ENTRY       sly00480                    Pathway
NAME        Glutathione metabolism - Solanum lycopersicum (tomato)
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP sly00480  Glutathione metabolism
MODULE      sly_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:sly00480]
DBLINKS     GO: 0006749
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101250409  glutathione hydrolase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            101263185  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            101259958  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
            101258241  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
            101246397  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
            101246654  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
            543536  GSH1; glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
            543537  GSH2; glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
            101263597  leucine aminopeptidase 1, chloroplastic [KO:K01255] [EC:3.4.11.1]
            544017  LAPA1; leucine aminopeptidase 1, chloroplastic [KO:K01255] [EC:3.4.11.1]
            544277  LAPA2; leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
            101253814  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
            101264198  LOW QUALITY PROTEIN: glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
            101256467  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
            101267956  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
            101265881  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
            101263072  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            101248761  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
            101259327  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
            101262815  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
            101262552  glutathione S-transferase L3 isoform X1 [KO:K00799] [EC:2.5.1.18]
            101255298  glutathione S-transferase U17 isoform X1 [KO:K00799] [EC:2.5.1.18]
            101256964  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
            101266084  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101253845  glutathione S-transferase L3 isoform X1 [KO:K00799] [EC:2.5.1.18]
            101245181  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101265520  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            101266195  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
            101265897  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101253468  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100037735  gst; glutathione-S-transferase [KO:K00799] [EC:2.5.1.18]
            100134894  glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
            101244597  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101245473  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
            101249765  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            101250053  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101250402  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
            101253422  glutathione S-transferase PARB [KO:K00799] [EC:2.5.1.18]
            101255036  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101255338  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101256677  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
            101257702  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
            101258000  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            101258631  glutathione S-transferase L1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
            101260846  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            101265268  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101265571  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101265853  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101266149  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101266488  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
            101266706  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101266750  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101266972  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101267339  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101267638  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101268216  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101268500  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            543814  uncharacterized LOC543814 [KO:K00799] [EC:2.5.1.18]
            543813  uncharacterized protein LOC543813 [KO:K00799] [EC:2.5.1.18]
            543815  uncharacterized protein LOC543815 [KO:K00799] [EC:2.5.1.18]
            543628  BI-GST/GPX; glutathione S-transferase/peroxidase [KO:K00799] [EC:2.5.1.18]
            543836  glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
            543816  GST-T4; putative glutathione S-transferase T4 [KO:K00799] [EC:2.5.1.18]
            543817  uncharacterized protein LOC543817 [KO:K00799] [EC:2.5.1.18]
            101256384  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101249821  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
            112940020  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
            101244013  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101244300  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
            101244886  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101264661  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
            101261142  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            101267923  LOW QUALITY PROTEIN: probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101264963  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            101266443  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            778229  DHAR1; dehydroascorbate reductase 1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            778343  DHAR2; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            101254215  uncharacterized protein LOC101254215 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100301931  GR; glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
