ENTRY       osa00480                    Pathway
NAME        Glutathione metabolism - Oryza sativa japonica (Japanese rice) (RefSeq)
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP osa00480  Glutathione metabolism
MODULE      osa_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:osa00480]
DBLINKS     GO: 0006749
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4324525  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            4324526  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            4336033  gamma-glutamyltranspeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            4329321  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
            4335982  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
            9270353  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
            4337696  glutamate--cysteine ligase A, chloroplastic [KO:K01919] [EC:6.3.2.2]
            4343165  glutamate--cysteine ligase B, chloroplastic [KO:K01919] [EC:6.3.2.2]
            9272324  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
            4351008  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
            4352123  putative leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
            4346337  puromycin-sensitive aminopeptidase isoform X2 [KO:K01256] [EC:3.4.11.2]
            4349207  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4343183  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
            4333870  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            4332456  protein IN2-1 homolog A [KO:K00799] [EC:2.5.1.18]
            4326828  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            4349192  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4325707  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            9269614  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4347319  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            4325704  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
            4325710  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            4325715  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            4331535  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
            4332455  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
            4337813  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            4350808  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            4325763  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4325764  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4325766  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4346877  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
            4349185  uncharacterized protein LOC4349185 [KO:K00799] [EC:2.5.1.18]
            4349188  uncharacterized protein LOC4349188 [KO:K00799] [EC:2.5.1.18]
            4349190  uncharacterized protein LOC4349190 [KO:K00799] [EC:2.5.1.18]
            4349191  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349198  glutathione S-transferase L2, chloroplastic [KO:K00799] [EC:2.5.1.18]
            4349202  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349203  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4334347  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
            4333555  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
            4326887  probable glutathione S-transferase GSTF2 [KO:K00799] [EC:2.5.1.18]
            4324574  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4325437  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
            4325709  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            4325712  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
            4325765  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4325768  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            4326483  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
            4331532  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
            4331533  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
            4331534  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
            4342499  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4348461  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4348549  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
            4348924  glutathione S-transferase U17 isoform X1 [KO:K00799] [EC:2.5.1.18]
            4349181  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349196  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349197  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349200  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349201  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349204  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349205  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349210  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4349270  glutathione S-transferase APIC [KO:K00799] [EC:2.5.1.18]
            9268428  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4325642  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4325643  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            4333371  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            4338787  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            4349167  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
            4342418  LOW QUALITY PROTEIN: glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            4337622  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            4340581  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            4331112  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
            4331719  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
            4348623  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
            4336353  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            4339674  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            4327213  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            4324176  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            4339892  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            4350528  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            4342988  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            4336209  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            4329889  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            4332659  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            4333103  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            4336627  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            4340341  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            4330235  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            4332876  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
            4350287  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
            4344045  1-Cys peroxiredoxin A [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
            4344046  1-Cys peroxiredoxin B [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
            4347746  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            4342996  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
            4341195  spermine synthase [KO:K00797] [EC:2.5.1.16]
            4328910  spermine synthase [KO:K00797] [EC:2.5.1.16]
            4346247  probable L-ascorbate peroxidase 4 [KO:K00434] [EC:1.11.1.11]
            4344397  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
            4335202  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            4336886  thylakoid lumenal 29 kDa protein, chloroplastic [KO:K00434] [EC:1.11.1.11]
            4332474  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            4329643  probable L-ascorbate peroxidase 8, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
            4335896  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
            4351663  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
            4351664  probable L-ascorbate peroxidase 5, chloroplastic isoform X2 [KO:K00434] [EC:1.11.1.11]
            4346078  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
            9269342  probable L-ascorbate peroxidase 4 [KO:K00434] [EC:1.11.1.11]
            4340258  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
            4331059  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
            4339981  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
            9266846  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
COMPOUND    C00005  NADPH
            C00006  NADP+
            C00024  Acetyl-CoA
            C00025  L-Glutamate
            C00037  Glycine
            C00051  Glutathione
            C00072  Ascorbate
            C00077  L-Ornithine
            C00097  L-Cysteine
            C00127  Glutathione disulfide
            C00134  Putrescine
            C00151  L-Amino acid
            C00315  Spermidine
            C00669  gamma-L-Glutamyl-L-cysteine
            C00750  Spermine
            C01322  RX
            C01419  Cys-Gly
            C01672  Cadaverine
            C01879  5-Oxoproline
            C02090  Trypanothione
            C02320  R-S-Glutathione
            C03170  Trypanothione disulfide
            C03646  Bis-gamma-glutamylcystine
            C03740  (5-L-Glutamyl)-L-amino acid
            C05422  Dehydroascorbate
            C05726  S-Substituted L-cysteine
            C05727  S-Substituted N-acetyl-L-cysteine
            C05729  R-S-Cysteinylglycine
            C05730  Glutathionylspermidine
            C16562  Glutathionylspermine
            C16563  Bis(glutathionyl)spermine
            C16564  Bis(glutathionyl)spermine disulfide
            C16565  Aminopropylcadaverine
            C16566  Glutathionylaminopropylcadaverine
            C16567  Homotrypanothione
            C16568  Homotrypanothione disulfide
            C16663  Tryparedoxin
            C16664  Tryparedoxin disulfide
REFERENCE   PMID:12675513
  AUTHORS   Josch C, Klotz LO, Sies H.
  TITLE     Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  JOURNAL   Biol Chem 384:213-8 (2003)
            DOI:10.1515/BC.2003.023
REFERENCE   PMID:18482986
  AUTHORS   Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  TITLE     A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  JOURNAL   J Biol Chem 283:19351-8 (2008)
            DOI:10.1074/jbc.M801034200
REFERENCE   PMID:14583094
  AUTHORS   Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  TITLE     New role for leucyl aminopeptidase in glutathione turnover.
