ENTRY       sly01210                    Pathway
NAME        2-Oxocarboxylic acid metabolism - Solanum lycopersicum (tomato)
DESCRIPTION 2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
PATHWAY_MAP sly01210  2-Oxocarboxylic acid metabolism
MODULE      sly_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sly01210]
            sly_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sly01210]
            sly_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:sly01210]
            sly_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sly01210]
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
REL_PATHWAY sly00020  Citrate cycle (TCA cycle)
            sly00220  Arginine biosynthesis
            sly00260  Glycine, serine and threonine metabolism
            sly00290  Valine, leucine and isoleucine biosynthesis
            sly00300  Lysine biosynthesis
            sly00966  Glucosinolate biosynthesis
KO_PATHWAY  ko01210
///