            100301935  GR1; glutathione reductase [KO:K00383] [EC:1.8.1.7]
            101268602  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101255848  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101248445  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
            101256373  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101263001  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101247915  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101258494  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101249507  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101253589  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101258470  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101267388  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
            101267727  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            544197  GPXle-1; probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            101267098  GPXle-2; glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            544261  phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            101248896  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            101260517  1-Cys peroxiredoxin A [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
            544209  ODC; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            101255673  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
            101265415  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
            101263807  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
            101247725  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
            544177  spdsyn; spermidine synthase [KO:K00797] [EC:2.5.1.16]
            543894  SPM1; SPM1 protein [KO:K00797] [EC:2.5.1.16]
            101263901  thylakoid lumenal 29 kDa protein, chloroplastic-like [KO:K00434] [EC:1.11.1.11]
            101264282  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            778224  APX2; cytosolic ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
            778341  APX6; thylakoid-bound ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
            101258987  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
            101264583  L-ascorbate peroxidase 5 [KO:K00434] [EC:1.11.1.11]
            101262528  APX7; stromal ascorbate peroxidase 7 [KO:K00434] [EC:1.11.1.11]
            101264261  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
            778223  APX1; cytosolic ascorbate peroxidase 1 [KO:K00434] [EC:1.11.1.11]
            101257790  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
            101249065  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
            101263997  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
            101261156  ribonucleoside-diphosphate reductase small chain A-like [KO:K10808] [EC:1.17.4.1]
            101268630  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
COMPOUND    C00005  NADPH
            C00006  NADP+
            C00024  Acetyl-CoA
            C00025  L-Glutamate
            C00037  Glycine
            C00051  Glutathione
            C00072  Ascorbate
            C00077  L-Ornithine
            C00097  L-Cysteine
            C00127  Glutathione disulfide
            C00134  Putrescine
            C00151  L-Amino acid
            C00315  Spermidine
            C00669  gamma-L-Glutamyl-L-cysteine
            C00750  Spermine
            C01322  RX
            C01419  Cys-Gly
            C01672  Cadaverine
            C01879  5-Oxoproline
            C02090  Trypanothione
            C02320  R-S-Glutathione
            C03170  Trypanothione disulfide
            C03646  Bis-gamma-glutamylcystine
            C03740  (5-L-Glutamyl)-L-amino acid
            C05422  Dehydroascorbate
            C05726  S-Substituted L-cysteine
            C05727  S-Substituted N-acetyl-L-cysteine
            C05729  R-S-Cysteinylglycine
            C05730  Glutathionylspermidine
            C16562  Glutathionylspermine
            C16563  Bis(glutathionyl)spermine
            C16564  Bis(glutathionyl)spermine disulfide
            C16565  Aminopropylcadaverine
            C16566  Glutathionylaminopropylcadaverine
            C16567  Homotrypanothione
            C16568  Homotrypanothione disulfide
            C16663  Tryparedoxin
            C16664  Tryparedoxin disulfide
REFERENCE   PMID:12675513
  AUTHORS   Josch C, Klotz LO, Sies H.
  TITLE     Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  JOURNAL   Biol Chem 384:213-8 (2003)
            DOI:10.1515/BC.2003.023
REFERENCE   PMID:18482986
  AUTHORS   Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  TITLE     A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  JOURNAL   J Biol Chem 283:19351-8 (2008)
            DOI:10.1074/jbc.M801034200
REFERENCE   PMID:14583094
  AUTHORS   Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  TITLE     New role for leucyl aminopeptidase in glutathione turnover.
  JOURNAL   Biochem J 378:35-44 (2004)
            DOI:10.1042/BJ20031336
REFERENCE   PMID:11157967
  AUTHORS   Suzuki H, Kamatani S, Kim ES, Kumagai H.
  TITLE     Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  JOURNAL   J Bacteriol 183:1489-90 (2001)
            DOI:10.1128/JB.183.4.1489-1490.2001
REFERENCE   PMID:15610825
  AUTHORS   Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  TITLE     Trypanothione biosynthesis in Leishmania major.
  JOURNAL   Mol Biochem Parasitol 139:107-16 (2005)
            DOI:10.1016/j.molbiopara.2004.10.004
REFERENCE   PMID:12049631
  AUTHORS   Oza SL, Ariyanayagam MR, Fairlamb AH.
  TITLE     Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  JOURNAL   Biochem J 364:679-86 (2002)
            DOI:10.1042/BJ20011370
REFERENCE   PMID:9677355
  AUTHORS   Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  TITLE     Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  JOURNAL   J Biol Chem 273:19383-90 (1998)
            DOI:10.1074/jbc.273.31.19383
REFERENCE   PMID:12750367
  AUTHORS   Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  TITLE     Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 278:27612-9 (2003)
            DOI:10.1074/jbc.M302750200
REFERENCE   PMID:12967709
  AUTHORS   Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  TITLE     Properties of trypanothione synthetase from Trypanosoma brucei.
