ENTRY       osa03013                    Pathway
NAME        Nucleocytoplasmic transport - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP osa03013  Nucleocytoplasmic transport
DBLINKS     GO: 0050658
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4349688  aladin [KO:K14320]
            4351405  aladin [KO:K14320]
            4341994  zinc finger CCCH domain-containing protein 46 [KO:K14321]
            4329863  protein GLE1 isoform X1 [KO:K18723]
            4331680  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            4326570  protein RAE1 [KO:K14298]
            4344798  protein RAE1 [KO:K14298]
            4351598  nuclear pore complex protein NUP98A [KO:K14297]
            4351597  nuclear pore complex protein NUP98A [KO:K14297]
            4325429  nuclear pore complex protein NUP98A [KO:K14297]
            4331780  nuclear pore complex protein NUP96 [KO:K14297]
            4344328  nuclear pore complex protein NUP214 [KO:K14317]
            4336930  nuclear pore complex protein NUP88 [KO:K14318]
            4339487  RAN GTPase-activating protein 1 [KO:K14319]
            4331446  SUMO-conjugating enzyme SCE1 [KO:K10577]
            4349236  SUMO-conjugating enzyme SCE1 [KO:K10577]
            4336760  SUMO-conjugating enzyme SCE1 [KO:K10577]
            9266752  nuclear pore complex protein NUP160 isoform X1 [KO:K14303]
            4326176  nuclear pore complex protein NUP85 [KO:K14304]
            4328228  protein transport protein SEC13 homolog B [KO:K14004]
            4342827  protein transport protein SEC13 homolog B [KO:K14004]
            4334673  protein transport protein SEC13 homolog B [KO:K14004]
            4351012  nuclear pore complex protein NUP107 [KO:K14301]
            4332118  nuclear pore complex protein NUP133 [KO:K14300]
            4326622  protein SEH1 [KO:K14299]
            4324750  nuclear pore complex protein NUP62 [KO:K14306]
            4347240  nuclear pore complex protein NUP58 [KO:K14307]
            9267365  nuclear pore complex protein NUP58 isoform X1 [KO:K14307]
            4342961  nuclear pore complex protein NUP54 [KO:K14308]
            4328655  nuclear pore complex protein NUP205 [KO:K14310]
            9269589  uncharacterized protein LOC9269589 [KO:K14311]
            4340842  nuclear pore complex protein NUP155 [KO:K14312]
            4332834  nuclear pore complex protein NUP93A [KO:K14309]
            4327063  nuclear pore complex protein NUP35 [KO:K14313]
            4339346  nuclear pore complex protein NUP35 [KO:K14313]
            4330343  uncharacterized protein LOC4330343 [KO:K14315]
            4347873  nuclear pore complex protein GP210 isoform X1 [KO:K14314]
            4326558  uncharacterized protein LOC4326558 [KO:K20724]
            4324102  uncharacterized protein LOC4324102 [KO:K20724]
            4339776  transmembrane protein 33 homolog [KO:K20724]
            4330687  nuclear-pore anchor isoform X1 [KO:K09291]
            4337853  importin subunit alpha-1b [KO:K15042]
            4324088  importin subunit alpha-2 [KO:K15042]
            4344355  importin subunit alpha-1a-like isoform X1 [KO:K15042]
            4326488  importin subunit alpha-1b-like isoform X1 [KO:K15042]
            4352566  importin subunit beta-1 [KO:K14293]
            4338508  importin subunit beta-1 [KO:K14293]
            4332526  importin subunit beta-1 [KO:K14293]
            4337505  transportin-1 [KO:K18752]
            9270745  transportin-3 [KO:K15436]
            4350677  uncharacterized protein LOC4350677 [KO:K15436]
            9269497  importin-4 isoform X1 [KO:K20221]
            4343696  importin-5 [KO:K20222]
            4333825  importin-5 [KO:K20222]
            4329353  importin beta-like SAD2 [KO:K20223]
            4335508  importin beta-like SAD2 isoform X1 [KO:K20223]
            4340740  importin-9 [KO:K20224]
            4344385  importin-11 [KO:K25201]
            4326461  snurportin-1 [KO:K13151]
            4334849  protein EXPORTIN 1A isoform X1 [KO:K14290]
            4327779  exportin-2 [KO:K18423]
            4343885  exportin-T [KO:K14288]
            4348897  exportin-4 isoform X1 [KO:K25203]
            4325820  protein HASTY 1 isoform X1 [KO:K14289]
            4333453  exportin-7-A isoform X1 [KO:K18460]
