 3-like 3 protein isoform X1 [KO:K14514]
            101260322  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
            101255685  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
            543680  EIL3; protein EIN3-like3 [KO:K14514]
            544228  EIL2; protein EIN3-like2 [KO:K14514]
            543518  EIL4; protein ETHYLENE-INSENSITIVE 3-like 4 [KO:K14514]
            543679  EIL1; protein ETHYLENE INSENSITIVE 3-Like 1 [KO:K14514]
            543928  EIN2; ethylene-insensitive protein 2 [KO:K14513]
            778234  EBF1; EIN3-binding F-box protein 1 [KO:K14515]
            778235  EBF2; EIN3-binding F-box protein 2 [KO:K14515]
            101248690  EIN3-binding F-box protein 1 [KO:K14515]
            101253906  EIN3-binding F-box protein 1-like [KO:K14515]
            100147714  XRN4; protein ETHYLENE-INSENSITIVE5 [KO:K20553] [EC:3.1.13.-]
            543712  EREB; ethylene responsive element binding protein [KO:K14516]
            606712  ethylene-responsive transcription factor 1 [KO:K14516]
            101267105  ethylene-responsive transcription factor 1B [KO:K14516]
            101247461  ethylene-responsive transcription factor 1B [KO:K14516]
            101262522  ethylene-responsive transcription factor 1B-like [KO:K14516]
            101265792  ethylene-responsive transcription factor 1B-like [KO:K14516]
            101244256  ethylene-responsive transcription factor 1B-like [KO:K14516]
            101245906  ethylene-responsive transcription factor 1B-like [KO:K14516]
            101246590  ethylene-responsive transcription factor 1B [KO:K14516]
            101265876  endochitinase A-like [KO:K20547] [EC:3.2.1.14]
            101258911  endochitinase A-like [KO:K20547] [EC:3.2.1.14]
            101267358  endochitinase 4 [KO:K20547] [EC:3.2.1.14]
            544147  CHI17; acidic 27 kDa endochitinase precursor [KO:K20547] [EC:3.2.1.14]
            544149  CHI3; acidic 26 kDa endochitinase precursor [KO:K20547] [EC:3.2.1.14]
            544148  CHI9; basic 30 kDa endochitinase precursor [KO:K20547] [EC:3.2.1.14]
            101259497  endochitinase-like [KO:K20547] [EC:3.2.1.14]
            101251136  endochitinase [KO:K20547] [EC:3.2.1.14]
            101266770  endochitinase 3-like [KO:K20547] [EC:3.2.1.14]
            544146  CHI14; basic endochitinase precursor [KO:K20547] [EC:3.2.1.14]
            544165  MYC2; transcription factor MYC2 [KO:K13422]
            101261048  MYC1; transcription factor MYC1 [KO:K13422]
            101251256  abscisic acid receptor PYL8 [KO:K14496]
            101256856  abscisic acid receptor PYL4 [KO:K14496]
            101261414  abscisic acid receptor PYL4-like [KO:K14496]
            101245998  abscisic acid receptor PYL4-like [KO:K14496]
            101250944  abscisic acid receptor PYL4 [KO:K14496]
            101246907  abscisic acid receptor PYL2-like [KO:K14496]
            101246807  abscisic acid receptor PYL9 [KO:K14496]
            101245105  regulatory component of ABA receptor3-like [KO:K14496]
            101258963  abscisic acid receptor PYL4 [KO:K14496]
            101267127  abscisic acid receptor PYR1 [KO:K14496]
            101268417  abscisic acid receptor PYR1 [KO:K14496]
            101258886  abscisic acid receptor PYL3 [KO:K14496]
            101263741  abscisic acid receptor PYL4-like [KO:K14496]
            101253664  probable protein phosphatase 2C 75 [KO:K14497] [EC:3.1.3.16]
            101253974  probable protein phosphatase 2C 75 [KO:K14497] [EC:3.1.3.16]
            101254275  probable protein phosphatase 2C 75 [KO:K14497] [EC:3.1.3.16]
            101249794  protein phosphatase 2C 51-like [KO:K14497] [EC:3.1.3.16]
            100316894  PP2C-1; protein phosphatase 2C ABI2 homolog [KO:K14497] [EC:3.1.3.16]
            101248778  protein phosphatase 2C 37 [KO:K14497] [EC:3.1.3.16]
            101268450  probable protein phosphatase 2C 75 isoform X2 [KO:K14497] [EC:3.1.3.16]
            101265524  protein phosphatase 2C 53 isoform X1 [KO:K14497] [EC:3.1.3.16]
            100316895  PP2C-2; protein phosphatase 2C AHG3 homolog [KO:K14497] [EC:3.1.3.16]
            101258071  protein phosphatase 2C [KO:K14497] [EC:3.1.3.16]
            101244003  probable protein phosphatase 2C 24 [KO:K14497] [EC:3.1.3.16]
            101261835  protein phosphatase 2C 50 isoform X2 [KO:K14497] [EC:3.1.3.16]
            101255229  protein phosphatase 2C 51-like [KO:K14497] [EC:3.1.3.16]
            101250718  probable protein phosphatase 2C 6 [KO:K14497] [EC:3.1.3.16]
            101268620  serine/threonine-protein kinase SRK2E [KO:K14498] [EC:2.7.11.1]
            101248921  serine/threonine-protein kinase SRK2B [KO:K14498] [EC:2.7.11.1]
            101251432  serine/threonine-protein kinase SRK2I isoform X1 [KO:K14498] [EC:2.7.11.1]
            101262107  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
            101261086  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
            100037510  SRK2C; SNF1-related kinase [KO:K14498] [EC:2.7.11.1]
