ENTRY       sly01230                    Pathway
NAME        Biosynthesis of amino acids - Solanum lycopersicum (tomato)
DESCRIPTION This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
PATHWAY_MAP sly01230  Biosynthesis of amino acids
MODULE      sly_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sly01230]
            sly_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sly01230]
            sly_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:sly01230]
            sly_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sly01230]
            sly_M00015  Proline biosynthesis, glutamate => proline [PATH:sly01230]
            sly_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sly01230]
            sly_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sly01230]
            sly_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sly01230]
            sly_M00021  Cysteine biosynthesis, serine => cysteine [PATH:sly01230]
            sly_M00022  Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:sly01230]
            sly_M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:sly01230]
            sly_M00026  Histidine biosynthesis, PRPP => histidine [PATH:sly01230]
            sly_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:sly01230]
            sly_M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine [PATH:sly01230]
            sly_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sly01230]
            sly_M00527  Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:sly01230]
            sly_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sly01230]
            sly_M00844  Arginine biosynthesis, ornithine => arginine [PATH:sly01230]
            sly_M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine [PATH:sly01230]
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
KO_PATHWAY  ko01230
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