ENTRY       mtr04141                    Pathway
NAME        Protein processing in endoplasmic reticulum - Medicago truncatula (barrel medic)
DESCRIPTION The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP mtr04141  Protein processing in endoplasmic reticulum
DBLINKS     GO: 0030433 0034976
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11408450  protein transport protein Sec61 subunit alpha [KO:K10956]
            11408264  protein transport protein Sec61 subunit alpha [KO:K10956]
            25488366  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            11413802  protein transport protein Sec61 subunit beta [KO:K09481]
            11422146  protein transport protein Sec61 subunit beta [KO:K09481]
            11419972  protein transport protein Sec61 subunit beta [KO:K09481]
            11405922  protein transport protein Sec61 subunit beta [KO:K09481]
            11446014  protein transport protein Sec61 subunit gamma [KO:K07342]
            11424024  protein transport protein Sec61 subunit gamma [KO:K07342]
            11443180  uncharacterized protein LOC11443180 [KO:K12275]
            11443293  dnaJ protein ERDJ2A [KO:K09540]
            11422511  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
            11419421  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
            25484247  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
            11421886  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
            11430971  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
            25485242  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K12669]
            25492724  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
            11417285  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
            11419582  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
            25501732  mannosyl-oligosaccharide glucosidase GCS1 isoform X2 [KO:K01228] [EC:3.2.1.106]
            25489620  heat shock 70 kDa protein 17 [KO:K09486]
            25502230  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
            25502238  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
            11432032  dnaJ protein ERDJ3B [KO:K09517]
            11434754  dnaJ protein P58IPK homolog [KO:K09523]
            25479542  heat shock protein 90-5, chloroplastic [KO:K09487]
            11419641  heat shock protein 90-6, mitochondrial [KO:K09487]
            11445571  endoplasmin homolog [KO:K09487]
            11424998  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
            11441385  glucosidase 2 subunit beta isoform X2 [KO:K08288]
            11436291  calnexin homolog [KO:K08054]
            11434549  calnexin homolog [KO:K08054]
            11413905  calreticulin-3 [KO:K08057]
            11437433  calreticulin-3 isoform X1 [KO:K08057]
            11416675  calreticulin isoform X1 [KO:K08057]
            120575730  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like isoform X1 [KO:K01230] [EC:3.2.1.113]
            25491240  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
            11438644  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 isoform X1 [KO:K01230] [EC:3.2.1.113]
            11438869  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
            25492998  SEC12-like protein 2 [KO:K14003]
            25484857  SEC12-like protein 1 [KO:K14003]
            11410239  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            25499653  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            11427896  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            25489031  protein transport protein SEC13 homolog B [KO:K14004]
            25492007  protein transport protein SEC31 homolog B [KO:K14005]
            11420685  protein transport protein SEC23 [KO:K14006]
            11432736  protein transport protein SEC23 [KO:K14006]
            25485261  protein transport protein SEC23 [KO:K14006]
            11429581  protein transport protein Sec24-like At3g07100 [KO:K14007]
            25485594  protein transport protein Sec24-like At4g32640 [KO:K14007]
            11421594  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
            11407473  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
            25484459  alpha-mannosidase I MNS4 isoform X1 [KO:K10085]
            11414757  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
            11436358  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
            11426406  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
            25489685  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
            25484986  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
            25499648  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
