ENTRY       sly00030                    Pathway
NAME        Pentose phosphate pathway - Solanum lycopersicum (tomato)
DESCRIPTION The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP sly00030  Pentose phosphate pathway
MODULE      sly_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:sly00030]
            sly_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sly00030]
            sly_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:sly00030]
            sly_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:sly00030]
DBLINKS     GO: 0006098
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101262594  GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
            543945  GPI1; glucose-6-phosphate isomerase 1 [KO:K01810] [EC:5.3.1.9]
            101258494  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101249507  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101253589  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101258470  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            101259276  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:3.1.1.31]
            101244165  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
            101264118  probable 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
            101263711  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
            101262229  probable 6-phosphogluconolactonase 4, chloroplastic isoform X2 [KO:K01057] [EC:3.1.1.31]
            101256373  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101263001  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101247915  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            101264109  ribulose-phosphate 3-epimerase, chloroplastic [KO:K01783] [EC:5.1.3.1]
            101262009  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:5.1.3.1]
            101251315  transketolase, chloroplastic-like [KO:K00615] [EC:2.2.1.1]
            101245299  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
            101265735  transketolase, chloroplastic-like [KO:K00615] [EC:2.2.1.1]
            543811  transaldolase ToTAL2 [KO:K00616] [EC:2.2.1.2]
            543623  TAL; transaldolase [KO:K00616] [EC:2.2.1.2]
            101264255  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
            101266787  probable ribose-5-phosphate isomerase 4, chloroplastic [KO:K01807] [EC:5.3.1.6]
            101260137  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
            101251203  uncharacterized protein LOC101251203 [KO:K00852] [EC:2.7.1.15]
            101267287  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
            101267885  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
            101263060  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
            101244195  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
            101262942  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
            101262732  ALDH11A3a; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
            101247372  gluconokinase isoform X2 [KO:K00851] [EC:2.7.1.12]
            101250853  FBA3; fructose-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
            101246870  FBA1; fructose-bisphosphate aldolase 1 [KO:K01623] [EC:4.1.2.13]
            101249787  FBA2; fructose-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
            101264821  fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:4.1.2.13]
            101243907  FBA6; fructose-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
            101262466  FBA8; fructose-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
            101266063  FBA7; fructose-1,6-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
            101253137  uncharacterized protein LOC101253137 [KO:K03841] [EC:3.1.3.11]
            101260852  fructose-1,6-bisphosphatase 1, chloroplastic [KO:K03841] [EC:3.1.3.11]
            101266629  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            101264273  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
            101262700  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            101266704  ATP-dependent 6-phosphofructokinase 4, chloroplastic isoform X1 [KO:K00850] [EC:2.7.1.11]
            101253771  ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
            101245938  ATP-dependent 6-phosphofructokinase 5, chloroplastic-like [KO:K00850] [EC:2.7.1.11]
            101268752  ATP-dependent 6-phosphofructokinase 6-like isoform X1 [KO:K00850] [EC:2.7.1.11]
            101268243  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
            101245480  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
            101259840  ATP-dependent 6-phosphofructokinase 6-like [KO:K00850] [EC:2.7.1.11]
            101268121  ATP-dependent 6-phosphofructokinase 6 isoform X1 [KO:K00850] [EC:2.7.1.11]
            101245455  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
            101246811  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha-like [KO:K00895] [EC:2.7.1.90]
            101243849  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:2.7.1.90]
            101245182  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:2.7.1.90]
COMPOUND    C00022  Pyruvate
            C00031  D-Glucose
            C00117  D-Ribose 5-phosphate
            C00118  D-Glyceraldehyde 3-phosphate
            C00119  5-Phospho-alpha-D-ribose 1-diphosphate
            C00121  D-Ribose
            C00197  3-Phospho-D-glycerate
            C00198  D-Glucono-1,5-lactone
            C00199  D-Ribulose 5-phosphate
            C00204  2-Dehydro-3-deoxy-D-gluconate
            C00221  beta-D-Glucose
            C00231  D-Xylulose 5-phosphate
            C00257  D-Gluconic acid
            C00258  D-Glycerate
            C00279  D-Erythrose 4-phosphate
            C00345  6-Phospho-D-gluconate
            C00577  D-Glyceraldehyde
            C00620  alpha-D-Ribose 1-phosphate
            C00631  2-Phospho-D-glycerate
            C00668  alpha-D-Glucose 6-phosphate
            C00672  2-Deoxy-D-ribose 1-phosphate
            C00673  2-Deoxy-D-ribose 5-phosphate
            C01151  D-Ribose 1,5-bisphosphate
            C01172  beta-D-Glucose 6-phosphate
            C01182  D-Ribulose 1,5-bisphosphate
            C01218  6-Phospho-2-dehydro-D-gluconate
            C01236  D-Glucono-1,5-lactone 6-phosphate
            C01801  Deoxyribose
            C03752  2-Amino-2-deoxy-D-gluconate
            C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
            C05345  beta-D-Fructose 6-phosphate
            C05378  beta-D-Fructose 1,6-bisphosphate
            C05382  Sedoheptulose 7-phosphate
            C06019  D-arabino-Hex-3-ulose 6-phosphate
            C06473  2-Keto-D-gluconic acid
            C20589  D-Glucosaminate-6-phosphate
REFERENCE   
  AUTHORS   Nishizuka Y (ed).
  TITLE     [Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1980)
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   
  AUTHORS   Michal G.
  TITLE     Biochemical Pathways
  JOURNAL   Wiley (1999)
REFERENCE   PMID:12700258
  AUTHORS   Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  TITLE     Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  JOURNAL   J Bacteriol 185:2793-801 (2003)
            DOI:10.1128/JB.185.9.2793-2801.2003
REFERENCE   PMID:16788179
  AUTHORS   Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  TITLE     The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  JOURNAL   J Bacteriol 188:4698-704 (2006)
            DOI:10.1128/JB.00492-06
REFERENCE   PMID:16428816
  AUTHORS   Kato N, Yurimoto H, Thauer RK
  TITLE     The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  JOURNAL   Biosci Biotechnol Biochem 70:10-21 (2006)
            DOI:10.1271/bbb.70.10
REFERENCE   PMID:23279921
  AUTHORS   Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  TITLE     Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  JOURNAL   FEBS J 280:1126-38 (2013)
            DOI:10.1111/febs.12106
REFERENCE   PMID:16458304
  AUTHORS   Reher M, Schonheit P
  TITLE     Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  JOURNAL   FEBS Lett 580:1198-204 (2006)
            DOI:10.1016/j.febslet.2006.01.029
REFERENCE   PMID:20023024
  AUTHORS   Reher M, Fuhrer T, Bott M, Schonheit P
  TITLE     The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  JOURNAL   J Bacteriol 192:964-74 (2010)
            DOI:10.1128/JB.01281-09
REL_PATHWAY sly00010  Glycolysis / Gluconeogenesis
            sly00040  Pentose and glucuronate interconversions
            sly00052  Galactose metabolism
            sly00230  Purine metabolism
            sly00240  Pyrimidine metabolism
            sly00340  Histidine metabolism
            sly00630  Glyoxylate and dicarboxylate metabolism
            sly00750  Vitamin B6 metabolism
KO_PATHWAY  ko00030
///
