ENTRY       osa04145                    Pathway
NAME        Phagosome - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP osa04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4351534  syntaxin-81 isoform X1 [KO:K08492]
            4336482  syntaxin-81 [KO:K08492]
            4334384  25.3 kDa vesicle transport protein isoform X1 [KO:K08517]
            9271327  25.3 kDa vesicle transport protein [KO:K08517]
            9270655  25.3 kDa vesicle transport protein isoform X1 [KO:K08517]
            4352862  ras-related protein RABF2a [KO:K07889]
            4337982  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            4345232  phosphatidylinositol 3-kinase, root isoform isoform X1 [KO:K00914] [EC:2.7.1.137]
            4341751  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
            4328470  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
            4341339  V-type proton ATPase subunit B 1 isoform X1 [KO:K02147]
            4327833  V-type proton ATPase subunit B 2 isoform X1 [KO:K02147]
            4339800  V-type proton ATPase subunit C [KO:K02148]
            4337176  V-type proton ATPase subunit D [KO:K02149]
            4339122  V-type proton ATPase subunit E2 [KO:K02150]
            4326699  V-type proton ATPase subunit E [KO:K02150]
            4327166  V-type proton ATPase subunit E [KO:K02150]
            4331207  V-type proton ATPase subunit F [KO:K02151]
            4335014  V-type proton ATPase subunit F [KO:K02151]
            4336883  V-type proton ATPase subunit G1 [KO:K02152]
            4337284  V-type proton ATPase subunit e1 [KO:K02153]
            4327412  V-type proton ATPase subunit a1 [KO:K02154]
            4332270  V-type proton ATPase subunit a3 [KO:K02154]
            4348218  V-type proton ATPase subunit a3 [KO:K02154]
            4327660  probable V-type proton ATPase subunit d [KO:K02146]
            9272111  probable V-type proton ATPase subunit H [KO:K02144]
            4337563  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            4349890  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            4324550  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
            4329623  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            4351612  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
            4327731  V-type proton ATPase subunit c''2 [KO:K03661]
            4339322  ras-related protein Rab7 [KO:K07897]
            4325946  ras-related protein Rab7 [KO:K07897]
            4339450  ras-related protein Rab7 [KO:K07897]
            4327180  ras-related protein Rab7 [KO:K07897]
            4333966  tubulin alpha-1 chain [KO:K07374]
            4350197  tubulin alpha-2 chain [KO:K07374]
            4343694  tubulin alpha-1 chain [KO:K07374]
            4332083  tubulin alpha-2 chain [KO:K07374]
            4341810  tubulin beta-3 chain [KO:K07375]
            4334309  tubulin beta-7 chain [KO:K07375]
            4338790  tubulin beta-6 chain [KO:K07375]
            4327550  tubulin beta-4 chain [KO:K07375]
            4326917  tubulin beta-1 chain [KO:K07375]
            4328420  tubulin beta-5 chain [KO:K07375]
            4333632  tubulin beta-8 chain [KO:K07375]
            4331315  tubulin beta-2 chain [KO:K07375]
            4333051  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            4345628  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            9269751  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
            4337509  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            4344440  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            4345725  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            4347005  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            4340685  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            4346811  protein transport protein Sec61 subunit alpha [KO:K10956]
            4332042  protein transport protein Sec61 subunit alpha [KO:K10956]
            4345097  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            4346809  protein transport protein Sec61 subunit alpha [KO:K10956]
            4347548  protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
            107276128  protein transport protein Sec61 subunit alpha-like [KO:K10956]
            107276600  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
            4327929  protein transport protein Sec61 subunit beta [KO:K09481]
            9271333  protein transport protein Sec61 subunit beta [KO:K09481]
            9266625  protein transport protein Sec61 subunit beta [KO:K09481]
            9269540  protein transport protein Sec61 subunit beta [KO:K09481]
            4328492  protein transport protein Sec61 subunit gamma [KO:K07342]
            4341707  protein transport protein Sec61 subunit gamma-like [KO:K07342]
            4342826  calreticulin isoform X2 [KO:K08057]
            4334675  calreticulin-like [KO:K08057]
            4334509  calreticulin-2 [KO:K08057]
            4339262  calreticulin-3 [KO:K08057]
            9267167  calreticulin-3 [KO:K08057]
            4335732  calnexin homolog [KO:K08054]
            4325879  rac-like GTP-binding protein 1 [KO:K04392]
            4330693  rac-like GTP-binding protein 3 [KO:K04392]
            4340590  rac-like GTP-binding protein 4 [KO:K04392]
            4339304  rac-like GTP-binding protein 2 [KO:K04392]
            4329132  rac-like GTP-binding protein 7 [KO:K04392]
            4331272  rac-like GTP-binding protein 5 [KO:K04392]
            4328116  rac-like GTP-binding protein 6 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY osa04144  Endocytosis
KO_PATHWAY  ko04145
///
