ENTRY       sly00260                    Pathway
NAME        Glycine, serine and threonine metabolism - Solanum lycopersicum (tomato)
DESCRIPTION Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP sly00260  Glycine, serine and threonine metabolism
MODULE      sly_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sly00260]
            sly_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sly00260]
            sly_M00555  Betaine biosynthesis, choline => betaine [PATH:sly00260]
DBLINKS     GO: 0006544 0006563 0070178 0006566
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101258399  aspartokinase 2, chloroplastic isoform X2 [KO:K00928] [EC:2.7.2.4]
            101258465  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            101264587  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            101258686  uncharacterized protein LOC101258686 [KO:K00133] [EC:1.2.1.11]
            101248664  homoserine kinase [KO:K00872] [EC:2.7.1.39]
            101260521  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
            101244777  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
            101247807  probable low-specificity L-threonine aldolase 1 isoform X2 [KO:K01620] [EC:4.1.2.48]
            101250548  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
            101254439  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
            101256090  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
            101264818  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
            101259725  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
            101267301  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
            101263138  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
            101055519  Hop-interacting protein THI032 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            100191110  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
            101251910  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            101263391  uncharacterized protein LOC101263391 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            101247124  uncharacterized protein LOC101247124 [KO:K01834] [EC:5.4.2.11]
            101265817  uncharacterized protein LOC101265817 isoform X4 [KO:K01834] [EC:5.4.2.11]
            101265096  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
            101248497  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            101244755  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
            101266918  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            101246616  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            101254848  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            101254553  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
            101264434  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
            101253862  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
            543808  cuAO; copper amine oxidase precursor [KO:K00276] [EC:1.4.3.21]
            101266123  uncharacterized protein LOC101266123 [KO:K00276] [EC:1.4.3.21]
            101253199  uncharacterized protein LOC101253199 [KO:K00276] [EC:1.4.3.21]
            101254319  uncharacterized protein LOC101254319 [KO:K00276] [EC:1.4.3.21]
            101263760  LOW QUALITY PROTEIN: primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
            101260070  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            101249137  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
            101245293  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            101246429  dihydrolipoyl dehydrogenase 1, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
            101245444  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
            544237  dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
            101257194  ADH11A4a; glycine cleavage system H protein, mitochondrial [KO:K02437]
            101258615  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
            101244882  glycine cleavage system H protein, mitochondrial [KO:K02437]
            101247011  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            101268729  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            101251709  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
            101265236  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
            101261534  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
            101249833  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
            100301929  amadh2; aminoaldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
            101253497  ADH10A9; putative betaine aldehyde dehyrogenase [KO:K00130] [EC:1.2.1.8]
            101252968  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            101265751  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            543983  TD2; threonine dehydratase 2 biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            101244823  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
