ENTRY       sly03440                    Pathway
NAME        Homologous recombination - Solanum lycopersicum (tomato)
DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP sly03440  Homologous recombination
DBLINKS     GO: 0000724
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101262086  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            101260233  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
            101261637  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
            101252794  DNA polymerase I B, chloroplastic/mitochondrial isoform X2 [KO:K02335] [EC:2.7.7.7]
            101251978  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:5.6.2.4]
            101256382  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
            101264663  double-strand break repair protein MRE11 isoform X1 [KO:K10865]
            101261187  nijmegen breakage syndrome 1 protein isoform X1 [KO:K10867]
            101253578  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
            101264126  BRCA1-associated RING domain protein 1 [KO:K10683]
            101256776  BRCA1-associated RING domain protein 1 [KO:K10683]
            101256694  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
            101255547  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
            101256914  DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
            101248303  BRCT domain-containing protein At4g02110 isoform X1 [KO:K10728]
            101267881  uncharacterized protein LOC101267881 isoform X2 [KO:K20776]
            101264320  BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
            101265551  lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
            101244820  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like isoform X1 [KO:K08775]
            101249165  protein DELETION OF SUV3 SUPPRESSOR 1(I) [KO:K10881]
            101244383  protein DELETION OF SUV3 SUPPRESSOR 1(I) [KO:K10881]
            101250913  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
            101259439  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            101255870  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            101244966  RPA32a; replication protein A [KO:K10739]
            101247082  RPA32b; replication protein A 32 kDa subunit B [KO:K10739]
            101255747  replication protein A 14 kDa subunit B-like isoform X2 [KO:K10740]
            101252714  replication protein A 14 kDa subunit B [KO:K10740]
            544003  RAD51; DNA repair protein RAD51 homolog [KO:K04482]
            101253055  DNA repair protein RAD51 homolog 2 [KO:K10869]
            101266032  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
            101264490  DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
            101255234  DNA repair protein XRCC2 homolog isoform X1 [KO:K10879]
            101245268  DNA repair protein XRCC3 homolog [KO:K10880]
            101265473  SNF2 domain-containing protein CLASSY 4-like [KO:K10875] [EC:5.6.2.-]
            104647688  uncharacterized protein LOC104647688 [KO:K10875] [EC:5.6.2.-]
            101245395  SNF2 domain-containing protein CLASSY 4-like [KO:K10875] [EC:5.6.2.-]
            101266874  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            104645619  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
            104647043  SNF2 domain-containing protein CLASSY 4-like [KO:K10875] [EC:5.6.2.-]
            101255388  protein CHROMATIN REMODELING 25 isoform X1 [KO:K10875] [EC:5.6.2.-]
            101262122  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
            101257794  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
            101252104  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
            101256637  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            101243681  DNA polymerase delta small subunit [KO:K02328]
            101258997  muscle M-line assembly protein unc-89 [KO:K03504]
            101262116  uncharacterized protein LOC101262116 [KO:K03505]
            101255630  uncharacterized protein LOC101255630 [KO:K03505]
            101260976  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
            101268032  DNA topoisomerase 3-beta isoform X1 [KO:K03165] [EC:5.6.2.1]
            101262415  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
            101256033  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
            101261911  crossover junction endonuclease EME1B isoform X1 [KO:K10882] [EC:3.1.22.-]
REFERENCE   PMID:18086882
  AUTHORS   Maloisel L, Fabre F, Gangloff S.
  TITLE     DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  JOURNAL   Mol Cell Biol 28:1373-82 (2008)
            DOI:10.1128/MCB.01651-07
REFERENCE   PMID:17571595
  AUTHORS   Haruta-Takahashi N, Iwasaki H.
  TITLE     [Recombination mediators]
  JOURNAL   Seikagaku 79:449-53 (2007)
REFERENCE   PMID:18430459
  AUTHORS   Ouyang KJ, Woo LL, Ellis NA.
  TITLE     Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  JOURNAL   Mech Ageing Dev 129:425-40 (2008)
            DOI:10.1016/j.mad.2008.03.003
REFERENCE   PMID:15902993
  AUTHORS   Kawabata M, Kawabata T, Nishibori M.
  TITLE     Role of recA/RAD51 family proteins in mammals.
  JOURNAL   Acta Med Okayama 59:1-9 (2005)
            DOI:10.18926/AMO/31987
REFERENCE   PMID:12589470
  AUTHORS   Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  TITLE     Mitotic recombination in Saccharomyces cerevisiae.
  JOURNAL   Curr Genet 42:185-98 (2003)
            DOI:10.1007/s00294-002-0346-3
REFERENCE   PMID:16935872
  AUTHORS   Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  TITLE     Rad54: the Swiss Army knife of homologous recombination?
  JOURNAL   Nucleic Acids Res 34:4115-25 (2006)
            DOI:10.1093/nar/gkl481
REFERENCE   PMID:17395553
  AUTHORS   Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  TITLE     Recombination proteins and rescue of arrested replication forks.
  JOURNAL   DNA Repair (Amst) 6:967-80 (2007)
            DOI:10.1016/j.dnarep.2007.02.016
KO_PATHWAY  ko03440
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