ENTRY       osa00290                    Pathway
NAME        Valine, leucine and isoleucine biosynthesis - Oryza sativa japonica (Japanese rice) (RefSeq)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP osa00290  Valine, leucine and isoleucine biosynthesis
MODULE      osa_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:osa00290]
            osa_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:osa00290]
            osa_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:osa00290]
DBLINKS     GO: 0009097 0009098 0009099
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4333898  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            4328147  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
            4330192  3-isopropylmalate dehydratase small subunit 3 [KO:K01704] [EC:4.2.1.33 4.2.1.35]
            4333613  3-isopropylmalate dehydrogenase 2, chloroplastic [KO:K00052] [EC:1.1.1.85]
            4329450  acetolactate synthase 1, chloroplastic [KO:K01652] [EC:2.2.1.6]
            4335672  probable acetolactate synthase 2, chloroplastic [KO:K01652] [EC:2.2.1.6]
            4329938  acetolactate synthase small subunit 2, chloroplastic isoform X1 [KO:K01653] [EC:2.2.1.6]
            4350218  acetolactate synthase small subunit 2, chloroplastic [KO:K01653] [EC:2.2.1.6]
            4339677  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
            4325375  ketol-acid reductoisomerase, chloroplastic-like [KO:K00053] [EC:1.1.1.86]
            4346318  dihydroxy-acid dehydratase, chloroplastic [KO:K01687] [EC:4.2.1.9]
            4339583  branched-chain-amino-acid aminotransferase 5, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
            4331322  branched-chain-amino-acid aminotransferase 5, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
            4332151  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            4336645  branched-chain-amino-acid aminotransferase 3, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
            4351460  2-isopropylmalate synthase A [KO:K01649] [EC:2.3.3.13]
            4349745  2-isopropylmalate synthase A [KO:K01649] [EC:2.3.3.13]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00109  2-Oxobutanoate
            C00123  L-Leucine
            C00141  3-Methyl-2-oxobutanoic acid
            C00183  L-Valine
            C00188  L-Threonine
            C00233  4-Methyl-2-oxopentanoate
            C00407  L-Isoleucine
            C00671  (S)-3-Methyl-2-oxopentanoic acid
            C02226  2-Methylmaleate
            C02504  alpha-Isopropylmalate
            C02612  (R)-2-Methylmalate
            C02631  2-Isopropylmaleate
            C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
            C04236  (2S)-2-Isopropyl-3-oxosuccinate
            C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
            C04411  (2R,3S)-3-Isopropylmalate
            C06006  (S)-2-Aceto-2-hydroxybutanoate
            C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
            C06010  (S)-2-Acetolactate
            C06032  D-erythro-3-Methylmalate
            C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
REFERENCE   PMID:15292141
  AUTHORS   Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  TITLE     Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  JOURNAL   J Bacteriol 186:5400-9 (2004)
            DOI:10.1128/JB.186.16.5400-5409.2004
REL_PATHWAY osa00260  Glycine, serine and threonine metabolism
            osa00280  Valine, leucine and isoleucine degradation
            osa00620  Pyruvate metabolism
KO_PATHWAY  ko00290
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