ENTRY       sly00996                    Pathway
NAME        Biosynthesis of various alkaloids - Solanum lycopersicum (tomato)
  INCLUDING Cucurbitacin biosynthesis, Solanine and tomatine biosynthesis, Ephedrine biosynthesis, Capsaicin biosynthesis, Acridone alkaloid biosynthesis
CLASS       Metabolism; Biosynthesis of other secondary metabolites
PATHWAY_MAP sly00996  Biosynthesis of various alkaloids
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101255011  cytochrome P450 CYP72A219 [KO:K25489] [EC:1.14.14.-]
            544002  gad2; 2-oxoglutarate-dependent dioxygenase 2 [KO:K25492] [EC:1.14.11.-]
            101246190  hyoscyamine 6-dioxygenase-like [KO:K25492] [EC:1.14.11.-]
            101258391  gamma aminobutyrate transaminase 2-like [KO:K24276] [EC:2.6.1.119]
            101255851  acylsugar acyltransferase 3-like [KO:K24277] [EC:2.3.2.35]
            101256149  acylsugar acyltransferase 3-like [KO:K24277] [EC:2.3.2.35]
COMPOUND    C00024  Acetyl-CoA
            C00074  Phosphoenolpyruvate
            C00078  L-Tryptophan
            C00079  L-Phenylalanine
            C00083  Malonyl-CoA
            C00108  Anthranilate
            C00180  Benzoate
            C00187  Cholesterol
            C00223  p-Coumaroyl-CoA
            C00251  Chorismate
            C00254  Prephenate
            C00323  Caffeoyl-CoA
            C00406  Feruloyl-CoA
            C00423  trans-Cinnamate
            C00493  Shikimate
            C00630  2-Methylpropanoyl-CoA
            C00751  Squalene
            C00755  4-Hydroxy-3-methoxy-benzaldehyde
            C00805  Salicylate
            C01054  (S)-2,3-Epoxysqualene
            C01575  Ephedrine
            C01897  Camptothecin
            C02765  (+)-(1S,2S)-Pseudoephedrine
            C03005  N-Methylanthranilate
            C03470  3-alpha(S)-Strictosidine
            C04351  (R)-2-Methylimino-1-phenylpropan-1-ol
            C06332  N-Acetylanthranilate
            C06528  Cinchonine
            C06543  Solanidine
            C06866  Capsaicin
            C07303  4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
            C08300  D-Cathine
            C08301  D-Cathinone
            C08624  Euphol
            C08627  Hopane-29-acetate
            C08748  Azadirachtin A
            C08794  Cucurbitacin B
            C08795  Cucurbitacin C
            C08796  Cucurbitacin D
            C08797  Cucurbitacin E
            C08800  Cucurbitacin I
            C10632  Acronycine
            C10660  Dictamnine
            C10722  Melicopicine
            C10733  Peganine
            C10738  Rutacridone
            C10740  Skimmianine
            C10820  Solanine
            C10826  Tomatidine
            C10827  Tomatine
            C11379  Cinchonidine
            C12092  N-Methylanthraniloyl-CoA
            C12093  1,3-Dihydroxy-N-methylacridone
            C16666  Vanillylamine
            C16716  4-Hydroxy-2-quinolone
            C16719  (-)-Norephedrine
            C16721  Platydesmine
            C16723  Pumiloside
            C16724  Strictosamide
            C16725  Deoxypumiloside
            C16726  Cinchoninone
            C16727  Cinchonamine
            C16735  Corynantheal
            C17268  Pyruvophenone
            C18202  8-Methyl-6-nonenoic acid
            C19819  Cucurbitadienol
            C21841  11-Oxocucurbitadienol
            C22289  (6E)-8-Methylnon-6-enoyl-CoA
            C22433  19-Hydroxycucurbitadienol
            C22434  19,25-Dihydroxycucurbitadienol
            C22435  Deacetylcucurbitacin C
            C22436  11-Carbonyl-20beta-hydroxycucurbitadienol
            C22437  11-Carbonyl-2beta,20beta-dihydroxycucurbitadienol
            C22446  22-Hydroxycholesterol
            C22447  22,26-Dihydroxycholesterol
            C22448  16alpha,22,26-Trihydroxycholesterol
REFERENCE   PMID:27892922
  AUTHORS   Zhou Y, Ma Y, Zeng J, Duan L, Xue X, Wang H, Lin T, Liu Z, Zeng K, Zhong Y, Zhang S, Hu Q, Liu M, Zhang H, Reed J, Moses T, Liu X, Huang P, Qing Z, Liu X, Tu P, Kuang H, Zhang Z, Osbourn A, Ro DK, Shang Y, Huang S.
  TITLE     Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae.
  JOURNAL   Nat Plants 2:16183 (2016)
            DOI:10.1038/nplants.2016.183
REFERENCE   PMID:28754839
  AUTHORS   Nakayasu M, Umemoto N, Ohyama K, Fujimoto Y, Lee HJ, Watanabe B, Muranaka T, Saito K, Sugimoto Y, Mizutani M.
  TITLE     A Dioxygenase Catalyzes Steroid 16alpha-Hydroxylation in Steroidal Glycoalkaloid  Biosynthesis.
  JOURNAL   Plant Physiol 175:120-133 (2017)
            DOI:10.1104/pp.17.00501
REFERENCE   PMID:19553373
  AUTHORS   Mazourek M, Pujar A, Borovsky Y, Paran I, Mueller L, Jahn MM
  TITLE     A dynamic interface for capsaicinoid systems biology.
  JOURNAL   Plant Physiol 150:1806-21 (2009)
            DOI:10.1104/pp.109.136549
REFERENCE   PMID:10217426
  AUTHORS   Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  TITLE     Native acridone synthases I and II from Ruta graveolens L. form homodimers
  JOURNAL   FEBS Lett 448:135-40 (1999)
            DOI:10.1016/S0014-5793(99)00355-5
REFERENCE   PMID:16874388
  AUTHORS   O'Connor SE, Maresh JJ.
  TITLE     Chemistry and biology of monoterpene indole alkaloid biosynthesis.
  JOURNAL   Nat Prod Rep 23:532-47 (2006)
            DOI:10.1039/b512615k
REL_PATHWAY sly00010  Glycolysis / Gluconeogenesis
            sly00100  Steroid biosynthesis
            sly00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            sly00940  Phenylpropanoid biosynthesis
KO_PATHWAY  ko00996
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