ENTRY       osa04136                    Pathway
NAME        Autophagy - other - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP osa04136  Autophagy - other
DBLINKS     GO: 0006914
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4351289  regulatory-associated protein of TOR 1 isoform X2 [KO:K07204]
            9266997  regulatory-associated protein of TOR 2 isoform X1 [KO:K07204]
            4338174  serine/threonine-protein kinase TOR [KO:K07203] [EC:2.7.11.1]
            4333729  protein LST8 homolog [KO:K08266]
            9268534  serine/threonine-protein kinase ATG1c isoform X1 [KO:K08269] [EC:2.7.11.1]
            9271984  autophagy-related protein 13a [KO:K08331]
            4336527  autophagy-related protein 13a [KO:K08331]
            9272454  autophagy-related protein 13b [KO:K08331]
            4352156  autophagy-related protein 101 isoform X1 [KO:K19730]
            4328503  autophagy-related protein 11 [KO:K08330]
            4351453  PP2A regulatory subunit TAP46 [KO:K17606]
            4349739  PP2A regulatory subunit TAP46 isoform X1 [KO:K17606]
            4341364  serine/threonine-protein phosphatase PP2A-1 catalytic subunit [KO:K04382] [EC:3.1.3.16]
            4328734  serine/threonine-protein phosphatase PP2A-3 catalytic subunit [KO:K04382] [EC:3.1.3.16]
            4331747  serine/threonine-protein phosphatase PP2A-4 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
            4334494  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
            4348601  serine/threonine-protein phosphatase PP2A-4 catalytic subunit [KO:K04382] [EC:3.1.3.16]
            4332250  autophagy-related protein 9 [KO:K17907]
            107275726  autophagy-related protein 9-like [KO:K17907]
            4340716  autophagy-related protein 2 [KO:K17906]
            4330978  autophagy-related protein 18b [KO:K17908]
            4333557  beclin-1-like protein [KO:K08334]
            4324394  beclin-1-like protein isoform X1 [KO:K08334]
            9271973  beclin-1-like protein [KO:K08334]
            4337982  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            4345232  phosphatidylinositol 3-kinase, root isoform isoform X1 [KO:K00914] [EC:2.7.1.137]
            4331010  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
            4340429  ubiquitin-like protein ATG12 [KO:K08336]
            4328092  autophagy protein 5 [KO:K08339]
            4334090  autophagy-related protein 16 [KO:K17890]
            4326644  ubiquitin-like modifier-activating enzyme atg7 isoform X1 [KO:K08337]
            9267420  ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
            9267916  ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
            4327346  autophagy-related protein 3 [KO:K08343]
            9270245  autophagy-related protein 3 isoform X1 [KO:K08343]
            4337052  autophagy-related protein 8B [KO:K08341]
            4343365  autophagy-related protein 8A [KO:K08341]
            4344857  autophagy-related protein 8C [KO:K08341]
            4349525  autophagy-related protein 8D isoform X2 [KO:K08341]
            107276566  autophagy-related protein 8D-like [KO:K08341]
            4337435  cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
            4333022  cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
COMPOUND    C00350  Phosphatidylethanolamine
            C01194  1-Phosphatidyl-D-myo-inositol
            C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:20962583
  AUTHORS   Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  TITLE     Autophagy in protists.
  JOURNAL   Autophagy 7:127-58 (2011)
            DOI:10.4161/auto.7.2.13310
REFERENCE   PMID:21660427
  AUTHORS   Avin-Wittenberg T, Honig A, Galili G
  TITLE     Variations on a theme: plant autophagy in comparison to yeast and mammals.
  JOURNAL   Protoplasma 249:285-99 (2012)
            DOI:10.1007/s00709-011-0296-z
REFERENCE   PMID:22242963
  AUTHORS   Liu Y, Bassham DC
  TITLE     Autophagy: pathways for self-eating in plant cells.
  JOURNAL   Annu Rev Plant Biol 63:215-37 (2012)
            DOI:10.1146/annurev-arplant-042811-105441
REFERENCE   PMID:22764279
  AUTHORS   Yoshimoto K
  TITLE     Beginning to understand autophagy, an intracellular self-degradation system in plants.
  JOURNAL   Plant Cell Physiol 53:1355-65 (2012)
            DOI:10.1093/pcp/pcs099
REFERENCE   PMID:24563201
  AUTHORS   Li F, Chung T, Vierstra RD
  TITLE     AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  JOURNAL   Plant Cell 26:788-807 (2014)
            DOI:10.1105/tpc.113.120014
REFERENCE   PMID:26598298
  AUTHORS   Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  TITLE     Autophagy in Plants--What's New on the Menu?
  JOURNAL   Trends Plant Sci 21:134-44 (2016)
            DOI:10.1016/j.tplants.2015.10.008
REFERENCE   PMID:26614870
  AUTHORS   Yang X, Bassham DC
  TITLE     New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  JOURNAL   Int Rev Cell Mol Biol 320:1-40 (2015)
            DOI:10.1016/bs.ircmb.2015.07.005
KO_PATHWAY  ko04136
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