            120578286  ribonuclease DdI-like [KO:K09584] [EC:5.3.4.1]
            11434558  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
            11412950  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
            11408999  endoplasmic reticulum oxidoreductin-2 [KO:K10950] [EC:1.8.4.-]
            25488334  protein OS-9 homolog [KO:K10088]
            11421535  translocon-associated protein subunit alpha [KO:K13249]
            11443646  translocon-associated protein subunit alpha [KO:K13249]
            11443082  translocon-associated protein subunit beta [KO:K13250]
            11411413  B-cell receptor-associated protein 31 [KO:K14009]
            25498259  uncharacterized protein LOC25498259 [KO:K14009]
            11444046  B-cell receptor-associated protein 31 [KO:K14009]
            25486201  uncharacterized protein LOC25486201 [KO:K14009]
            11412878  derlin-1 [KO:K13989]
            25490344  derlin-1 [KO:K13989]
            25486133  derlin-2.2 [KO:K13989]
            11411366  UBX domain-containing protein 1 [KO:K24348]
            11412894  plant UBX domain-containing protein 2 [KO:K14011]
            11430595  plant UBX domain-containing protein 4 [KO:K14012]
            25486233  plant UBX domain-containing protein 4 [KO:K14012]
            25487843  cell division cycle protein 48 homolog [KO:K13525]
            25483983  cell division control protein 48 homolog E [KO:K13525]
            11432951  cell division control protein 48 homolog D [KO:K13525]
            25499572  NPL4-like protein 1 [KO:K14015]
            11406565  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            11415947  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            11417447  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
            11412947  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
            11433850  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
            11442919  heat shock 70 kDa protein [KO:K03283]
            11438322  heat shock 70 kDa protein 4 [KO:K03283]
            11439333  heat shock 70 kDa protein [KO:K03283]
            11417074  heat shock 70 kDa protein 4 [KO:K03283]
            11437702  heat shock cognate 70 kDa protein [KO:K03283]
            11438126  heat shock cognate 70 kDa protein [KO:K03283]
            25496003  heat shock cognate 70 kDa protein [KO:K03283]
            25495984  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein [KO:K03283]
            25497411  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein [KO:K03283]
            25497853  heat shock cognate 70 kDa protein [KO:K03283]
            25499929  heat shock cognate 70 kDa protein [KO:K03283]
            11443306  heat shock cognate 70 kDa protein [KO:K03283]
            25500956  heat shock 70 kDa protein 4 [KO:K03283]
            25495969  heat shock 70 kDa protein 18 [KO:K03283]
            25495973  heat shock 70 kDa protein 18 [KO:K03283]
            25495977  heat shock 70 kDa protein 18 [KO:K03283]
            25495983  heat shock 70 kDa protein 18 [KO:K03283]
            25495985  heat shock cognate 70 kDa protein 2 [KO:K03283]
            25495997  heat shock 70 kDa protein 18 [KO:K03283]
            25491671  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein [KO:K03283]
            11419378  heat shock cognate 70 kDa protein [KO:K03283]
            25492495  heat shock cognate 70 kDa protein 2 [KO:K03283]
            25492496  heat shock cognate 70 kDa protein 2 [KO:K03283]
            11443124  heat shock 70 kDa protein [KO:K03283]
            11433698  heat shock cognate 70 kDa protein [KO:K03283]
            25486072  heat shock cognate 70 kDa protein [KO:K03283]
            11438302  heat shock cognate 70 kDa protein [KO:K03283]
            11443338  heat shock cognate 70 kDa protein 2 [KO:K03283]
            11443341  heat shock cognate 70 kDa protein 2 [KO:K03283]
            11440833  heat shock 70 kDa protein 4 [KO:K03283]
            11442942  heat shock 70 kDa protein 4 isoform X1 [KO:K03283]
            11438873  heat shock 70 kDa protein 4 [KO:K03283]
            11439796  heat shock cognate 70 kDa protein [KO:K03283]
            11440835  heat shock cognate 70 kDa protein [KO:K03283]
            11440836  heat shock cognate 70 kDa protein [KO:K03283]
            11440351  heat shock cognate 70 kDa protein [KO:K03283]
            11443351  heat shock 70 kDa protein 4 [KO:K03283]
            11446123  heat shock cognate 70 kDa protein [KO:K03283]
            11432624  heat shock cognate 70 kDa protein [KO:K03283]
            11430131  heat shock cognate 70 kDa protein [KO:K03283]
            11423681  heat shock cognate 70 kDa protein 2 [KO:K03283]
            11436580  chaperone protein dnaJ 3 [KO:K09503]
            11414402  dnaJ protein homolog 2 [KO:K09503]
