ENTRY       sly00053                    Pathway
NAME        Ascorbate and aldarate metabolism - Solanum lycopersicum (tomato)
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP sly00053  Ascorbate and aldarate metabolism
MODULE      sly_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:sly00053]
DBLINKS     GO: 0019852 0019577 0019572
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101246311  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            101263958  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
            101261402  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
            101259257  UDP-glucose 6-dehydrogenase 5-like isoform X2 [KO:K00012] [EC:1.1.1.22]
            101247010  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
            101260589  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
            101254427  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
            101265809  inositol oxygenase 5-like [KO:K00469] [EC:1.13.99.1]
            101268447  probable inositol oxygenase isoform X1 [KO:K00469] [EC:1.13.99.1]
            100316875  MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
            101263222  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
            101267438  aldose reductase [KO:K00002] [EC:1.1.1.2]
            101256514  aldo-keto reductase 4B-like [KO:K00002] [EC:1.1.1.2]
            101261840  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
            101256030  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100316902  GME1; GDP-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100316874  GME2; GDP-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            101255942  GGP2; GDP-L-galactose phosphorylase [KO:K14190] [EC:2.7.7.69]
            101055572  GGP; GDP-L-galactose phosphorylase [KO:K14190] [EC:2.7.7.69]
            544014  IMP2; inositol monophosphatase 2 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            544280  IMP1; inositol monophosphatase 1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            544013  IMP3; inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            101254644  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
            101254135  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
            544206  gldh; L-galactono-1,4-lactone dehydrogenase [KO:K00225] [EC:1.3.2.3]
            101249858  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
            101265133  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
            101247369  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
            101245594  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
            101250671  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
            101256973  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
            101251855  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
            101257677  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
            101266358  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
            101256763  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
            778288  MDHAR; monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
            101264360  AFRR; monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
            101253550  Monodehydroascorbate reductase (NADH)-like protein [KO:K08232] [EC:1.6.5.4]
            101263901  thylakoid lumenal 29 kDa protein, chloroplastic-like [KO:K00434] [EC:1.11.1.11]
            101264282  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            778224  APX2; cytosolic ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
            778341  APX6; thylakoid-bound ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
            101258987  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
            101264583  L-ascorbate peroxidase 5 [KO:K00434] [EC:1.11.1.11]
            101262528  APX7; stromal ascorbate peroxidase 7 [KO:K00434] [EC:1.11.1.11]
            101264261  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
            778223  APX1; cytosolic ascorbate peroxidase 1 [KO:K00434] [EC:1.11.1.11]
            101257790  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
            778229  DHAR1; dehydroascorbate reductase 1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            778343  DHAR2; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            101254215  uncharacterized protein LOC101254215 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            101254961  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            101263934  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            101251411  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            101258916  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
            101253411  L-ascorbate oxidase-like isoform X1 [KO:K00423] [EC:1.10.3.3]
