ENTRY       osa04141                    Pathway
NAME        Protein processing in endoplasmic reticulum - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP osa04141  Protein processing in endoplasmic reticulum
DBLINKS     GO: 0030433 0034976
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4346811  protein transport protein Sec61 subunit alpha [KO:K10956]
            4332042  protein transport protein Sec61 subunit alpha [KO:K10956]
            4345097  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            4346809  protein transport protein Sec61 subunit alpha [KO:K10956]
            4347548  protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
            107276128  protein transport protein Sec61 subunit alpha-like [KO:K10956]
            107276600  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
            4327929  protein transport protein Sec61 subunit beta [KO:K09481]
            9271333  protein transport protein Sec61 subunit beta [KO:K09481]
            9266625  protein transport protein Sec61 subunit beta [KO:K09481]
            9269540  protein transport protein Sec61 subunit beta [KO:K09481]
            4328492  protein transport protein Sec61 subunit gamma [KO:K07342]
            4341707  protein transport protein Sec61 subunit gamma-like [KO:K07342]
            4329219  uncharacterized protein LOC4329219 [KO:K12275]
            4335435  dnaJ protein ERDJ2A [KO:K09540]
            4338348  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
            107275757  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
            4324876  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
            4335701  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
            4333265  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [KO:K12669]
            4342702  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
            4337389  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
            4339345  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
            4327748  alpha-glucosidase 2 isoform X1 [KO:K01228] [EC:3.2.1.106]
            4330492  heat shock 70 kDa protein 17 [KO:K09486]
            4328075  luminal-binding protein 3 [KO:K09490] [EC:3.6.4.10]
            4339788  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
            4338866  luminal-binding protein 2 [KO:K09490] [EC:3.6.4.10]
            4333877  luminal-binding protein 4 [KO:K09490] [EC:3.6.4.10]
            4340470  luminal-binding protein 4 [KO:K09490] [EC:3.6.4.10]
            9266859  uncharacterized protein LOC9266859 [KO:K09490] [EC:3.6.4.10]
            4344882  luminal-binding protein 2 [KO:K09490] [EC:3.6.4.10]
            4338568  luminal-binding protein 2 [KO:K09490] [EC:3.6.4.10]
            107275251  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
            4337860  dnaJ protein ERDJ3B [KO:K09517]
            4328607  dnaJ protein P58IPK homolog isoform X1 [KO:K09523]
            4327812  dnaJ protein P58IPK homolog [KO:K09523]
            4342077  endoplasmin homolog [KO:K09487]
            4345893  heat shock protein 90-5, chloroplastic [KO:K09487]
            4352339  heat shock protein 90-6, mitochondrial [KO:K09487]
            4347356  heat shock protein 90-5, chloroplastic [KO:K09487]
            4332068  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
            4324264  glucosidase 2 subunit beta [KO:K08288]
            4335732  calnexin homolog [KO:K08054]
            4342826  calreticulin isoform X2 [KO:K08057]
            4334675  calreticulin-like [KO:K08057]
            4334509  calreticulin-2 [KO:K08057]
            4339262  calreticulin-3 [KO:K08057]
            9267167  calreticulin-3 [KO:K08057]
            4336917  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
            4338088  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
            4350905  SEC12-like protein 2 [KO:K14003]
            4342601  SEC12-like protein 1 [KO:K14003]
            9270427  SEC12-like protein 1 isoform X1 [KO:K14003]
            4326797  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            4327708  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            4352510  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            4340541  GTP-binding protein SAR2 [KO:K07953] [EC:3.6.5.-]
            4328228  protein transport protein SEC13 homolog B [KO:K14004]
            4342827  protein transport protein SEC13 homolog B [KO:K14004]
            4334673  protein transport protein SEC13 homolog B [KO:K14004]
            4344154  protein transport protein SEC31 homolog B [KO:K14005]
            4345819  protein transport protein SEC23 [KO:K14006]
            4350403  protein transport protein SEC23 [KO:K14006]
            4334068  protein transport protein sec23-1 [KO:K14006]
            4347283  protein transport protein SEC23 [KO:K14006]
            4334998  protein transport protein Sec24-like At3g07100 [KO:K14007]
            4350517  protein transport protein Sec24-like CEF [KO:K14007]
            4352115  protein transport protein Sec24-like At4g32640 [KO:K14007]
            4330236  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
            4330685  probable alpha-mannosidase I MNS5 [KO:K10084]
            4327149  probable alpha-mannosidase I MNS4 isoform X1 [KO:K10085]
            4327971  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
            4329652  protein disulfide isomerase-like 1-3 [KO:K09580] [EC:5.3.4.1]
            4335906  protein disulfide isomerase-like 1-2 isoform X1 [KO:K09580] [EC:5.3.4.1]
            4350002  protein disulfide isomerase-like 1-1 [KO:K09580] [EC:5.3.4.1]
            4340223  protein disulfide isomerase-like 1-5 [KO:K09580] [EC:5.3.4.1]
