ENTRY       osa00260                    Pathway
NAME        Glycine, serine and threonine metabolism - Oryza sativa japonica (Japanese rice) (RefSeq)
DESCRIPTION Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP osa00260  Glycine, serine and threonine metabolism
MODULE      osa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:osa00260]
            osa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:osa00260]
            osa_M00555  Betaine biosynthesis, choline => betaine [PATH:osa00260]
DBLINKS     GO: 0006544 0006563 0070178 0006566
ORGANISM    Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
GENE        4326958  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
            4334794  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
            4342980  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
            4346642  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            4345328  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            4334188  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
            4331255  homoserine kinase [KO:K00872] [EC:2.7.1.39]
            4339521  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
            4325651  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
            4336402  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
            4338868  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
            4324773  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
            4350456  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
            4334048  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
            4352058  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
            4345962  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            4327981  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
            4334916  glyoxylate/hydroxypyruvate reductase HPR3 isoform X1 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            4334914  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            4334915  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            4334913  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            4330747  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
            9270925  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
            4327493  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            4339133  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            4332728  2,3-bisphosphoglycerate-independent phosphoglycerate mutase isoform X1 [KO:K15633] [EC:5.4.2.12]
            4324401  D-glycerate 3-kinase, chloroplastic isoform X1 [KO:K15918] [EC:2.7.1.31]
            4337230  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            4341713  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            4345710  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            9270715  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
            4350964  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
            4352281  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
            4336153  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
            4340945  primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
            4335335  LOW QUALITY PROTEIN: primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            107276105  copper methylamine oxidase-like [KO:K00276] [EC:1.4.3.21]
            4343673  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            4340946  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            4325932  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            4341516  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            4337051  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
            4326980  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
            4337862  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
            4326849  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
            4337881  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
            4341790  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
            4349114  glycine cleavage system H protein, mitochondrial [KO:K02437]
            4328441  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
            9269154  uncharacterized protein LOC9269154 [KO:K02437]
            4331779  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            4332775  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            4339095  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            4342210  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
            9272377  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
            4345606  betaine aldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
            4336081  betaine aldehyde dehydrogenase 1 [KO:K00130] [EC:1.2.1.8]
            4347172  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            4327296  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            107276062  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            4352447  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            4333898  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            4336624  serine racemase [KO:K12235] [EC:5.1.1.18]
            4342571  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
            4334425  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
            4344612  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
            4341584  tryptophan synthase beta chain 2 isoform X1 [KO:K06001] [EC:4.2.1.20]
COMPOUND    C00011  CO2
            C00014  Ammonia
            C00022  Pyruvate
            C00037  Glycine
            C00048  Glyoxylate
            C00049  L-Aspartate
            C00065  L-Serine
            C00078  L-Tryptophan
            C00097  L-Cysteine
            C00101  Tetrahydrofolate
            C00109  2-Oxobutanoate
            C00114  Choline
            C00143  5,10-Methylenetetrahydrofolate
            C00168  Hydroxypyruvate
            C00188  L-Threonine
            C00197  3-Phospho-D-glycerate
            C00213  Sarcosine
            C00258  D-Glycerate
            C00263  L-Homoserine
            C00300  Creatine
            C00430  5-Aminolevulinate
            C00441  L-Aspartate 4-semialdehyde
            C00546  Methylglyoxal
            C00576  Betaine aldehyde
            C00581  Guanidinoacetate
            C00631  2-Phospho-D-glycerate
            C00719  Betaine
            C00740  D-Serine
            C00986  1,3-Diaminopropane
            C01005  O-Phospho-L-serine
            C01026  N,N-Dimethylglycine
            C01102  O-Phospho-L-homoserine
            C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
            C01888  Aminoacetone
            C02051  Lipoylprotein
            C02291  L-Cystathionine
            C02737  Phosphatidylserine
            C02972  Dihydrolipoylprotein
            C03082  4-Phospho-L-aspartate
            C03194  (R)-1-Aminopropan-2-ol
            C03232  3-Phosphonooxypyruvate
            C03283  L-2,4-Diaminobutanoate
            C03508  L-2-Amino-3-oxobutanoic acid
            C05519  L-Allothreonine
            C06231  Ectoine
            C06442  N(gamma)-Acetyldiaminobutyrate
            C16432  5-Hydroxyectoine
            C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:11823218
  AUTHORS   Kuhlmann AU, Bremer E.
  TITLE     Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  JOURNAL   Appl Environ Microbiol 68:772-83 (2002)
            DOI:10.1128/AEM.68.2.772-783.2002
REFERENCE   PMID:10473374
  AUTHORS   Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  TITLE     Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  JOURNAL   Appl Environ Microbiol 65:3774-9 (1999)
            DOI:10.1128/AEM.65.9.3774-3779.1999
REFERENCE   PMID:17636255
  AUTHORS   Bursy J, Pierik AJ, Pica N, Bremer E.
  TITLE     Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  JOURNAL   J Biol Chem 282:31147-55 (2007)
            DOI:10.1074/jbc.M704023200
REFERENCE   PMID:16707670
  AUTHORS   Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  TITLE     The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  JOURNAL   J Bacteriol 188:3774-84 (2006)
            DOI:10.1128/JB.00136-06
REFERENCE   PMID:15470257
  AUTHORS   Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  TITLE     FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  JOURNAL   Eukaryot Cell 3:1287-96 (2004)
            DOI:10.1128/EC.3.5.1287-1296.2004
REFERENCE   PMID:7639721
  AUTHORS   Rees WD, Hay SM
  TITLE     The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  JOURNAL   Biochem J 309 ( Pt 3):999-1007 (1995)
            DOI:10.1042/bj3090999
REFERENCE   PMID:11341914
  AUTHORS   Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  TITLE     Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  JOURNAL   Biochim Biophys Acta 1544:28-41 (2001)
            DOI:10.1016/S0167-4838(00)00203-X
REFERENCE   PMID:15520012
  AUTHORS   Chen X, Jhee KH, Kruger WD
  TITLE     Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  JOURNAL   J Biol Chem 279:52082-6 (2004)
            DOI:10.1074/jbc.C400481200
REL_PATHWAY osa00010  Glycolysis / Gluconeogenesis
            osa00020  Citrate cycle (TCA cycle)
            osa00230  Purine metabolism
            osa00250  Alanine, aspartate and glutamate metabolism
            osa00270  Cysteine and methionine metabolism
            osa00290  Valine, leucine and isoleucine biosynthesis
            osa00300  Lysine biosynthesis
            osa00330  Arginine and proline metabolism
            osa00460  Cyanoamino acid metabolism
            osa00470  D-Amino acid metabolism
            osa00564  Glycerophospholipid metabolism
            osa00600  Sphingolipid metabolism
            osa00620  Pyruvate metabolism
            osa00630  Glyoxylate and dicarboxylate metabolism
            osa00640  Propanoate metabolism
            osa00860  Porphyrin metabolism
            osa00920  Sulfur metabolism
KO_PATHWAY  ko00260
///