            100037737  chloroplast threonine deaminase 1 precursor [KO:K01754] [EC:4.3.1.19]
            101261640  serine racemase-like [KO:K12235] [EC:5.1.1.18]
            101252608  serine racemase [KO:K12235] [EC:5.1.1.18]
            101252307  serine racemase-like [KO:K12235] [EC:5.1.1.18]
            101255433  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
            101256422  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
            101256529  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
            101249965  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
            101254921  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
            101261400  uncharacterized protein LOC101261400 [KO:K06001] [EC:4.2.1.20]
COMPOUND    C00011  CO2
            C00014  Ammonia
            C00022  Pyruvate
            C00037  Glycine
            C00048  Glyoxylate
            C00049  L-Aspartate
            C00065  L-Serine
            C00078  L-Tryptophan
            C00097  L-Cysteine
            C00101  Tetrahydrofolate
            C00109  2-Oxobutanoate
            C00114  Choline
            C00143  5,10-Methylenetetrahydrofolate
            C00168  Hydroxypyruvate
            C00188  L-Threonine
            C00197  3-Phospho-D-glycerate
            C00213  Sarcosine
            C00258  D-Glycerate
            C00263  L-Homoserine
            C00300  Creatine
            C00430  5-Aminolevulinate
            C00441  L-Aspartate 4-semialdehyde
            C00546  Methylglyoxal
            C00576  Betaine aldehyde
            C00581  Guanidinoacetate
            C00631  2-Phospho-D-glycerate
            C00719  Betaine
            C00740  D-Serine
            C00986  1,3-Diaminopropane
            C01005  O-Phospho-L-serine
            C01026  N,N-Dimethylglycine
            C01102  O-Phospho-L-homoserine
            C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
            C01888  Aminoacetone
            C02051  Lipoylprotein
            C02291  L-Cystathionine
            C02737  Phosphatidylserine
            C02972  Dihydrolipoylprotein
            C03082  4-Phospho-L-aspartate
            C03194  (R)-1-Aminopropan-2-ol
            C03232  3-Phosphonooxypyruvate
            C03283  L-2,4-Diaminobutanoate
            C03508  L-2-Amino-3-oxobutanoic acid
            C05519  L-Allothreonine
            C06231  Ectoine
            C06442  N(gamma)-Acetyldiaminobutyrate
            C16432  5-Hydroxyectoine
            C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:11823218
  AUTHORS   Kuhlmann AU, Bremer E.
  TITLE     Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  JOURNAL   Appl Environ Microbiol 68:772-83 (2002)
            DOI:10.1128/AEM.68.2.772-783.2002
REFERENCE   PMID:10473374
  AUTHORS   Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  TITLE     Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  JOURNAL   Appl Environ Microbiol 65:3774-9 (1999)
            DOI:10.1128/AEM.65.9.3774-3779.1999
REFERENCE   PMID:17636255
  AUTHORS   Bursy J, Pierik AJ, Pica N, Bremer E.
  TITLE     Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  JOURNAL   J Biol Chem 282:31147-55 (2007)
            DOI:10.1074/jbc.M704023200
REFERENCE   PMID:16707670
  AUTHORS   Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  TITLE     The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  JOURNAL   J Bacteriol 188:3774-84 (2006)
            DOI:10.1128/JB.00136-06
REFERENCE   PMID:15470257
  AUTHORS   Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  TITLE     FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  JOURNAL   Eukaryot Cell 3:1287-96 (2004)
            DOI:10.1128/EC.3.5.1287-1296.2004
REFERENCE   PMID:7639721
  AUTHORS   Rees WD, Hay SM
  TITLE     The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  JOURNAL   Biochem J 309 ( Pt 3):999-1007 (1995)
            DOI:10.1042/bj3090999
REFERENCE   PMID:11341914
  AUTHORS   Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  TITLE     Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  JOURNAL   Biochim Biophys Acta 1544:28-41 (2001)
            DOI:10.1016/S0167-4838(00)00203-X
REFERENCE   PMID:15520012
  AUTHORS   Chen X, Jhee KH, Kruger WD
  TITLE     Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  JOURNAL   J Biol Chem 279:52082-6 (2004)
            DOI:10.1074/jbc.C400481200
REL_PATHWAY sly00010  Glycolysis / Gluconeogenesis
            sly00020  Citrate cycle (TCA cycle)
            sly00230  Purine metabolism
            sly00250  Alanine, aspartate and glutamate metabolism
            sly00270  Cysteine and methionine metabolism
            sly00290  Valine, leucine and isoleucine biosynthesis
            sly00300  Lysine biosynthesis
            sly00330  Arginine and proline metabolism
            sly00460  Cyanoamino acid metabolism
            sly00470  D-Amino acid metabolism
            sly00564  Glycerophospholipid metabolism
            sly00600  Sphingolipid metabolism
            sly00620  Pyruvate metabolism
            sly00630  Glyoxylate and dicarboxylate metabolism
            sly00640  Propanoate metabolism
            sly00860  Porphyrin metabolism
            sly00920  Sulfur metabolism
KO_PATHWAY  ko00260
///