  JOURNAL   Mol Biochem Parasitol 131:25-33 (2003)
            DOI:10.1016/S0166-6851(03)00176-2
REFERENCE   PMID:12121990
  AUTHORS   Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  TITLE     A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 277:35853-61 (2002)
            DOI:10.1074/jbc.M204403200
REFERENCE   PMID:15537651
  AUTHORS   Comini M, Menge U, Wissing J, Flohe L.
  TITLE     Trypanothione synthesis in crithidia revisited.
  JOURNAL   J Biol Chem 280:6850-60 (2005)
            DOI:10.1074/jbc.M404486200
REFERENCE   PMID:7813456
  AUTHORS   Hunter KJ, Le Quesne SA, Fairlamb AH.
  TITLE     Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  JOURNAL   Eur J Biochem 226:1019-27 (1994)
            DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
REFERENCE   PMID:12751784
  AUTHORS   Krauth-Siegel RL, Meiering SK, Schmidt H.
  TITLE     The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  JOURNAL   Biol Chem 384:539-49 (2003)
            DOI:10.1515/BC.2003.062
REFERENCE   PMID:18395526
  AUTHORS   Krauth-Siegel RL, Comini MA.
  TITLE     Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  JOURNAL   Biochim Biophys Acta 1780:1236-48 (2008)
            DOI:10.1016/j.bbagen.2008.03.006
REFERENCE   PMID:8892297
  AUTHORS   Krauth-Siegel RL, Ludemann H.
  TITLE     Reduction of dehydroascorbate by trypanothione.
  JOURNAL   Mol Biochem Parasitol 80:203-8 (1996)
            DOI:10.1016/0166-6851(96)02689-8
REFERENCE   PMID:11150302
  AUTHORS   Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  TITLE     Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  JOURNAL   J Biol Chem 276:10602-6 (2001)
            DOI:10.1074/jbc.M010352200
REFERENCE   PMID:12949079
  AUTHORS   Schmidt H, Krauth-Siegel RL.
  TITLE     Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  JOURNAL   J Biol Chem 278:46329-36 (2003)
            DOI:10.1074/jbc.M305338200
REFERENCE   PMID:9851611
  AUTHORS   Tetaud E, Fairlamb AH.
  TITLE     Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  JOURNAL   Mol Biochem Parasitol 96:111-23 (1998)
            DOI:10.1016/S0166-6851(98)00120-0
REFERENCE   PMID:12446213
  AUTHORS   Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  TITLE     Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  JOURNAL   Free Radic Biol Med 33:1552-62 (2002)
            DOI:10.1016/S0891-5849(02)01089-4
REFERENCE   PMID:10713147
  AUTHORS   Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  TITLE     Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 275:8220-5 (2000)
            DOI:10.1074/jbc.275.11.8220
REFERENCE   PMID:17922848
  AUTHORS   Konig J, Fairlamb AH.
  TITLE     A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  JOURNAL   FEBS J 274:5643-58 (2007)
            DOI:10.1111/j.1742-4658.2007.06087.x
REFERENCE   PMID:12466271
  AUTHORS   Hillebrand H, Schmidt A, Krauth-Siegel RL.
  TITLE     A second class of peroxidases linked to the trypanothione metabolism.
  JOURNAL   J Biol Chem 278:6809-15 (2003)
            DOI:10.1074/jbc.M210392200
REFERENCE   PMID:14982633
  AUTHORS   Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  TITLE     Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  JOURNAL   Mol Microbiol 51:1401-12 (2004)
            DOI:10.1046/j.1365-2958.2003.03913.x
REFERENCE   PMID:6798961
  AUTHORS   Pegg AE, Shuttleworth K, Hibasami H.
  TITLE     Specificity of mammalian spermidine synthase and spermine synthase.
  JOURNAL   Biochem J 197:315-20 (1981)
            DOI:10.1042/bj1970315
REL_PATHWAY sly00220  Arginine biosynthesis
            sly00250  Alanine, aspartate and glutamate metabolism
            sly00270  Cysteine and methionine metabolism
            sly00430  Taurine and hypotaurine metabolism
            sly00460  Cyanoamino acid metabolism
KO_PATHWAY  ko00480
///
