ENTRY       osa03440                    Pathway
NAME        Homologous recombination - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP osa03440  Homologous recombination
DBLINKS     GO: 0000724
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4326564  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            4325041  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
            4333537  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
            4350329  protein RecA [KO:K03553]
            4337150  DNA polymerase I A, chloroplastic-like isoform X1 [KO:K02335] [EC:2.7.7.7]
            4344789  DNA polymerase I A, chloroplastic [KO:K02335] [EC:2.7.7.7]
            4330491  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:5.6.2.4]
            4329409  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
            4337137  double-strand break repair protein MRE11 [KO:K10865]
            4348951  nijmegen breakage syndrome 1 protein isoform X1 [KO:K10867]
            4326151  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
            4339293  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X1 [KO:K10683]
            4336384  BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
            107276010  BRCA1-associated RING domain protein 1-like [KO:K10683]
            4347791  Fanconi anemia group J protein homolog isoform X1 [KO:K15362] [EC:5.6.2.3]
            4332589  uncharacterized protein LOC4332589 [KO:K10728]
            4344363  LOW QUALITY PROTEIN: BRCT domain-containing protein At4g02110 [KO:K10728]
            4349978  DNA topoisomerase 2-binding protein 1-A isoform X1 [KO:K10728]
            4340143  uncharacterized protein LOC4340143 [KO:K20776]
            4342073  BRCA1-A complex subunit BRE [KO:K12173]
            4339481  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
            4324417  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B isoform X1 [KO:K08775]
            4325173  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
            4327264  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
            4337594  replication protein A 70 kDa DNA-binding subunit C [KO:K07466]
            4330902  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            4332052  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            4331236  replication protein A 32 kDa subunit A [KO:K10739]
            4330068  replication protein A 32 kDa subunit B isoform X2 [KO:K10739]
            4327706  replication protein A 14 kDa subunit [KO:K10740]
            4350923  DNA repair protein RAD51 homolog A [KO:K04482]
            4352257  DNA repair protein RAD51 homolog B [KO:K04482]
            4337655  DNA repair protein RAD51 homolog 2 [KO:K10869]
            4323853  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
            4346376  DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
            4329686  DNA repair protein XRCC3 homolog [KO:K10880]
            4330819  DNA repair and recombination protein RAD54 [KO:K10875] [EC:5.6.2.-]
            4338690  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
            4343066  protein CHROMATIN REMODELING 35 isoform X1 [KO:K10875] [EC:5.6.2.-]
            4340671  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            9267584  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            107277028  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
            4344376  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            107277180  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
            4349968  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            4331489  DNA polymerase delta small subunit [KO:K02328]
            4327080  protein IWS1 homolog A [KO:K03504]
            4347604  uncharacterized protein LOC4347604 [KO:K03505]
            4344737  DNA polymerase delta subunit 4 [KO:K03505]
            4330923  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:5.6.2.4]
            4335888  ATP-dependent DNA helicase Q-like 4A isoform X1 [KO:K10901] [EC:5.6.2.4]
            4347482  DNA topoisomerase 3-beta [KO:K03165] [EC:5.6.2.1]
            9269718  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
            4325837  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
            4337213  crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
REFERENCE   PMID:18086882
  AUTHORS   Maloisel L, Fabre F, Gangloff S.
  TITLE     DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  JOURNAL   Mol Cell Biol 28:1373-82 (2008)
            DOI:10.1128/MCB.01651-07
REFERENCE   PMID:17571595
  AUTHORS   Haruta-Takahashi N, Iwasaki H.
  TITLE     [Recombination mediators]
  JOURNAL   Seikagaku 79:449-53 (2007)
REFERENCE   PMID:18430459
  AUTHORS   Ouyang KJ, Woo LL, Ellis NA.
  TITLE     Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  JOURNAL   Mech Ageing Dev 129:425-40 (2008)
            DOI:10.1016/j.mad.2008.03.003
REFERENCE   PMID:15902993
  AUTHORS   Kawabata M, Kawabata T, Nishibori M.
  TITLE     Role of recA/RAD51 family proteins in mammals.
  JOURNAL   Acta Med Okayama 59:1-9 (2005)
            DOI:10.18926/AMO/31987
REFERENCE   PMID:12589470
  AUTHORS   Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  TITLE     Mitotic recombination in Saccharomyces cerevisiae.
  JOURNAL   Curr Genet 42:185-98 (2003)
            DOI:10.1007/s00294-002-0346-3
REFERENCE   PMID:16935872
  AUTHORS   Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  TITLE     Rad54: the Swiss Army knife of homologous recombination?
  JOURNAL   Nucleic Acids Res 34:4115-25 (2006)
            DOI:10.1093/nar/gkl481
REFERENCE   PMID:17395553
  AUTHORS   Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  TITLE     Recombination proteins and rescue of arrested replication forks.
  JOURNAL   DNA Repair (Amst) 6:967-80 (2007)
            DOI:10.1016/j.dnarep.2007.02.016
KO_PATHWAY  ko03440
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