            101250433  serine/threonine-protein kinase SAPK3 [KO:K14498] [EC:2.7.11.1]
            101265336  serine/threonine-protein kinase SAPK7 [KO:K14498] [EC:2.7.11.1]
            101265257  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101261859  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101255811  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101256105  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101258387  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101254919  mitogen-activated protein kinase kinase kinase 17-like [KO:K20716]
            101255217  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101254612  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
            101259333  catalase isozyme 3 [KO:K03781] [EC:1.11.1.6]
            543990  cat1; catalase isozyme 1 [KO:K03781] [EC:1.11.1.6]
            543585  CAT2; catalase isozyme 2 [KO:K03781] [EC:1.11.1.6]
            101245298  calmodulin [KO:K02183]
            101251639  probable calcium-binding protein CML30 [KO:K02183]
            543984  CaM6; calmodulin [KO:K02183]
            101243958  calmodulin [KO:K02183]
            544131  CaM2; calmodulin 2 [KO:K02183]
            101256315  CaM1; calmodulin 1 [KO:K02183]
            101256434  CaM3; calmodulin 3 [KO:K02183]
            101249621  CaM5; calmodulin 5 [KO:K02183]
            101258272  probable calcium-binding protein CML30 [KO:K02183]
            101264550  calcium-binding protein CP1 [KO:K02183]
            101251928  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            101252395  respiratory burst oxidase homolog protein E-like isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            101246440  respiratory burst oxidase homolog protein D [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            101258675  respiratory burst oxidase homolog protein E isoform X2 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            543571  RBOH1; NADPH oxidase isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            543603  Wfi1; whitefly-induced gp91-phox [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            101266023  protein EPIDERMAL PATTERNING FACTOR 2 [KO:K20729]
            104644846  protein EPIDERMAL PATTERNING FACTOR 1 [KO:K20729]
            104647140  transcription termination factor MTERF5, chloroplastic-like [KO:K20729]
            101244640  LRR receptor-like serine/threonine-protein kinase ERL1 [KO:K20718] [EC:2.7.11.1]
            101266437  LRR receptor-like serine/threonine-protein kinase ERECTA [KO:K20718] [EC:2.7.11.1]
            101258826  mitogen-activated protein kinase kinase kinase YODA-like [KO:K20717] [EC:2.7.11.25]
            101263615  mitogen-activated protein kinase kinase kinase YODA [KO:K20717] [EC:2.7.11.25]
            101255020  mitogen-activated protein kinase kinase kinase YODA isoform X1 [KO:K20717] [EC:2.7.11.25]
            101256653  transcription factor SPEECHLESS [KO:K20558]
REFERENCE   PMID:11875555
  AUTHORS   Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
  TITLE     MAP kinase signalling cascade in Arabidopsis innate immunity.
  JOURNAL   Nature 415:977-83 (2002)
            DOI:10.1038/415977a
REFERENCE   PMID:12119167
  AUTHORS   
  TITLE     Mitogen-activated protein kinase cascades in plants: a new nomenclature.
  JOURNAL   Trends Plant Sci 7:301-8 (2002)
            DOI:10.1016/S1360-1385(02)02302-6
REFERENCE   PMID:18570633
  AUTHORS   Colcombet J, Hirt H
  TITLE     Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes.
  JOURNAL   Biochem J 413:217-26 (2008)
            DOI:10.1042/BJ20080625
REFERENCE   PMID:18692429
  AUTHORS   Kendrick MD, Chang C
  TITLE     Ethylene signaling: new levels of complexity and regulation.
  JOURNAL   Curr Opin Plant Biol 11:479-85 (2008)
            DOI:10.1016/j.pbi.2008.06.011
REFERENCE   PMID:20441529
  AUTHORS   Rodriguez MC, Petersen M, Mundy J
  TITLE     Mitogen-activated protein kinase signaling in plants.
  JOURNAL   Annu Rev Plant Biol 61:621-49 (2010)
            DOI:10.1146/annurev-arplant-042809-112252
REFERENCE   PMID:20980831
  AUTHORS   Taj G, Agarwal P, Grant M, Kumar A
  TITLE     MAPK machinery in plants: recognition and response to different stresses through multiple signal transduction pathways.
  JOURNAL   Plant Signal Behav 5:1370-8 (2010)
            DOI:10.4161/psb.5.11.13020
REFERENCE   PMID:23263767
  AUTHORS   Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S
  TITLE     A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.
  JOURNAL   Plant Cell 24:4948-60 (2012)
            DOI:10.1105/tpc.112.104695
REFERENCE   PMID:25720833
  AUTHORS   Danquah A, de Zelicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J
  TITLE     Identification and characterization of an ABA-activated MAP kinase cascade in Arabidopsis thaliana.
  JOURNAL   Plant J 82:232-44 (2015)
            DOI:10.1111/tpj.12808
KO_PATHWAY  ko04016
///
