ENTRY       osa01210                    Pathway
NAME        2-Oxocarboxylic acid metabolism - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION 2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
PATHWAY_MAP osa01210  2-Oxocarboxylic acid metabolism
MODULE      osa_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:osa01210]
            osa_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:osa01210]
            osa_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:osa01210]
            osa_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:osa01210]
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
REL_PATHWAY osa00020  Citrate cycle (TCA cycle)
            osa00220  Arginine biosynthesis
            osa00260  Glycine, serine and threonine metabolism
            osa00290  Valine, leucine and isoleucine biosynthesis
            osa00300  Lysine biosynthesis
            osa00966  Glucosinolate biosynthesis
KO_PATHWAY  ko01210
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