ENTRY       mtr04145                    Pathway
NAME        Phagosome - Medicago truncatula (barrel medic)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP mtr04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11443508  syntaxin-22 [KO:K08488]
            11424830  syntaxin-22 [KO:K08488]
            11427617  syntaxin-22 [KO:K08488]
            25496850  syntaxin-81 [KO:K08492]
            11420702  25.3 kDa vesicle transport protein [KO:K08517]
            25485078  25.3 kDa vesicle transport protein [KO:K08517]
            11406551  ras-related protein RHN1 isoform X1 [KO:K07888]
            11427184  ras-related protein RHN1 [KO:K07889]
            11417941  ras-related protein RHN1 [KO:K07889]
            11435335  ras-related protein RHN1 [KO:K07889]
            11415599  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            25491171  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
            25485635  V-type proton ATPase subunit B2 [KO:K02147]
            11426878  V-type proton ATPase subunit B2 [KO:K02147]
            11429113  V-type proton ATPase subunit C [KO:K02148]
            11424764  V-type proton ATPase subunit D [KO:K02149]
            25492792  V-type proton ATPase subunit E2 [KO:K02150]
            25502144  V-type proton ATPase subunit E isoform X1 [KO:K02150]
            11438964  V-type proton ATPase subunit E [KO:K02150]
            120577678  V-type proton ATPase subunit F [KO:K02151]
            25484007  V-type proton ATPase subunit G [KO:K02152]
            11432938  V-type proton ATPase subunit G1 [KO:K02152]
            112419848  V-type proton ATPase subunit e1 [KO:K02153]
            11425878  V-type proton ATPase subunit e2 [KO:K02153]
            11411441  V-type proton ATPase subunit a1 isoform X1 [KO:K02154]
            11416913  V-type proton ATPase subunit a1 isoform X1 [KO:K02154]
            11440569  V-type proton ATPase subunit a3 [KO:K02154]
            25490246  V-type proton ATPase subunit a2 [KO:K02154]
            25497487  V-type proton ATPase subunit d1 [KO:K02146]
            11410508  V-type proton ATPase subunit d2 [KO:K02146]
            11417957  V-type proton ATPase subunit H [KO:K02144]
            11408165  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            11442794  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            11420538  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            11414044  V-type proton ATPase subunit c''2 [KO:K03661]
            11436176  ras-related protein Rab7 [KO:K07897]
            11434770  ras-related protein Rab7 [KO:K07897]
            25496256  ras-related protein Rab7 [KO:K07897]
            25481755  ras-related protein Rab7 isoform X1 [KO:K07897]
            112417794  ras-related protein Rab7 isoform X1 [KO:K07897]
            11411545  ras-related protein Rab7 [KO:K07897]
            11417478  ras-related protein Rab7 [KO:K07897]
            120580833  ras-related protein Rab7-like [KO:K07897]
            120580835  ras-related protein Rab7-like [KO:K07897]
            120580887  ras-related protein Rab7-like [KO:K07897]
            25485026  ras-related protein Rab7 [KO:K07897]
            11408319  tubulin alpha-5 chain [KO:K07374]
            25486488  tubulin alpha-2 chain [KO:K07374]
            11432745  tubulin alpha-1 chain [KO:K07374]
            11415454  tubulin alpha-1 chain [KO:K07374]
            25486510  tubulin alpha-2 chain isoform X1 [KO:K07374]
            11416880  tubulin alpha-3 chain [KO:K07374]
            11441048  tubulin alpha-1 chain [KO:K07374]
            25485311  tubulin alpha chain [KO:K07374]
            11414871  tubulin beta chain [KO:K07375]
            11438618  tubulin beta-1 chain [KO:K07375]
            11415767  tubulin beta chain [KO:K07375]
            11442516  tubulin beta chain [KO:K07375]
            11437601  tubulin beta-2 chain [KO:K07375]
            11439086  tubulin beta-2 chain [KO:K07375]
            25491473  tubulin beta-1 chain [KO:K07375]
            25493371  tubulin beta chain [KO:K07375]
            11425110  tubulin beta-8 chain [KO:K07375]
            11422693  tubulin beta-3 chain [KO:K07375]
            11446911  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            11418609  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B isoform X1 [KO:K00921] [EC:2.7.1.150]
            25493029  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            25485003  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
            11408450  protein transport protein Sec61 subunit alpha [KO:K10956]
            11408264  protein transport protein Sec61 subunit alpha [KO:K10956]
            25488366  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            11413802  protein transport protein Sec61 subunit beta [KO:K09481]
            11422146  protein transport protein Sec61 subunit beta [KO:K09481]
            11419972  protein transport protein Sec61 subunit beta [KO:K09481]
            11405922  protein transport protein Sec61 subunit beta [KO:K09481]
            11446014  protein transport protein Sec61 subunit gamma [KO:K07342]
            11424024  protein transport protein Sec61 subunit gamma [KO:K07342]
            11413905  calreticulin-3 [KO:K08057]
            11437433  calreticulin-3 isoform X1 [KO:K08057]
            11416675  calreticulin isoform X1 [KO:K08057]
            11436291  calnexin homolog [KO:K08054]
            11434549  calnexin homolog [KO:K08054]
            11438687  rac-like GTP-binding protein RHO1 [KO:K04392]
            11445417  rac-like GTP-binding protein RAC1 [KO:K04392]
            25493052  rac-like GTP-binding protein RAC13 [KO:K04392]
            11421840  rac-like GTP-binding protein RHO1 [KO:K04392]
            25489548  rac-like GTP-binding protein ARAC8 [KO:K04392]
            11436245  rac-like GTP-binding protein ARAC7 [KO:K04392]
            25487731  rac-like GTP-binding protein RAC2 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY mtr04144  Endocytosis
KO_PATHWAY  ko04145
///
