ENTRY       sly03013                    Pathway
NAME        Nucleocytoplasmic transport - Solanum lycopersicum (tomato)
DESCRIPTION The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP sly03013  Nucleocytoplasmic transport
DBLINKS     GO: 0050658
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101256791  aladin [KO:K14320]
            101255767  zinc finger CCCH domain-containing protein 16 [KO:K14321]
            101248103  protein GLE1 isoform X1 [KO:K18723]
            101252541  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            101243705  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            101247869  protein RAE1 [KO:K14298]
            101245750  nuclear pore complex protein NUP98A isoform X1 [KO:K14297]
            101266481  nuclear pore complex protein NUP98B-like isoform X2 [KO:K14297]
            101266921  nuclear pore complex protein NUP96 [KO:K14297]
            101268441  nuclear pore complex protein NUP214 [KO:K14317]
            101254353  nuclear pore complex protein NUP88-like [KO:K14318]
            101248262  nuclear pore complex protein NUP88 [KO:K14318]
            101248044  RAN GTPase-activating protein 2 [KO:K14319]
            101256036  RAN GTPase-activating protein 1 [KO:K14319]
            101244048  SUMO-conjugating enzyme SCE1 [KO:K10577]
            101256169  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
            101247296  SUMO-conjugating enzyme SCE1 isoform X2 [KO:K10577]
            101248192  SUMO-conjugating enzyme SCE1 [KO:K10577]
            101260621  SUMO-conjugating enzyme SCE1-like [KO:K10577]
            101255113  SUMO-conjugating enzyme SCE1-like [KO:K10577]
            101253512  nuclear pore complex protein NUP85 isoform X1 [KO:K14304]
            101265789  protein transport protein SEC13 homolog B [KO:K14004]
            101257847  protein transport protein SEC13 homolog B [KO:K14004]
            101260210  nuclear pore complex protein NUP107 [KO:K14301]
            101253396  nuclear pore complex protein NUP133 [KO:K14300]
            101261437  protein SEH1 [KO:K14299]
            101252300  nuclear pore complex protein NUP43 [KO:K14305]
            101264859  nucleoporin-like protein [KO:K14306]
            101255050  nuclear pore complex protein NUP58 [KO:K14307]
            101253565  nuclear pore complex protein NUP54 [KO:K14308]
            101260798  nuclear pore complex protein NUP205 [KO:K14310]
            101245721  uncharacterized protein LOC101245721 isoform X2 [KO:K14311]
            101246938  nuclear pore complex protein NUP155 [KO:K14312]
            101262406  nuclear pore complex protein NUP93A [KO:K14309]
            101258447  nuclear pore complex protein NUP35 [KO:K14313]
            101265714  uncharacterized protein LOC101265714 [KO:K14315]
            101260108  nuclear pore complex protein GP210 [KO:K14314]
            101256070  uncharacterized protein LOC101256070 [KO:K20724]
            101248882  nuclear-pore anchor [KO:K09291]
            101247351  uncharacterized protein LOC101247351 isoform X4 [KO:K14295]
            543535  Kap-alpha1; importin subunit alpha [KO:K15042]
            101257502  importin subunit alpha-2 [KO:K15042]
            101261940  importin subunit alpha-2 [KO:K15042]
            101253727  importin subunit alpha-4 [KO:K15042]
            101251047  importin subunit alpha-9 [KO:K15042]
            101263498  importin subunit beta-1 [KO:K14293]
            101258299  importin subunit beta-1 [KO:K14293]
            101245551  importin subunit beta-1-like [KO:K14293]
            101246483  transportin-1 isoform X1 [KO:K18752]
            101246063  transportin MOS14 isoform X1 [KO:K15436]
            101256535  transportin MOS14 isoform X1 [KO:K15436]
            101252925  importin-4 [KO:K20221]
            101262450  importin-5 [KO:K20222]
            101246889  importin-5-like [KO:K20222]
            101253519  importin-5-like [KO:K20222]
            101260377  importin beta-like SAD2 [KO:K20223]
            101246715  importin-9 [KO:K20224]
            101256320  importin-11 [KO:K25201]