            4329624  protein disulfide isomerase-like 5-3 [KO:K09580] [EC:5.3.4.1]
            4335881  protein disulfide isomerase-like 5-2 [KO:K09580] [EC:5.3.4.1]
            4347226  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
            4326806  protein disulfide isomerase-like 2-2 [KO:K09584] [EC:5.3.4.1]
            4337858  protein disulfide isomerase-like 2-1 isoform X2 [KO:K09584] [EC:5.3.4.1]
            4334011  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
            9268424  protein OS-9 homolog [KO:K10088]
            4342072  translocon-associated protein subunit alpha [KO:K13249]
            4326440  translocon-associated protein subunit beta [KO:K13250]
            4337538  translocon-associated protein subunit beta isoform X1 [KO:K13250]
            4329170  B-cell receptor-associated protein 31 [KO:K14009]
            4341009  uncharacterized protein LOC4341009 [KO:K14009]
            4338268  B-cell receptor-associated protein 31 [KO:K14009]
            4334781  B-cell receptor-associated protein 31 [KO:K14009]
            9270888  B-cell receptor-associated protein 31 [KO:K14009]
            4334809  derlin-2 [KO:K13989]
            4338013  derlin-1 [KO:K13989]
            4350306  plant UBX domain-containing protein 11 [KO:K24348]
            4347001  plant UBX domain-containing protein 2 [KO:K14011]
            4341597  plant UBX domain-containing protein 4 isoform X1 [KO:K14012]
            4336083  plant UBX domain-containing protein 4 [KO:K14012]
            4331645  cell division cycle protein 48 homolog [KO:K13525]
            4348731  cell division control protein 48 homolog E [KO:K13525]
            4325451  NPL4-like protein [KO:K14015]
            4328514  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            4336742  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            107276927  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            4339012  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
            4351208  heat shock cognate 70 kDa protein 2 [KO:K03283]
            4351875  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
            4327388  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
            4332413  heat shock cognate 70 kDa protein 2 [KO:K03283]
            4332420  heat shock cognate 70 kDa protein [KO:K03283]
            4334598  heat shock cognate 70 kDa protein 2 [KO:K03283]
            4332416  heat shock cognate 70 kDa protein [KO:K03283]
            9271426  heat shock cognate 70 kDa protein [KO:K03283]
            4349971  heat shock cognate 70 kDa protein [KO:K03283]
            4349972  heat shock cognate 70 kDa protein [KO:K03283]
            4338354  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
            107275844  heat shock cognate 70 kDa protein-like [KO:K03283]
            107279546  heat shock cognate 70 kDa protein-like [KO:K03283]
            4334359  dnaJ protein homolog [KO:K09503]
            4330201  dnaJ protein homolog 2 [KO:K09503]
            4333580  dnaJ protein homolog [KO:K09503]
            4336584  dnaJ protein homolog 2 [KO:K09503]
            4324566  chaperone protein dnaJ 49 [KO:K09518]
            4338551  chaperone protein dnaJ 49 [KO:K09518]
            4347402  heat shock protein 81-2 [KO:K04079]
            4345951  heat shock protein 81-1 [KO:K04079]
            4347405  heat shock protein 81-3 isoform X1 [KO:K04079]
            9267802  heat shock protein 81-3 [KO:K04079]
            9267997  heat shock protein 82 [KO:K04079]
            4334611  hsp70 nucleotide exchange factor fes1 isoform X1 [KO:K09562]
            4332391  uncharacterized protein LOC4332391 isoform X1 [KO:K09562]
            4347551  uncharacterized protein LOC4347551 [KO:K09562]
            4332360  17.4 kDa class I heat shock protein [KO:K13993]
            4328736  19.0 kDa class II heat shock protein [KO:K13993]
            4350180  21.9 kDa heat shock protein [KO:K13993]
            4325695  17.9 kDa heat shock protein 2 [KO:K13993]
            4335956  23.2 kDa heat shock protein [KO:K13993]
            4328171  18.9 kDa heat shock protein [KO:K13993]
            4330496  17.8 kDa heat shock protein [KO:K13993]
            4332237  26.7 kDa heat shock protein, chloroplastic [KO:K13993]
            4330933  18.6 kDa class III heat shock protein [KO:K13993]
            4343386  18.8 kDa class V heat shock protein [KO:K13993]
            4330786  24.1 kDa heat shock protein, mitochondrial [KO:K13993]
            4340508  26.2 kDa heat shock protein, mitochondrial [KO:K13993]
            4325698  16.9 kDa class I heat shock protein 2 [KO:K13993]
            4325697  16.9 kDa class I heat shock protein 1 [KO:K13993]
            4325696  16.9 kDa class I heat shock protein 3 [KO:K13993]
            4332361  18.1 kDa class I heat shock protein [KO:K13993]
            4332357  17.9 kDa class I heat shock protein [KO:K13993]
            4332363  17.7 kDa class I heat shock protein [KO:K13993]
            4325694  16.6 kDa heat shock protein [KO:K13993]
            4340661  16.0 kDa heat shock protein, peroxisomal [KO:K13993]
            107278626  23.6 kDa heat shock protein, mitochondrial [KO:K13993]
            4325342  18.0 kDa class II heat shock protein [KO:K13993]
            4328405  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
            4342300  phospholipase A-2-activating protein [KO:K14018]
            4328500  ubiquitin receptor RAD23b isoform X1 [KO:K10839]
            4345632  probable ubiquitin receptor RAD23 isoform X1 [KO:K10839]
            4347014  probable ubiquitin receptor RAD23 isoform X3 [KO:K10839]
            4340699  ubiquitin receptor RAD23d [KO:K10839]
            4349264  ubiquitin domain-containing protein DSK2a [KO:K04523]
