ENTRY       sly03050                    Pathway
NAME        Proteasome - Solanum lycopersicum (tomato)
DESCRIPTION The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP sly03050  Proteasome
DBLINKS     GO: 0000502
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101255444  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            101244534  PCI superfamily protein [KO:K03033]
            101268879  26S proteasome non-ATPase regulatory subunit 9 isoform X2 [KO:K06693]
            101249344  26S proteasome non-ATPase regulatory subunit 12 homolog B-like [KO:K03035]
            101263403  26S proteasome non-ATPase regulatory subunit 12 homolog A [KO:K03035]
            101258750  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            101267619  26S proteasome non-ATPase regulatory subunit 6 homolog [KO:K03037]
            101267337  putative 26S proteasome subunit [KO:K03038]
            101245654  26S proteasome non-ATPase regulatory subunit 13 homolog B [KO:K03039]
            101264976  26S proteasome non-ATPase regulatory subunit 13 homolog B [KO:K03039]
            101259629  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            101249287  26S proteasome non-ATPase regulatory subunit 8 homolog A [KO:K03031]
            101249165  protein DELETION OF SUV3 SUPPRESSOR 1(I) [KO:K10881]
            101244383  protein DELETION OF SUV3 SUPPRESSOR 1(I) [KO:K10881]
            101263071  26S proteasome non-ATPase regulatory subunit 4 homolog isoform X1 [KO:K03029]
            101252199  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            101261464  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            101259750  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            101261856  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            101258384  26S proteasome regulatory subunit RPN13 [KO:K06691]
            101268371  26S proteasome regulatory subunit 7 homolog A [KO:K03061]
            101262927  26S proteasome regulatory subunit 7 homolog A [KO:K03061]
            101267617  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
            101245359  26S proteasome regulatory subunit 8 homolog A [KO:K03066]
            101245649  26S proteasome regulatory subunit 8 homolog A [KO:K03066]
            101259892  26S proteasome regulatory subunit 10B homolog A-like isoform X1 [KO:K03064]
            101268039  RPT4a; 26S proteasomal subunit RPT4a [KO:K03064]
            544089  LeMA-1; 26S proteasome regulatory subunit 6A homolog [KO:K03065]
            101246945  26S proteasome regulatory subunit 6A homolog [KO:K03065]
            101261929  26S proteasome regulatory subunit 6B homolog [KO:K03063]
            101268289  26S proteasome regulatory subunit 6B homolog [KO:K03063]
            101266536  proteasome activator subunit 4 [KO:K06699]
            101250370  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
            101245889  proteasome subunit alpha type-2-A [KO:K02726] [EC:3.4.25.1]
            101247839  proteasome subunit alpha type-2-B [KO:K02726] [EC:3.4.25.1]
            101257034  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
            544128  PAD1; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
            101247093  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
            101266742  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
            101266633  proteasome subunit alpha type-1-A [KO:K02725] [EC:3.4.25.1]
            101256141  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
            101253544  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
            101256394  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
            101251571  proteasome subunit beta type-7-A isoform X1 [KO:K02739] [EC:3.4.25.1]
            101248875  proteasome subunit beta type-7-A [KO:K02739] [EC:3.4.25.1]
            101259528  proteasome subunit beta type-3-A [KO:K02735] [EC:3.4.25.1]
            101249580  proteasome subunit beta type-2-B [KO:K02734] [EC:3.4.25.1]
            101250118  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
            101266585  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
            101251952  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
            101244518  probable proteasome inhibitor isoform 2 [KO:K06700]
            101258917  proteasome maturation factor UMP1-like [KO:K11599]
REFERENCE   PMID:16338359
  AUTHORS   Hirano Y, Murata S, Tanaka K
  TITLE     Large- and small-scale purification of mammalian 26S proteasomes.
  JOURNAL   Methods Enzymol 399:227-40 (2005)
            DOI:10.1016/S0076-6879(05)99015-0
REFERENCE   PMID:18497808
  AUTHORS   Saeki Y, Tanaka K
  TITLE     Cell biology: two hands for degradation.
  JOURNAL   Nature 453:460-1 (2008)
            DOI:10.1038/453460a
REFERENCE   PMID:16919475
  AUTHORS   Smith DM, Benaroudj N, Goldberg A
  TITLE     Proteasomes and their associated ATPases: a destructive combination.
  JOURNAL   J Struct Biol 156:72-83 (2006)
            DOI:10.1016/j.jsb.2006.04.012
REFERENCE   PMID:16181324
  AUTHORS   Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  TITLE     Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  JOURNAL   Immunol Rev 207:19-30 (2005)
            DOI:10.1111/j.0105-2896.2005.00308.x
REFERENCE   PMID:19483713
  AUTHORS   Darwin KH
  TITLE     Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
  JOURNAL   Nat Rev Microbiol 7:485-91 (2009)
            DOI:10.1038/nrmicro2148
REFERENCE   PMID:23495936
  AUTHORS   Tomko RJ Jr, Hochstrasser M
  TITLE     Molecular architecture and assembly of the eukaryotic proteasome.
  JOURNAL   Annu Rev Biochem 82:415-45 (2013)
            DOI:10.1146/annurev-biochem-060410-150257
REFERENCE   PMID:28583440
  AUTHORS   Budenholzer L, Cheng CL, Li Y, Hochstrasser M
  TITLE     Proteasome Structure and Assembly.
  JOURNAL   J Mol Biol 429:3500-3524 (2017)
            DOI:10.1016/j.jmb.2017.05.027
REFERENCE   PMID:29071527
  AUTHORS   Cloos J, Roeten MS, Franke NE, van Meerloo J, Zweegman S, Kaspers GJ, Jansen G
  TITLE     (Immuno)proteasomes as therapeutic target in acute leukemia.
  JOURNAL   Cancer Metastasis Rev 36:599-615 (2017)
            DOI:10.1007/s10555-017-9699-4
REFERENCE   PMID:22215586
  AUTHORS   Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  TITLE     Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
  JOURNAL   Proc Natl Acad Sci U S A 109:1479-84 (2012)
            DOI:10.1073/pnas.1119394109
REL_PATHWAY sly04120  Ubiquitin mediated proteolysis
KO_PATHWAY  ko03050
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