            11444505  dnaJ protein homolog [KO:K09503]
            25488117  chaperone protein dnaJ 49 [KO:K09518]
            120578204  chaperone protein dnaJ 49-like [KO:K09518]
            25488116  chaperone protein dnaJ 49 [KO:K09518]
            25497103  heat shock protein 83 [KO:K04079]
            11439895  heat shock cognate protein 80 [KO:K04079]
            11423533  heat shock cognate protein 80 [KO:K04079]
            11429039  nucleotide exchange factor SIL1 [KO:K09562]
            11419264  hsp70 nucleotide exchange factor FES1 [KO:K09562]
            11443379  17.4 kDa class III heat shock protein [KO:K13993]
            11424682  17.8 kDa class I heat shock protein [KO:K13993]
            25479774  18.1 kDa class I heat shock protein [KO:K13993]
            11428272  small heat shock protein, chloroplastic [KO:K13993]
            25479450  heat shock 22 kDa protein, mitochondrial isoform X2 [KO:K13993]
            112420914  LOW QUALITY PROTEIN: class I heat shock protein-like [KO:K13993]
            11421347  22.7 kDa class IV heat shock protein [KO:K13993]
            11419465  small heat shock protein, chloroplastic [KO:K13993]
            25495898  LOW QUALITY PROTEIN: 17.3 kDa class II heat shock protein [KO:K13993]
            120576134  18.5 kDa class I heat shock protein-like [KO:K13993]
            11425749  17.1 kDa class II heat shock protein [KO:K13993]
            11429344  26.5 kDa heat shock protein, mitochondrial isoform X1 [KO:K13993]
            11421034  small heat shock protein, chloroplastic-like [KO:K13993]
            25493107  18.2 kDa class I heat shock protein [KO:K13993]
            11435072  18.1 kDa class I heat shock protein [KO:K13993]
            25492559  17.5 kDa class I heat shock protein [KO:K13993]
            25493103  18.5 kDa class I heat shock protein [KO:K13993]
            25493104  18.1 kDa class I heat shock protein [KO:K13993]
            25493110  18.1 kDa class I heat shock protein [KO:K13993]
            11413453  heat shock 22 kDa protein, mitochondrial [KO:K13993]
            11429361  17.5 kDa class I heat shock protein [KO:K13993]
            11436445  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
            25486134  15.4 kDa class V heat shock protein [KO:K13993]
            11415795  18.1 kDa class I heat shock protein [KO:K13993]
            11416008  class I heat shock protein [KO:K13993]
            11410483  18.1 kDa class I heat shock protein [KO:K13993]
            11409076  18.1 kDa class I heat shock protein [KO:K13993]
            25481986  17.9 kDa class II heat shock protein [KO:K13993]
            25484498  22.7 kDa class IV heat shock protein [KO:K13993]
            25484500  22.7 kDa class IV heat shock protein [KO:K13993]
            25484501  22.7 kDa class IV heat shock protein [KO:K13993]
            25484502  22.7 kDa class IV heat shock protein [KO:K13993]
            25484503  22.7 kDa class IV heat shock protein [KO:K13993]
            11425861  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
            112421274  uncharacterized protein LOC112421274 isoform X13 [KO:K14018]
            25492716  phospholipase A-2-activating protein [KO:K14018]
            25499820  ubiquitin receptor RAD23d [KO:K10839]
            25488002  ubiquitin receptor RAD23b [KO:K10839]
            25485511  ubiquitin receptor RAD23c [KO:K10839]
            11444846  ubiquitin domain-containing protein DSK2a [KO:K04523]
            11444847  ubiquitin domain-containing protein DSK2b isoform X1 [KO:K04523]
            11410903  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
            11433336  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
            11428042  ataxin-3 homolog isoform X1 [KO:K11863] [EC:3.4.22.-]
            11412513  probable ubiquitin conjugation factor E4 isoform X1 [KO:K10597] [EC:2.3.2.27]
            25492659  eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
            11417999  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
            11410362  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
            11418000  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
            11426104  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
            11421731  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
            11418562  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            11421747  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            11410940  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            11441397  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
