ENTRY       osa00908                    Pathway
NAME        Zeatin biosynthesis - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
CLASS       Metabolism; Metabolism of terpenoids and polyketides
PATHWAY_MAP osa00908  Zeatin biosynthesis
DBLINKS     GO: 0009691
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4334529  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            4339535  adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            4332870  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            107276332  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            107277295  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            107278247  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            107275347  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            107275425  adenylate isopentenyltransferase 8, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
            9269428  cytokinin hydroxylase [KO:K10717]
            107275990  cytokinin hydroxylase-like [KO:K10717]
            4338605  cytokinin dehydrogenase 9 [KO:K00279] [EC:1.5.99.12]
            4327887  cytokinin dehydrogenase 5 isoform X1 [KO:K00279] [EC:1.5.99.12]
            4326515  cytokinin dehydrogenase 4 [KO:K00279] [EC:1.5.99.12]
            4348932  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
            4325668  cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
            107275724  cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
            107275892  cytokinin dehydrogenase 6 [KO:K00279] [EC:1.5.99.12]
            107276418  cytokinin dehydrogenase 10 [KO:K00279] [EC:1.5.99.12]
            4327333  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
            4345764  cytokinin dehydrogenase 11 [KO:K00279] [EC:1.5.99.12]
            107275925  cytokinin dehydrogenase 8 isoform X2 [KO:K00279] [EC:1.5.99.12]
            4332879  UDP-glycosyltransferase 73C5 [KO:K13496] [EC:2.4.1.-]
            4348200  UDP-glycosyltransferase 73C1 [KO:K13496] [EC:2.4.1.-]
            4342142  tRNA dimethylallyltransferase 9 [KO:K00791] [EC:2.5.1.75]
            4336629  cis-zeatin O-glucosyltransferase 1 [KO:K13495] [EC:2.4.1.215]
            4336630  cis-zeatin O-glucosyltransferase 1 [KO:K13495] [EC:2.4.1.215]
            4336683  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
            4336681  cis-zeatin O-glucosyltransferase 1 [KO:K13495] [EC:2.4.1.215]
COMPOUND    C00002  ATP
            C00008  ADP
            C00015  UDP
            C00019  S-Adenosyl-L-methionine
            C00020  AMP
            C00029  UDP-glucose
            C00033  Acetate
            C00147  Adenine
            C00170  5'-Methylthioadenosine
            C00190  UDP-D-xylose
            C00235  Dimethylallyl diphosphate
            C00371  Zeatin
            C00979  O-Acetyl-L-serine
            C01513  Lupinate
            C01804  Discadenine
            C02029  Dihydrozeatin
            C03300  O-beta-D-Xylosylzeatin
            C03423  O-beta-D-Glucosylzeatin
            C04083  N6-(Delta2-Isopentenyl)-adenine
            C04432  tRNA containing 6-isopentenyladenosine
            C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
            C07330  3-Methyl-2-butenal
            C15545  cis-Zeatin
            C15546  O-beta-D-Glucopyranosyl-cis-zeatin
            C16424  Isopentenyladenosine-5'-triphosphate
            C16426  Isopentenyladenosine-5'-diphosphate
            C16427  Isopentenyl adenosine
            C16428  trans-Zeatin riboside triphosphate
            C16429  trans-Zeatin riboside diphosphate
            C16430  trans-Zeatin riboside monophosphate
            C16431  trans-Zeatin riboside
            C16441  cis-Zeatin riboside monophosphate
            C16443  trans-Zeatin-7-beta-D-glucoside
            C16445  Dihydrozeatin riboside monophosphate
            C16447  Dihydrozeatin riboside
            C16448  Dihydrozeatin-O-glucoside
            C16449  cis-Zeatin riboside
            C16467  cis-Prenyl-tRNA
            C17324  tRNA adenine
REFERENCE   PMID:14726522
  AUTHORS   Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  TITLE     Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  JOURNAL   J Biol Chem 279:14049-54 (2004)
            DOI:10.1074/jbc.M314195200
REFERENCE   PMID:11313355
  AUTHORS   Takei K, Sakakibara H, Sugiyama T.
  TITLE     Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  JOURNAL   J Biol Chem 276:26405-10 (2001)
            DOI:10.1074/jbc.M102130200
REFERENCE   PMID:11479373
  AUTHORS   Kakimoto T.
  TITLE     Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  JOURNAL   Plant Cell Physiol 42:677-85 (2001)
            DOI:10.1093/pcp/pce112
REFERENCE   PMID:15280363
  AUTHORS   Takei K, Yamaya T, Sakakibara H.
  TITLE     Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  JOURNAL   J Biol Chem 279:41866-72 (2004)
            DOI:10.1074/jbc.M406337200
REFERENCE   PMID:15342621
  AUTHORS   Hou B, Lim EK, Higgins GS, Bowles DJ.
  TITLE     N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  JOURNAL   J Biol Chem 279:47822-32 (2004)
            DOI:10.1074/jbc.M409569200
REFERENCE   PMID:9874810
  AUTHORS   Martin RC, Mok MC, Mok DW
  TITLE     Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  JOURNAL   Proc Natl Acad Sci U S A 96:284-9 (1999)
            DOI:10.1073/pnas.96.1.284
REFERENCE   PMID:10364407
  AUTHORS   Martin RC, Mok MC, Mok DW
  TITLE     A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  JOURNAL   Plant Physiol 120:553-8 (1999)
            DOI:10.1104/pp.120.2.553
REFERENCE   PMID:12644686
  AUTHORS   Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  TITLE     O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  JOURNAL   Plant Physiol 131:1374-80 (2003)
            DOI:10.1104/pp.017210
REFERENCE   PMID:14555694
  AUTHORS   Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  TITLE     Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  JOURNAL   Plant Cell 15:2532-50 (2003)
            DOI:10.1105/tpc.014928
REFERENCE   PMID:17062755
  AUTHORS   Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  TITLE     Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  JOURNAL   Proc Natl Acad Sci U S A 103:16598-603 (2006)
            DOI:10.1073/pnas.0603522103
REL_PATHWAY osa00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko00908
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