ENTRY       sly00290                    Pathway
NAME        Valine, leucine and isoleucine biosynthesis - Solanum lycopersicum (tomato)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP sly00290  Valine, leucine and isoleucine biosynthesis
MODULE      sly_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sly00290]
            sly_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sly00290]
            sly_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sly00290]
DBLINKS     GO: 0009097 0009098 0009099
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        543983  TD2; threonine dehydratase 2 biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            101244823  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
            100037737  chloroplast threonine deaminase 1 precursor [KO:K01754] [EC:4.3.1.19]
            101266391  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
            101244614  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
            101250813  3-isopropylmalate dehydratase small subunit 3 [KO:K01704] [EC:4.2.1.33 4.2.1.35]
            101247914  3-isopropylmalate dehydrogenase, chloroplastic [KO:K00052] [EC:1.1.1.85]
            101247891  acetolactate synthase 2, chloroplastic [KO:K01652] [EC:2.2.1.6]
            101268696  acetolactate synthase 1, chloroplastic-like [KO:K01652] [EC:2.2.1.6]
            101254112  acetolactate synthase 2, chloroplastic-like [KO:K01652] [EC:2.2.1.6]
            101265999  acetolactate synthase small subunit 1, chloroplastic [KO:K01653] [EC:2.2.1.6]
            101252944  acetolactate synthase small subunit 1, chloroplastic [KO:K01653] [EC:2.2.1.6]
            101257242  ketol-acid reductoisomerase, chloroplastic-like [KO:K00053] [EC:1.1.1.86]
            101261134  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
            101246533  dihydroxy-acid dehydratase, chloroplastic [KO:K01687] [EC:4.2.1.9]
            101264707  dihydroxy-acid dehydratase-like [KO:K01687] [EC:4.2.1.9]
            101261313  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
            101245812  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
            101251085  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
            101253875  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            101265804  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
            101254608  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
            101245066  2-isopropylmalate synthase B [KO:K01649] [EC:2.3.3.13]
            101251907  IPMS2; isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
            101252796  2-isopropylmalate synthase A-like [KO:K01649] [EC:2.3.3.13]
            104648641  2-isopropylmalate synthase A-like [KO:K01649] [EC:2.3.3.13]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00109  2-Oxobutanoate
            C00123  L-Leucine
            C00141  3-Methyl-2-oxobutanoic acid
            C00183  L-Valine
            C00188  L-Threonine
            C00233  4-Methyl-2-oxopentanoate
            C00407  L-Isoleucine
            C00671  (S)-3-Methyl-2-oxopentanoic acid
            C02226  2-Methylmaleate
            C02504  alpha-Isopropylmalate
            C02612  (R)-2-Methylmalate
            C02631  2-Isopropylmaleate
            C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
            C04236  (2S)-2-Isopropyl-3-oxosuccinate
            C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
            C04411  (2R,3S)-3-Isopropylmalate
            C06006  (S)-2-Aceto-2-hydroxybutanoate
            C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
            C06010  (S)-2-Acetolactate
            C06032  D-erythro-3-Methylmalate
            C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
REFERENCE   PMID:15292141
  AUTHORS   Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  TITLE     Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  JOURNAL   J Bacteriol 186:5400-9 (2004)
            DOI:10.1128/JB.186.16.5400-5409.2004
REL_PATHWAY sly00260  Glycine, serine and threonine metabolism
            sly00280  Valine, leucine and isoleucine degradation
            sly00620  Pyruvate metabolism
KO_PATHWAY  ko00290
///