            4331510  ubiquitin domain-containing protein DSK2a [KO:K04523]
            4343301  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
            4324808  putative ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
            4333165  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            4336257  probable serine/threonine-protein kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
            4332538  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
            4344379  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
            4340224  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
            4343198  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            9272448  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
            4341618  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
            4332614  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            4340379  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            4339013  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            4327386  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            4340826  ERAD-associated E3 ubiquitin-protein ligase HRD1 isoform X1 [KO:K10601] [EC:2.3.2.27]
            4325492  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            4333714  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            4352888  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            4344731  uncharacterized protein LOC4344731 [KO:K10666] [EC:2.3.2.27]
            4330106  E3 ubiquitin-protein ligase RMA1H1 isoform X1 [KO:K10666] [EC:2.3.2.27]
            4336483  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            4339072  uncharacterized protein LOC4339072 [KO:K10666] [EC:2.3.2.27]
            9270054  uncharacterized protein LOC9270054 [KO:K10666] [EC:2.3.2.27]
            4332310  ERAD-associated E3 ubiquitin-protein ligase component HRD3 [KO:K14026]
            4343241  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
            4337553  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
            4344499  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            4327450  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K06689] [EC:2.3.2.23]
            4337331  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
            4346639  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            4327162  ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
            4341133  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            4327451  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            4326152  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            4330476  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
            4325735  cullin-1 [KO:K03347]
            4337820  cullin-1 [KO:K03347]
            4325736  cullin-1 [KO:K03347]
            4347721  SKP1-like protein 1A [KO:K03094]
            4345419  SKP1-like protein 1A [KO:K03094]
            4346586  SKP1-like protein 1A [KO:K03094]
            4343963  SKP1-like protein 11 [KO:K03094]
            4346592  SKP1-like protein 4 [KO:K03094]
            4343000  SKP1-like protein 1B [KO:K03094]
            4348713  SKP1-like protein 11 [KO:K03094]
            4343962  SKP1-like protein 14 [KO:K03094]
            4339908  SKP1-like protein 13 [KO:K03094]
            4346585  probable disease resistance protein At1g61300 isoform X1 [KO:K03094]
            9270098  SKP1-like protein 1A [KO:K03094]
            107275366  SKP1-like protein 11 [KO:K03094]
            107275430  SKP1-like protein 1A [KO:K03094]
            107275462  SKP1-like protein 1B [KO:K03094]
            107275506  SKP1-like protein 1A [KO:K03094]
            107275529  SKP1-like protein 11 [KO:K03094]
            107275695  SKP1-like protein 1A [KO:K03094]
            107275970  SKP1-like protein 1A [KO:K03094]
            107276398  SKP1-like protein 11 [KO:K03094]
            107277355  SKP1-like protein 11 [KO:K03094]
            107278210  SKP1-like protein 13 [KO:K03094]
            107278737  SKP1-like protein 11 [KO:K03094]
            107281645  SKP1-like protein 11 [KO:K03094]
            107281670  SKP1-like protein 11 [KO:K03094]
            107282017  SKP1-like protein 1B [KO:K03094]
COMPOUND    C00076  Calcium cation
            G00009
            G00010
            G00011
            G00012
            G10694
REFERENCE   PMID:19491040
  AUTHORS   Naidoo N
  TITLE     ER and aging-Protein folding and the ER stress response.
  JOURNAL   Ageing Res Rev 8:150-9 (2009)
            DOI:10.1016/j.arr.2009.03.001
REFERENCE   PMID:18023214
  AUTHORS   Malhotra JD, Kaufman RJ
  TITLE     The endoplasmic reticulum and the unfolded protein response.
  JOURNAL   Semin Cell Dev Biol 18:716-31 (2007)
            DOI:10.1016/j.semcdb.2007.09.003
REFERENCE   PMID:20347046
  AUTHORS   Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  TITLE     Protein quality control in the ER: the recognition of misfolded proteins.
  JOURNAL   Semin Cell Dev Biol 21:500-11 (2010)
            DOI:10.1016/j.semcdb.2010.03.006
REFERENCE   PMID:20219571
  AUTHORS   Stolz A, Wolf DH
  TITLE     Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  JOURNAL   Biochim Biophys Acta 1803:694-705 (2010)
            DOI:10.1016/j.bbamcr.2010.02.005
REFERENCE   PMID:20112977
  AUTHORS   Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  TITLE     Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  JOURNAL   J Proteome Res 9:1763-71 (2010)
            DOI:10.1021/pr900900x
REL_PATHWAY osa00510  N-Glycan biosynthesis
            osa03050  Proteasome
            osa03060  Protein export
KO_PATHWAY  ko04141
///
