ENTRY       sly00908                    Pathway
NAME        Zeatin biosynthesis - Solanum lycopersicum (tomato)
DESCRIPTION Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
CLASS       Metabolism; Metabolism of terpenoids and polyketides
PATHWAY_MAP sly00908  Zeatin biosynthesis
DBLINKS     GO: 0009691
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        104644794  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101246596  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101251547  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            100874541  IPT1; adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101245611  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101246020  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101246496  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101264142  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101265353  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            112940273  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            109118913  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101245726  LOW QUALITY PROTEIN: adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            112940274  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            112940065  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            112940050  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101252651  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101265049  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101265662  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            100874542  IPT2; adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            100874543  IPT4; adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101259193  IPT3; adenylate isopentenyltransferase 3 [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            101055578  CYP735A2; cytokinin hydroxylase-like [KO:K10717]
            101055577  CYP735A1; cytokinin hydroxylase-like [KO:K10717]
            101055598  CKX1; cytokinin oxidase/dehydrogenase-like [KO:K00279] [EC:1.5.99.12]
            101266491  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
            101055579  cytokinin dehydrogenase 3 isoform X1 [KO:K00279] [EC:1.5.99.12]
            100874536  CKX7; cytokinin oxidase/dehydrogenase-like 7 precursor [KO:K00279] [EC:1.5.99.12]
            101255039  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
            101055612  CKX4; cytokinin oxidase/dehydrogenase-like precursor [KO:K00279] [EC:1.5.99.12]
            100874535  CKX5; cytokinin oxidase/dehydrogenase-like 5 precursor [KO:K00279] [EC:1.5.99.12]
            100874537  CKX2; cytokinin oxidase/dehydrogenase-like 2 [KO:K00279] [EC:1.5.99.12]
            101244307  CKX3; cytokinin oxidase/dehydrogenase 3 precursor [KO:K00279] [EC:1.5.99.12]
            101267366  UDP-glycosyltransferase 73C5 [KO:K13496] [EC:2.4.1.-]
            101257246  UDP-glycosyltransferase 73C1 [KO:K13496] [EC:2.4.1.-]
            101261181  UGT73C4; UDP-glycosyltransferase 73C4 [KO:K13496] [EC:2.4.1.-]
            101244676  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
            101254417  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
            101260441  UDP-glycosyltransferase 73C3 [KO:K13496] [EC:2.4.1.-]
            101261675  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
            101258827  tRNA dimethylallyltransferase 9 [KO:K00791] [EC:2.5.1.75]
            100874544  IPT5; adenylate isopentenyltransferase [KO:K00791] [EC:2.5.1.75]
            101259234  zeatin O-xylosyltransferase [KO:K13495] [EC:2.4.1.215]
            101248187  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101263600  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101252238  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101253738  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101244725  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101246295  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101247108  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101247699  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101248301  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101249176  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101251633  zeatin O-xylosyltransferase isoform X1 [KO:K13495] [EC:2.4.1.215]
            101254400  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101254402  zeatin O-xylosyltransferase [KO:K13495] [EC:2.4.1.215]
            101256765  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101258941  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101261904  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101262709  zeatin O-xylosyltransferase [KO:K13495] [EC:2.4.1.215]
            101263012  zeatin O-xylosyltransferase [KO:K13495] [EC:2.4.1.215]
            101263304  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101265026  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
            101265039  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101265706  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101268254  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            101268547  zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            104648079  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
COMPOUND    C00002  ATP
            C00008  ADP
            C00015  UDP
            C00019  S-Adenosyl-L-methionine
            C00020  AMP
            C00029  UDP-glucose
            C00033  Acetate
            C00147  Adenine
            C00170  5'-Methylthioadenosine
            C00190  UDP-D-xylose
            C00235  Dimethylallyl diphosphate
            C00371  Zeatin
            C00979  O-Acetyl-L-serine
            C01513  Lupinate
            C01804  Discadenine
            C02029  Dihydrozeatin
            C03300  O-beta-D-Xylosylzeatin
            C03423  O-beta-D-Glucosylzeatin
            C04083  N6-(Delta2-Isopentenyl)-adenine
            C04432  tRNA containing 6-isopentenyladenosine
            C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
            C07330  3-Methyl-2-butenal
            C15545  cis-Zeatin
            C15546  O-beta-D-Glucopyranosyl-cis-zeatin
            C16424  Isopentenyladenosine-5'-triphosphate
            C16426  Isopentenyladenosine-5'-diphosphate
            C16427  Isopentenyl adenosine
            C16428  trans-Zeatin riboside triphosphate
            C16429  trans-Zeatin riboside diphosphate
            C16430  trans-Zeatin riboside monophosphate
            C16431  trans-Zeatin riboside
            C16441  cis-Zeatin riboside monophosphate
            C16443  trans-Zeatin-7-beta-D-glucoside
            C16445  Dihydrozeatin riboside monophosphate
            C16447  Dihydrozeatin riboside
            C16448  Dihydrozeatin-O-glucoside
            C16449  cis-Zeatin riboside
            C16467  cis-Prenyl-tRNA
            C17324  tRNA adenine
REFERENCE   PMID:14726522
  AUTHORS   Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  TITLE     Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  JOURNAL   J Biol Chem 279:14049-54 (2004)
            DOI:10.1074/jbc.M314195200
REFERENCE   PMID:11313355
  AUTHORS   Takei K, Sakakibara H, Sugiyama T.
  TITLE     Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  JOURNAL   J Biol Chem 276:26405-10 (2001)
            DOI:10.1074/jbc.M102130200
REFERENCE   PMID:11479373
  AUTHORS   Kakimoto T.
  TITLE     Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  JOURNAL   Plant Cell Physiol 42:677-85 (2001)
            DOI:10.1093/pcp/pce112
REFERENCE   PMID:15280363
  AUTHORS   Takei K, Yamaya T, Sakakibara H.
  TITLE     Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  JOURNAL   J Biol Chem 279:41866-72 (2004)
            DOI:10.1074/jbc.M406337200
REFERENCE   PMID:15342621
  AUTHORS   Hou B, Lim EK, Higgins GS, Bowles DJ.
  TITLE     N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  JOURNAL   J Biol Chem 279:47822-32 (2004)
            DOI:10.1074/jbc.M409569200
REFERENCE   PMID:9874810
  AUTHORS   Martin RC, Mok MC, Mok DW
  TITLE     Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  JOURNAL   Proc Natl Acad Sci U S A 96:284-9 (1999)
            DOI:10.1073/pnas.96.1.284
REFERENCE   PMID:10364407
  AUTHORS   Martin RC, Mok MC, Mok DW
  TITLE     A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  JOURNAL   Plant Physiol 120:553-8 (1999)
            DOI:10.1104/pp.120.2.553
REFERENCE   PMID:12644686
  AUTHORS   Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  TITLE     O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  JOURNAL   Plant Physiol 131:1374-80 (2003)
            DOI:10.1104/pp.017210
REFERENCE   PMID:14555694
  AUTHORS   Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  TITLE     Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  JOURNAL   Plant Cell 15:2532-50 (2003)
            DOI:10.1105/tpc.014928
REFERENCE   PMID:17062755
  AUTHORS   Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  TITLE     Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  JOURNAL   Proc Natl Acad Sci U S A 103:16598-603 (2006)
            DOI:10.1073/pnas.0603522103
REL_PATHWAY sly00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko00908
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