ENTRY       sly00020                    Pathway
NAME        Citrate cycle (TCA cycle) - Solanum lycopersicum (tomato)
DESCRIPTION The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP sly00020  Citrate cycle (TCA cycle)
MODULE      sly_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sly00020]
            sly_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:sly00020]
            sly_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sly00020]
            sly_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:sly00020]
            sly_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sly00020]
DBLINKS     GO: 0006099
ORGANISM    Solanum lycopersicum (tomato) [GN:sly]
GENE        101249011  citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
            101260902  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
            101258079  citrate synthase 3, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
            101263147  ATP-citrate synthase beta chain protein 2-like [KO:K01648] [EC:2.3.3.8]
            101261460  ATP-citrate synthase alpha chain protein 3 [KO:K01648] [EC:2.3.3.8]
            101258745  ATP-citrate synthase alpha chain protein 2 isoform X3 [KO:K01648] [EC:2.3.3.8]
            101267503  ATP-citrate synthase beta chain protein 2 [KO:K01648] [EC:2.3.3.8]
            101246135  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
            101248455  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
            101254008  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
            101268602  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101255848  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            101248445  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
            101253647  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
            101251730  ICDH1; isocitrate dehydrogenase [NAD] regulatory subunit 1 [KO:K00030] [EC:1.1.1.41]
            101246168  3-isopropylmalate dehydrogenase, chloroplastic [KO:K00030] [EC:1.1.1.41]
            101246460  3-isopropylmalate dehydrogenase, chloroplastic isoform X1 [KO:K00030] [EC:1.1.1.41]
            101264112  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
            101259749  LOW QUALITY PROTEIN: 2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
            101258624  alpha-kGDH; alpha - ketoglutarate dehydrogenase subunit E2 [KO:K00658] [EC:2.3.1.61]
            101268590  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial [KO:K00658] [EC:2.3.1.61]
            101245293  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            101246429  dihydrolipoyl dehydrogenase 1, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
            101245444  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
            544237  dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
            543860  SCOA; succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
            543943  succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
            543863  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
            101256641  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial [KO:K00234] [EC:1.3.5.1]
            101253277  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
            101252979  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
            100736507  succinate dehydrogenase [KO:K00235] [EC:1.3.5.1]
            34678300  sdh3; succinate dehydrogenase subunit 3 [KO:K00236]
            34678270  sdh4; succinate dehydrogenase subunit 4 [KO:K25801]
            101265278  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
            101243791  fumarate hydratase 1, mitochondrial isoform X1 [KO:K01679] [EC:4.2.1.2]
            101253131  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
            778330  cMDH; cytosolic malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
            101249428  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
            101258932  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
            101258530  mMDH2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
            778285  mMDH1; mitochondrial malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
            778286  gMDH; glyoxisomal malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
            101248141  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
            101252671  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
            543812  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
            101258551  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
            101256654  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
            101256355  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
            543639  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
            101248181  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
            101254693  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
            101252977  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like isoform X1 [KO:K00162] [EC:1.2.4.1]
            101266731  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
            101268205  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
            101257033  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X2 [KO:K00627] [EC:2.3.1.12]
            101264480  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
            101257857  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
            101244498  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627] [EC:2.3.1.12]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00026  2-Oxoglutarate
            C00036  Oxaloacetate
            C00042  Succinate
            C00068  Thiamin diphosphate
            C00074  Phosphoenolpyruvate
            C00091  Succinyl-CoA
            C00122  Fumarate
            C00149  (S)-Malate
            C00158  Citrate
            C00311  Isocitrate
            C00417  cis-Aconitate
            C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
            C05379  Oxalosuccinate
            C05381  3-Carboxy-1-hydroxypropyl-ThPP
            C15972  Enzyme N6-(lipoyl)lysine
            C15973  Enzyme N6-(dihydrolipoyl)lysine
            C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
            C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
REFERENCE   
  AUTHORS   Nishizuka Y (ed).
  TITLE     [Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1980)
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   
  AUTHORS   Michal G.
  TITLE     Biochemical Pathways
  JOURNAL   Wiley (1999)
REL_PATHWAY sly00010  Glycolysis / Gluconeogenesis
            sly00053  Ascorbate and aldarate metabolism
            sly00061  Fatty acid biosynthesis
            sly00062  Fatty acid elongation
            sly00071  Fatty acid degradation
            sly00190  Oxidative phosphorylation
            sly00220  Arginine biosynthesis
            sly00250  Alanine, aspartate and glutamate metabolism
            sly00280  Valine, leucine and isoleucine degradation
            sly00350  Tyrosine metabolism
            sly00470  D-Amino acid metabolism
            sly00630  Glyoxylate and dicarboxylate metabolism
KO_PATHWAY  ko00020
///
