ENTRY       mtr04146                    Pathway
NAME        Peroxisome - Medicago truncatula (barrel medic)
DESCRIPTION Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP mtr04146  Peroxisome
DBLINKS     GO: 0005777
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        25500979  peroxisome biogenesis protein 16 [KO:K13335]
            11411176  peroxisome biogenesis protein 3-2 [KO:K13336]
            11410991  peroxisome biogenesis protein 19-2 [KO:K13337]
            11445708  peroxisome biogenesis protein 1 isoform X1 [KO:K13338]
            11417625  peroxisome biogenesis protein 6 [KO:K13339]
            25485966  peroxisome biogenesis protein 7 [KO:K13341]
            11409138  peroxisome biogenesis protein 5 [KO:K13342]
            11440188  peroxisomal membrane protein PEX14 [KO:K13343]
            11431877  peroxisomal membrane protein 13 isoform X1 [KO:K13344]
            11421943  peroxisome biogenesis protein 12 [KO:K13345]
            11431925  peroxisome biogenesis factor 10 [KO:K13346]
            11435007  peroxisome biogenesis protein 2 [KO:K06664]
            11415018  protein sym-1 [KO:K13347]
            25486199  peroxisomal membrane protein PMP22 [KO:K13347]
            11431286  peroxisomal membrane protein PMP22 [KO:K13347]
            11416735  protein SYM1 [KO:K13348]
            25496212  PXMP2/4 family protein 4 [KO:K13348]
            11442892  protein Mpv17 [KO:K13348]
            25487391  uncharacterized protein LOC25487391 [KO:K13348]
            25487620  protein SYM1 [KO:K13348]
            11430561  PXMP2/4 family protein 2 [KO:K13348]
            25485355  PXMP2/4 family protein 4 [KO:K13348]
            11413740  peroxisomal nicotinamide adenine dinucleotide carrier [KO:K13354]
            25482755  peroxisomal nicotinamide adenine dinucleotide carrier [KO:K13354]
            25495093  2-hydroxyacyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
            25492992  phytanoyl-CoA dioxygenase isoform X1 [KO:K00477] [EC:1.14.11.18]
            25501936  acyl-coenzyme A oxidase 2, peroxisomal [KO:K00232] [EC:1.3.3.6]
            25498770  acyl-coenzyme A oxidase 4, peroxisomal [KO:K00232] [EC:1.3.3.6]
            11443699  acyl-coenzyme A oxidase 3, peroxisomal [KO:K00232] [EC:1.3.3.6]
            11407818  peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
            11435602  peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
            11417930  3-ketoacyl CoA thiolase 1, peroxisomal [KO:K07513] [EC:2.3.1.16]
            25483109  3-ketoacyl-CoA thiolase 2, peroxisomal [KO:K07513] [EC:2.3.1.16]
            25502359  peroxisomal 2,4-dienoyl-CoA reductase [KO:K13237] [EC:1.3.1.124]
            11418463  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal [KO:K12663] [EC:5.3.3.21]
            11417619  ABC transporter D family member 1 [KO:K25819] [EC:7.6.2.4]
            11410333  probable acyl-activating enzyme 16, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11436555  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
            11429070  probable acyl-activating enzyme 16, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11438515  probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3]
            11414801  LOW QUALITY PROTEIN: long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
            25502179  long chain acyl-CoA synthetase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
            11419994  long chain acyl-CoA synthetase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
            25482683  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            25492683  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            11426097  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            11437197  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            11409239  long chain acyl-CoA synthetase 9, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11422879  long chain acyl-CoA synthetase 6, peroxisomal [KO:K01897] [EC:6.2.1.3]
            11427214  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
            11439307  nudix hydrolase 15, mitochondrial [KO:K17879] [EC:3.6.1.-]
            11437729  nudix hydrolase 19, chloroplastic [KO:K03426] [EC:3.6.1.22]
            25486745  nudix hydrolase 19, chloroplastic [KO:K03426] [EC:3.6.1.22]
            25486227  malonyl-CoA decarboxylase, mitochondrial isoform X2 [KO:K01578] [EC:4.1.1.9]
            11406049  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            11425913  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            11446357  probable fatty acyl-CoA reductase 4 [KO:K13356] [EC:1.2.1.84]
            11444553  fatty acyl-CoA reductase 1 [KO:K13356] [EC:1.2.1.84]
            11446356  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            11446986  fatty acyl-CoA reductase 1 isoform X1 [KO:K13356] [EC:1.2.1.84]
            11423429  LOW QUALITY PROTEIN: probable fatty acyl-CoA reductase 4 [KO:K13356] [EC:1.2.1.84]
            11413618  probable fatty acyl-CoA reductase 4 [KO:K13356] [EC:1.2.1.84]
            25492296  alcohol-forming fatty acyl-CoA reductase [KO:K13356] [EC:1.2.1.84]
            25483583  fatty acyl-CoA reductase 2, chloroplastic [KO:K13356] [EC:1.2.1.84]
            11429779  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
            11440516  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            11423326  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            11445769  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            11425956  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
            11419675  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            11442282  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            11432002  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            11406357  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            11413302  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            25487060  peroxisomal (S)-2-hydroxy-acid oxidase isoform X1 [KO:K11517] [EC:1.1.3.15]
            120577450  (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            120577451  (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            120577452  (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            120577602  (S)-2-hydroxy-acid oxidase GLO1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
            120577617  (S)-2-hydroxy-acid oxidase GLO1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
            25490307  catalase-4 [KO:K03781] [EC:1.11.1.6]
            11432262  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
            11406426  superoxide dismutase [Cu-Zn], chloroplastic [KO:K04565] [EC:1.15.1.1]
            11417511  superoxide dismutase [Cu-Zn] 2 [KO:K04565] [EC:1.15.1.1]
            25489595  superoxide dismutase [Fe] 3, chloroplastic [KO:K04564] [EC:1.15.1.1]
            25489848  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
            25483199  superoxide dismutase [Fe], chloroplastic isoform X1 [KO:K04564] [EC:1.15.1.1]
            11431418  xanthine dehydrogenase 1 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
            11439071  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
REFERENCE   PMID:17055078
  AUTHORS   Wanders RJ, Waterham HR
  TITLE     Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  JOURNAL   Biochim Biophys Acta 1763:1707-20 (2006)
            DOI:10.1016/j.bbamcr.2006.08.010
REFERENCE   PMID:17055079
  AUTHORS   Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  TITLE     Peroxisome biogenesis disorders.
  JOURNAL   Biochim Biophys Acta 1763:1733-48 (2006)
            DOI:10.1016/j.bbamcr.2006.09.010
REFERENCE   PMID:17010456
  AUTHORS   Rottensteiner H, Theodoulou FL
  TITLE     The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  JOURNAL   Biochim Biophys Acta 1763:1527-40 (2006)
            DOI:10.1016/j.bbamcr.2006.08.012
REFERENCE   PMID:16631601
  AUTHORS   Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  TITLE     Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  JOURNAL   Biochem Biophys Res Commun 344:948-54 (2006)
            DOI:10.1016/j.bbrc.2006.04.008
REL_PATHWAY mtr00071  Fatty acid degradation
            mtr00230  Purine metabolism
            mtr00564  Glycerophospholipid metabolism
            mtr00565  Ether lipid metabolism
            mtr00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko04146
///
