ENTRY       sly03430                    Pathway
NAME        Mismatch repair - Solanum lycopersicum (tomato)
DESCRIPTION DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
            The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP sly03430  Mismatch repair
DBLINKS     GO: 0006298
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101246010  uncharacterized protein LOC101246010 [KO:K07456]
            101262086  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            101258001  DNA mismatch repair protein PMS1 [KO:K10858]
            100125910  MLH1; MLH1 protein [KO:K08734]
            112941390  DNA mismatch repair protein MSH6 [KO:K08737]
            100462656  DNA mismatch repair protein MSH7 [KO:K08737]
            100462655  MSH2; mismatch repair protein [KO:K08735]
            101248748  DNA mismatch repair protein MSH3 isoform X1 [KO:K08736]
            101258812  DNA mismatch repair protein MLH3 isoform X1 [KO:K08739]
            101249468  replication factor C subunit 1 isoform X2 [KO:K10754]
            101268826  replication factor C subunit 2 [KO:K10755]
            101267918  replication factor C subunit 2 [KO:K10755]
            101253010  replication factor C subunit 3 [KO:K10756]
            101250629  replication factor C subunit 3-like isoform X2 [KO:K10756]
            101259119  uncharacterized protein LOC101259119 [KO:K10756]
            101264020  replication factor C subunit 3 [KO:K10756]
            544248  pcna; proliferating cell nuclear antigen [KO:K04802]
            101256253  exonuclease 1 isoform X3 [KO:K10746] [EC:3.1.-.-]
            101245831  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
            101250913  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
            101259439  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            101255870  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            101244966  RPA32a; replication protein A [KO:K10739]
            101247082  RPA32b; replication protein A 32 kDa subunit B [KO:K10739]
            101255747  replication protein A 14 kDa subunit B-like isoform X2 [KO:K10740]
            101252714  replication protein A 14 kDa subunit B [KO:K10740]
            101256637  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            101243681  DNA polymerase delta small subunit [KO:K02328]
            101258997  muscle M-line assembly protein unc-89 [KO:K03504]
            101262116  uncharacterized protein LOC101262116 [KO:K03505]
            101255630  uncharacterized protein LOC101255630 [KO:K03505]
            101262281  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
REFERENCE   PMID:16612326
  AUTHORS   Jiricny J.
  TITLE     The multifaceted mismatch-repair system.
  JOURNAL   Nat Rev Mol Cell Biol 7:335-46 (2006)
            DOI:10.1038/nrm1907
REFERENCE   PMID:18157157
  AUTHORS   Li GM.
  TITLE     Mechanisms and functions of DNA mismatch repair.
  JOURNAL   Cell Res 18:85-98 (2008)
            DOI:10.1038/cr.2007.115
REFERENCE   PMID:11920679
  AUTHORS   Marti TM, Kunz C, Fleck O.
  TITLE     DNA mismatch repair and mutation avoidance pathways.
  JOURNAL   J Cell Physiol 191:28-41 (2002)
            DOI:10.1002/jcp.10077
REFERENCE   PMID:11436301
  AUTHORS   Ikejima M, Shimada T.
  TITLE     [Molecular mechanism of mismatch repair]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO_PATHWAY  ko03430
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