            101266911  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            104645747  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            101247085  glutaredoxin-C3 [KO:K00128] [EC:1.2.1.3]
            101250104  ALDH2B7a; aldehyde dehydrogenase family 2 member B7a [KO:K00128] [EC:1.2.1.3]
            101262822  ALD3H1; aldehyde dehydrogenase family 3 member H2 [KO:K00128] [EC:1.2.1.3]
            101267634  ADH3F1a; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            101250474  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
            101254485  ADH2B7d; aldehyde dehydrogenase family 2 member B7d [KO:K00128] [EC:1.2.1.3]
            101257095  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
            112940646  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
            101252968  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
COMPOUND    C00022  Pyruvate
            C00026  2-Oxoglutarate
            C00029  UDP-glucose
            C00072  Ascorbate
            C00096  GDP-mannose
            C00137  myo-Inositol
            C00167  UDP-glucuronate
            C00191  D-Glucuronate
            C00216  D-Arabinose
            C00231  D-Xylulose 5-phosphate
            C00259  L-Arabinose
            C00333  D-Galacturonate
            C00433  2,5-Dioxopentanoate
            C00545  L-Arabinonate
            C00558  D-Tagaturonate
            C00617  UDP-D-galacturonate
            C00618  3-Dehydro-L-gulonate
            C00652  D-Arabinono-1,4-lactone
            C00679  5-Dehydro-4-deoxy-D-glucarate
            C00684  2-Dehydro-3-deoxy-L-arabinonate
            C00800  L-Gulonate
            C00818  D-Glucarate
            C00878  D-Arabinonate
            C00879  D-Galactarate
            C01040  L-Gulono-1,4-lactone
            C01041  Monodehydroascorbate
            C01101  L-Ribulose 5-phosphate
            C01114  L-Arabinono-1,4-lactone
            C01115  L-Galactono-1,4-lactone
            C01146  2-Hydroxy-3-oxopropanoate
            C01620  Threonate
            C01825  L-Galactose
            C02280  GDP-L-galactose
            C02670  D-Glucuronolactone
            C03033  beta-D-Glucuronoside
            C03064  3-Dehydro-L-threonate
            C03289  L-xylo-Hexulonolactone
            C03291  L-Xylulose 5-phosphate
            C03826  2-Dehydro-3-deoxy-D-xylonate
            C03921  2-Dehydro-3-deoxy-D-glucarate
            C04037  1-Phospho-alpha-D-galacturonate
            C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
            C05385  D-Glucuronate 1-phosphate
            C05411  L-Xylonate
            C05412  L-Lyxonate
            C05422  Dehydroascorbate
            C06316  Dehydro-D-arabinono-1,4-lactone
            C14899  3-Dehydro-L-gulonate 6-phosphate
            C15923  L-Gulose
            C15924  L-Gulose 1-phosphate
            C15925  GDP-L-gulose
            C15926  beta-L-Galactose 1-phosphate
            C15930  L-Galactonate
            C16186  L-Ascorbate 6-phosphate
            C20889  D-Galactaro-1,5-lactone
            C20896  D-Galactaro-1,4-lactone
            C21955  L-Galactono-1,5-lactone
REFERENCE   PMID:17222174
  AUTHORS   Linster CL, Van Schaftingen E
  TITLE     Vitamin C. Biosynthesis, recycling and degradation in mammals.
  JOURNAL   FEBS J 274:1-22 (2007)
            DOI:10.1111/j.1742-4658.2006.05607.x
REFERENCE   PMID:15564123
  AUTHORS   Valpuesta V, Botella MA.
  TITLE     Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  JOURNAL   Trends Plant Sci 9:573-7 (2004)
            DOI:10.1016/j.tplants.2004.10.002
REFERENCE   PMID:10517845
  AUTHORS   Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  TITLE     Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  JOURNAL   Plant Physiol 121:535-43 (1999)
            DOI:10.1104/pp.121.2.535
REFERENCE   PMID:16595667
  AUTHORS   Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  TITLE     Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  JOURNAL   J Biol Chem 281:15662-70 (2006)
            DOI:10.1074/jbc.M601409200
REFERENCE   PMID:17462988
  AUTHORS   Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  TITLE     Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  JOURNAL   J Biol Chem 282:18879-85 (2007)
            DOI:10.1074/jbc.M702094200
REFERENCE   PMID:14996803
  AUTHORS   Campos E, Baldoma L, Aguilar J, Badia J.
  TITLE     Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  JOURNAL   J Bacteriol 186:1720-8 (2004)
            DOI:10.1128/JB.186.6.1720-1728.2004
REFERENCE   PMID:12644495
  AUTHORS   Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  TITLE     The ascorbate transporter of Escherichia coli.
  JOURNAL   J Bacteriol 185:2243-50 (2003)
            DOI:10.1128/JB.185.7.2243-2250.2003
REL_PATHWAY sly00020  Citrate cycle (TCA cycle)
            sly00040  Pentose and glucuronate interconversions
            sly00051  Fructose and mannose metabolism
            sly00520  Amino sugar and nucleotide sugar metabolism
            sly00630  Glyoxylate and dicarboxylate metabolism
KO_PATHWAY  ko00053
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