            4324273  exportin-7 isoform X1 [KO:K18460]
            4339683  GTP-binding nuclear protein Ran-2 [KO:K07936]
            4325312  GTP-binding nuclear protein Ran-1 [KO:K07936]
            9266942  GTP-binding nuclear protein Ran-3 [KO:K07936]
            4331810  elongation factor 1-alpha [KO:K03231]
            4331811  elongation factor 1-alpha [KO:K03231]
            4331812  elongation factor 1-alpha [KO:K03231]
            4331813  elongation factor 1-alpha [KO:K03231]
            4324680  uncharacterized protein LOC4324680 [KO:K14291]
            4332822  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
            4329963  nuclear cap-binding protein subunit 2 [KO:K12883]
            4349477  60S ribosomal export protein NMD3 [KO:K07562]
            4337757  RNA-binding protein 8A [KO:K12876]
            4334528  RNA-binding protein 8A [KO:K12876]
            4351998  protein mago nashi homolog [KO:K12877]
            4344462  protein mago nashi homolog isoform X2 [KO:K12877]
            4326580  DEAD-box ATP-dependent RNA helicase 2 [KO:K13025] [EC:3.6.4.13]
            4333273  DEAD-box ATP-dependent RNA helicase 34 [KO:K13025] [EC:3.6.4.13]
            4343967  protein starmaker isoform X1 [KO:K12875]
            4332988  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
            4328127  histone deacetylase complex subunit SAP18 [KO:K14324]
            4325394  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
            4337561  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
            4333834  pinin [KO:K13114]
            4332426  THO complex subunit 4A [KO:K12881]
            4349526  THO complex subunit 4A isoform X1 [KO:K12881]
            4342793  THO complex subunit 4A isoform X1 [KO:K12881]
            4340675  THO complex subunit 4D [KO:K12881]
            4345621  THO complex subunit 4D isoform X1 [KO:K12881]
            4351236  THO complex subunit 4A isoform X1 [KO:K12881]
            4343292  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:3.6.4.13 5.6.2.3]
            4330058  regulator of nonsense transcripts UPF2 [KO:K14327]
            4335928  regulator of nonsense transcripts UPF3 isoform X1 [KO:K14328]
            4326193  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:3.6.4.13]
            4326192  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:3.6.4.13]
            4332383  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
            4332324  partner of Y14 and mago isoform X1 [KO:K14294]
            4331353  THO complex subunit 1 [KO:K12878]
            4324336  THO complex subunit 2 isoform X1 [KO:K12879]
            4330841  THO complex subunit 5A [KO:K13174]
            4346861  THO complex subunit 6 [KO:K13175]
            4344717  THO complex subunit 7B isoform X1 [KO:K13176]
            4339657  THO complex subunit 7A [KO:K13176]
            4346657  THO complex subunit 3 [KO:K12880]
REFERENCE   PMID:16777596
  AUTHORS   Tran EJ, Wente SR
  TITLE     Dynamic nuclear pore complexes: life on the edge.
  JOURNAL   Cell 125:1041-53 (2006)
            DOI:10.1016/j.cell.2006.05.027
REFERENCE   PMID:15519698
  AUTHORS   Rodriguez MS, Dargemont C, Stutz F
  TITLE     Nuclear export of RNA.
  JOURNAL   Biol Cell 96:639-55 (2004)
            DOI:10.1016/j.biolcel.2004.04.014
REFERENCE   PMID:18313922
  AUTHORS   Palancade B, Doye V
  TITLE     Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  JOURNAL   Trends Cell Biol 18:174-83 (2008)
            DOI:10.1016/j.tcb.2008.02.001
REFERENCE   PMID:15901496
  AUTHORS   Reed R, Cheng H
  TITLE     TREX, SR proteins and export of mRNA.
  JOURNAL   Curr Opin Cell Biol 17:269-73 (2005)
            DOI:10.1016/j.ceb.2005.04.011
REFERENCE   PMID:16314458
  AUTHORS   Tange TO, Shibuya T, Jurica MS, Moore MJ
  TITLE     Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  JOURNAL   RNA 11:1869-83 (2005)
            DOI:10.1261/rna.2155905
REFERENCE   PMID:28673770
  AUTHORS   Beck M, Schirmacher P, Singer S
  TITLE     Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  JOURNAL   J Hepatol 67:1051-1061 (2017)
            DOI:10.1016/j.jhep.2017.06.021
REL_PATHWAY osa03015  mRNA surveillance pathway
KO_PATHWAY  ko03013
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