ENTRY       osa03050                    Pathway
NAME        Proteasome - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP osa03050  Proteasome
DBLINKS     GO: 0000502
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4346252  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            4347735  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            4347083  26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
            4334802  26S proteasome non-ATPase regulatory subunit 12 homolog A isoform X1 [KO:K03035]
            4335951  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            4336206  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
            4329887  26S proteasome non-ATPase regulatory subunit 6-like [KO:K03037]
            4337291  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
            4332055  26S proteasome non-ATPase regulatory subunit 13 homolog B [KO:K03039]
            4324031  26S proteasome non-ATPase regulatory subunit 13 homolog B [KO:K03039]
            4338586  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            4324379  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            4341987  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            4343069  26S proteasome non-ATPase regulatory subunit 8 homolog A [KO:K03031]
            4325173  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
            4327264  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
            4332222  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
            4348083  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
            4328287  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            4341960  26S proteasome non-ATPase regulatory subunit 2 homolog A isoform X1 [KO:K03028]
            4346741  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            4344971  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            4336931  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            4339809  26S proteasome regulatory subunit RPN13 [KO:K06691]
            4340376  26S protease regulatory subunit 7 [KO:K03061]
            4330943  26S protease regulatory subunit 7 [KO:K03061]
            4344373  26S protease regulatory subunit 4 homolog [KO:K03062]
            4332553  26S protease regulatory subunit 4 homolog [KO:K03062]
            4328674  26S protease regulatory subunit 8 homolog A [KO:K03066]
            4341448  26S protease regulatory subunit 8 homolog A [KO:K03066]
            4341487  26S protease regulatory subunit S10B homolog B [KO:K03064]
            4328642  26S protease regulatory subunit S10B homolog B [KO:K03064]
            4340276  26S protease regulatory subunit 6A homolog [KO:K03065]
            4335380  26S protease regulatory subunit 6A homolog [KO:K03065]
            4331050  26S protease regulatory subunit 6A homolog [KO:K03065]
            4329182  26S protease regulatory subunit 6B homolog [KO:K03063]
            4347848  26S protease regulatory subunit 6B homolog [KO:K03063]
            4340828  proteasome activator subunit 4 isoform X1 [KO:K06699]
            4331828  proteasome subunit alpha type-6 isoform X2 [KO:K02730] [EC:3.4.25.1]
            4343891  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
            4330075  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
            4333000  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
            4340253  proteasome subunit alpha type-4-2 [KO:K02728] [EC:3.4.25.1]
            4340285  proteasome subunit alpha type-4-1 [KO:K02728] [EC:3.4.25.1]
            107278560  proteasome subunit alpha type-4-1 [KO:K02728] [EC:3.4.25.1]
            4347710  proteasome subunit alpha type-7-B [KO:K02731] [EC:3.4.25.1]
            4346245  proteasome subunit alpha type-7-A [KO:K02731] [EC:3.4.25.1]
            4350922  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
            4328215  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
            4339169  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
            4327357  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
            4340065  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
            4330861  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
            4338009  proteasome subunit beta type-7-A [KO:K02739] [EC:3.4.25.1]
            4341637  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
            4328517  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
            4333803  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
            4340166  proteasome subunit beta type-5-A [KO:K02737] [EC:3.4.25.1]
            4346117  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
            4347507  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
            4347573  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
            4343535  probable proteasome inhibitor isoform X1 [KO:K06700]
            4331035  cyclin-B1-2-like [KO:K11599]
            4346694  cyclin-B1-2-like [KO:K11599]
            4333335  cyclin-B1-2-like [KO:K11599]
REFERENCE   PMID:16338359
  AUTHORS   Hirano Y, Murata S, Tanaka K
  TITLE     Large- and small-scale purification of mammalian 26S proteasomes.
  JOURNAL   Methods Enzymol 399:227-40 (2005)
            DOI:10.1016/S0076-6879(05)99015-0
REFERENCE   PMID:18497808
  AUTHORS   Saeki Y, Tanaka K
  TITLE     Cell biology: two hands for degradation.
  JOURNAL   Nature 453:460-1 (2008)
            DOI:10.1038/453460a
REFERENCE   PMID:16919475
  AUTHORS   Smith DM, Benaroudj N, Goldberg A
  TITLE     Proteasomes and their associated ATPases: a destructive combination.
  JOURNAL   J Struct Biol 156:72-83 (2006)
            DOI:10.1016/j.jsb.2006.04.012
REFERENCE   PMID:16181324
  AUTHORS   Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  TITLE     Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  JOURNAL   Immunol Rev 207:19-30 (2005)
            DOI:10.1111/j.0105-2896.2005.00308.x
REFERENCE   PMID:19483713
  AUTHORS   Darwin KH
  TITLE     Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
  JOURNAL   Nat Rev Microbiol 7:485-91 (2009)
            DOI:10.1038/nrmicro2148
REFERENCE   PMID:23495936
  AUTHORS   Tomko RJ Jr, Hochstrasser M
  TITLE     Molecular architecture and assembly of the eukaryotic proteasome.
  JOURNAL   Annu Rev Biochem 82:415-45 (2013)
            DOI:10.1146/annurev-biochem-060410-150257
REFERENCE   PMID:28583440
  AUTHORS   Budenholzer L, Cheng CL, Li Y, Hochstrasser M
  TITLE     Proteasome Structure and Assembly.
  JOURNAL   J Mol Biol 429:3500-3524 (2017)
            DOI:10.1016/j.jmb.2017.05.027
REFERENCE   PMID:29071527
  AUTHORS   Cloos J, Roeten MS, Franke NE, van Meerloo J, Zweegman S, Kaspers GJ, Jansen G
  TITLE     (Immuno)proteasomes as therapeutic target in acute leukemia.
  JOURNAL   Cancer Metastasis Rev 36:599-615 (2017)
            DOI:10.1007/s10555-017-9699-4
REFERENCE   PMID:22215586
  AUTHORS   Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  TITLE     Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
  JOURNAL   Proc Natl Acad Sci U S A 109:1479-84 (2012)
            DOI:10.1073/pnas.1119394109
REL_PATHWAY osa04120  Ubiquitin mediated proteolysis
KO_PATHWAY  ko03050
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