            101261543  snurportin-1 [KO:K13151]
            100313952  Xpo1; exportin 1 [KO:K14290]
            101255034  exportin-2 [KO:K18423]
            101251762  exportin-T isoform X2 [KO:K14288]
            101259130  exportin-4 isoform X2 [KO:K25203]
            101250741  protein HASTY 1 [KO:K14289]
            101262148  exportin-7 isoform X2 [KO:K18460]
            778290  RAN2A; GTP-binding nuclear protein Ran2 [KO:K07936]
            778289  RAN1; GTP-binding nuclear protein Ran1 [KO:K07936]
            778291  RAN2B; GTP-binding nuclear protein Ran2 [KO:K07936]
            101264700  elongation factor 1-alpha [KO:K03231]
            544055  elongation factor 1-alpha [KO:K03231]
            101244084  elongation factor 1-alpha [KO:K03231]
            101259242  uncharacterized protein LOC101259242 isoform X1 [KO:K14291]
            101249122  nuclear cap-binding protein subunit 1 [KO:K12882]
            101268545  nuclear cap-binding protein subunit 2 [KO:K12883]
            101253905  60S ribosomal export protein NMD3 [KO:K07562]
            101248886  RNA-binding protein 8A-like [KO:K12876]
            101268456  protein mago nashi homolog [KO:K12877]
            101256152  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:3.6.4.13]
            101245055  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
            101260232  histone deacetylase complex subunit SAP18 [KO:K14324]
            101257116  serine/arginine-rich splicing factor SR45 isoform X2 [KO:K14325]
            101248146  pinin [KO:K13114]
            101268859  THO complex subunit 4D-like isoform X2 [KO:K12881]
            101256343  THO complex subunit 4D [KO:K12881]
            101262878  THO complex subunit 4A [KO:K12881]
            101266904  RNA-binding (RRM/RBD/RNP motifs) family protein [KO:K12881]
            101253276  regulator of nonsense transcripts UPF2 isoform X1 [KO:K14327]
            101264766  regulator of nonsense transcripts UPF3 [KO:K14328]
            101263168  regulator of nonsense transcripts UPF3-like isoform X3 [KO:K14328]
            101261336  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:3.6.4.13]
            101259772  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:3.6.4.13]
            101263053  serine/arginine repetitive matrix protein 1 [KO:K13171]
            101261756  partner of Y14 and mago [KO:K14294]
            101245499  THO complex subunit 1 isoform X3 [KO:K12878]
            101261518  THO complex subunit 2 [KO:K12879]
            101252484  THO complex subunit 5A [KO:K13174]
            101264535  THO complex subunit 6 isoform X1 [KO:K13175]
            101254930  THO complex subunit 7A [KO:K13176]
            101268064  THO complex subunit 7A [KO:K13176]
            101265940  THO complex subunit 3 [KO:K12880]
REFERENCE   PMID:16777596
  AUTHORS   Tran EJ, Wente SR
  TITLE     Dynamic nuclear pore complexes: life on the edge.
  JOURNAL   Cell 125:1041-53 (2006)
            DOI:10.1016/j.cell.2006.05.027
REFERENCE   PMID:15519698
  AUTHORS   Rodriguez MS, Dargemont C, Stutz F
  TITLE     Nuclear export of RNA.
  JOURNAL   Biol Cell 96:639-55 (2004)
            DOI:10.1016/j.biolcel.2004.04.014
REFERENCE   PMID:18313922
  AUTHORS   Palancade B, Doye V
  TITLE     Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  JOURNAL   Trends Cell Biol 18:174-83 (2008)
            DOI:10.1016/j.tcb.2008.02.001
REFERENCE   PMID:15901496
  AUTHORS   Reed R, Cheng H
  TITLE     TREX, SR proteins and export of mRNA.
  JOURNAL   Curr Opin Cell Biol 17:269-73 (2005)
            DOI:10.1016/j.ceb.2005.04.011
REFERENCE   PMID:16314458
  AUTHORS   Tange TO, Shibuya T, Jurica MS, Moore MJ
  TITLE     Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  JOURNAL   RNA 11:1869-83 (2005)
            DOI:10.1261/rna.2155905
REFERENCE   PMID:28673770
  AUTHORS   Beck M, Schirmacher P, Singer S
  TITLE     Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  JOURNAL   J Hepatol 67:1051-1061 (2017)
            DOI:10.1016/j.jhep.2017.06.021
REL_PATHWAY sly03015  mRNA surveillance pathway
KO_PATHWAY  ko03013
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