  JOURNAL   Biochem J 378:35-44 (2004)
            DOI:10.1042/BJ20031336
REFERENCE   PMID:11157967
  AUTHORS   Suzuki H, Kamatani S, Kim ES, Kumagai H.
  TITLE     Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  JOURNAL   J Bacteriol 183:1489-90 (2001)
            DOI:10.1128/JB.183.4.1489-1490.2001
REFERENCE   PMID:15610825
  AUTHORS   Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  TITLE     Trypanothione biosynthesis in Leishmania major.
  JOURNAL   Mol Biochem Parasitol 139:107-16 (2005)
            DOI:10.1016/j.molbiopara.2004.10.004
REFERENCE   PMID:12049631
  AUTHORS   Oza SL, Ariyanayagam MR, Fairlamb AH.
  TITLE     Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  JOURNAL   Biochem J 364:679-86 (2002)
            DOI:10.1042/BJ20011370
REFERENCE   PMID:9677355
  AUTHORS   Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  TITLE     Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  JOURNAL   J Biol Chem 273:19383-90 (1998)
            DOI:10.1074/jbc.273.31.19383
REFERENCE   PMID:12750367
  AUTHORS   Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  TITLE     Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 278:27612-9 (2003)
            DOI:10.1074/jbc.M302750200
REFERENCE   PMID:12967709
  AUTHORS   Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  TITLE     Properties of trypanothione synthetase from Trypanosoma brucei.
  JOURNAL   Mol Biochem Parasitol 131:25-33 (2003)
            DOI:10.1016/S0166-6851(03)00176-2
REFERENCE   PMID:12121990
  AUTHORS   Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  TITLE     A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 277:35853-61 (2002)
            DOI:10.1074/jbc.M204403200
REFERENCE   PMID:15537651
  AUTHORS   Comini M, Menge U, Wissing J, Flohe L.
  TITLE     Trypanothione synthesis in crithidia revisited.
  JOURNAL   J Biol Chem 280:6850-60 (2005)
            DOI:10.1074/jbc.M404486200
REFERENCE   PMID:7813456
  AUTHORS   Hunter KJ, Le Quesne SA, Fairlamb AH.
  TITLE     Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  JOURNAL   Eur J Biochem 226:1019-27 (1994)
            DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
REFERENCE   PMID:12751784
  AUTHORS   Krauth-Siegel RL, Meiering SK, Schmidt H.
  TITLE     The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  JOURNAL   Biol Chem 384:539-49 (2003)
            DOI:10.1515/BC.2003.062
REFERENCE   PMID:18395526
  AUTHORS   Krauth-Siegel RL, Comini MA.
  TITLE     Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  JOURNAL   Biochim Biophys Acta 1780:1236-48 (2008)
            DOI:10.1016/j.bbagen.2008.03.006
REFERENCE   PMID:8892297
  AUTHORS   Krauth-Siegel RL, Ludemann H.
  TITLE     Reduction of dehydroascorbate by trypanothione.
  JOURNAL   Mol Biochem Parasitol 80:203-8 (1996)
            DOI:10.1016/0166-6851(96)02689-8
REFERENCE   PMID:11150302
  AUTHORS   Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  TITLE     Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  JOURNAL   J Biol Chem 276:10602-6 (2001)
            DOI:10.1074/jbc.M010352200
REFERENCE   PMID:12949079
  AUTHORS   Schmidt H, Krauth-Siegel RL.
  TITLE     Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  JOURNAL   J Biol Chem 278:46329-36 (2003)
            DOI:10.1074/jbc.M305338200
REFERENCE   PMID:9851611
  AUTHORS   Tetaud E, Fairlamb AH.
  TITLE     Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  JOURNAL   Mol Biochem Parasitol 96:111-23 (1998)
            DOI:10.1016/S0166-6851(98)00120-0
REFERENCE   PMID:12446213
  AUTHORS   Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  TITLE     Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  JOURNAL   Free Radic Biol Med 33:1552-62 (2002)
            DOI:10.1016/S0891-5849(02)01089-4
REFERENCE   PMID:10713147
  AUTHORS   Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  TITLE     Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 275:8220-5 (2000)
            DOI:10.1074/jbc.275.11.8220
REFERENCE   PMID:17922848
  AUTHORS   Konig J, Fairlamb AH.
  TITLE     A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  JOURNAL   FEBS J 274:5643-58 (2007)
            DOI:10.1111/j.1742-4658.2007.06087.x
REFERENCE   PMID:12466271
  AUTHORS   Hillebrand H, Schmidt A, Krauth-Siegel RL.
  TITLE     A second class of peroxidases linked to the trypanothione metabolism.
  JOURNAL   J Biol Chem 278:6809-15 (2003)
            DOI:10.1074/jbc.M210392200
REFERENCE   PMID:14982633
  AUTHORS   Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  TITLE     Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  JOURNAL   Mol Microbiol 51:1401-12 (2004)
            DOI:10.1046/j.1365-2958.2003.03913.x
REFERENCE   PMID:6798961
  AUTHORS   Pegg AE, Shuttleworth K, Hibasami H.
  TITLE     Specificity of mammalian spermidine synthase and spermine synthase.
  JOURNAL   Biochem J 197:315-20 (1981)
            DOI:10.1042/bj1970315
REL_PATHWAY osa00220  Arginine biosynthesis
            osa00250  Alanine, aspartate and glutamate metabolism
            osa00270  Cysteine and methionine metabolism
            osa00430  Taurine and hypotaurine metabolism
            osa00460  Cyanoamino acid metabolism
KO_PATHWAY  ko00480
///