            11414701  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            11443912  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            11422025  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            25487868  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            11441665  ERAD-associated E3 ubiquitin-protein ligase HRD1A [KO:K10601] [EC:2.3.2.27]
            11433721  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
            25502627  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            120577629  E3 ubiquitin-protein ligase RMA3-like [KO:K10666] [EC:2.3.2.27]
            11432860  uncharacterized protein LOC11432860 isoform X1 [KO:K10666] [EC:2.3.2.27]
            120580722  E3 ubiquitin-protein ligase RMA2-like [KO:K10666] [EC:2.3.2.27]
            25493170  E3 ubiquitin-protein ligase RMA3 [KO:K10666] [EC:2.3.2.27]
            25493171  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            11405855  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
            25485936  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            25486843  uncharacterized protein LOC25486843 [KO:K10666] [EC:2.3.2.27]
            25487645  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            25487651  E3 ubiquitin-protein ligase RMA1H1 isoform X1 [KO:K10666] [EC:2.3.2.27]
            25482097  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            25483535  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
            11418492  uncharacterized protein LOC11418492 [KO:K10666] [EC:2.3.2.27]
            11415768  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
            11410500  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
            11421224  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            11437634  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K06689] [EC:2.3.2.23]
            25501549  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
            11443623  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
            11436401  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            11420397  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            11413962  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            25492127  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            11425891  cullin-1 [KO:K03347]
            25494069  cullin-1 [KO:K03347]
            25488176  cullin-1 [KO:K03347]
            11443849  SKP1-like protein 11 [KO:K03094]
            25485612  SKP1-like protein 1A [KO:K03094]
            25499072  SKP1-like protein 1A [KO:K03094]
            25499080  SKP1-like protein 1B [KO:K03094]
            11446057  SKP1-like protein 14 [KO:K03094]
            11424737  SKP1-like protein 14 [KO:K03094]
            11426194  SKP1-like protein 1A [KO:K03094]
            11434250  SKP1-like protein 1A [KO:K03094]
            25491809  SKP1-like protein 1B [KO:K03094]
            25502753  SKP1-like protein 1A [KO:K03094]
            25499058  SKP1-like protein 1 [KO:K03094]
            25499060  SKP1-like protein 1B [KO:K03094]
            25499062  SKP1-like protein 1B [KO:K03094]
            25499079  SKP1-like protein 1B [KO:K03094]
            11414605  SKP1-like protein 1A [KO:K03094]
            11429668  SKP1-like protein 1A [KO:K03094]
            11432881  SKP1-like protein 1A [KO:K03094]
            11433393  SKP1-like protein 1A [KO:K03094]
            11423233  SKP1-like protein 1A [KO:K03094]
            11425732  SKP1-like protein 1A [KO:K03094]
            25491492  SKP1-like protein 1A [KO:K03094]
            25491808  SKP1-like protein 14 [KO:K03094]
            11430287  SKP1-like protein 1B [KO:K03094]
            11429415  SKP1-like protein 1B [KO:K03094]
            25490092  SKP1-like protein 1A [KO:K03094]
            11425582  SKP1-like protein 1B [KO:K03094]
            11435518  SKP1-like protein 14 [KO:K03094]
            11408483  SKP1-like protein 1A [KO:K03094]
            11445600  SKP1-like protein 1B [KO:K03094]
            11438280  SKP1-like protein 1B isoform X1 [KO:K03094]
            11418787  SKP1-like protein 1 [KO:K03094]
COMPOUND    C00076  Calcium cation
            G00009
            G00010
            G00011
            G00012
            G10694
REFERENCE   PMID:19491040
  AUTHORS   Naidoo N
  TITLE     ER and aging-Protein folding and the ER stress response.
  JOURNAL   Ageing Res Rev 8:150-9 (2009)
            DOI:10.1016/j.arr.2009.03.001
REFERENCE   PMID:18023214
  AUTHORS   Malhotra JD, Kaufman RJ
  TITLE     The endoplasmic reticulum and the unfolded protein response.
  JOURNAL   Semin Cell Dev Biol 18:716-31 (2007)
            DOI:10.1016/j.semcdb.2007.09.003
REFERENCE   PMID:20347046
  AUTHORS   Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  TITLE     Protein quality control in the ER: the recognition of misfolded proteins.
  JOURNAL   Semin Cell Dev Biol 21:500-11 (2010)
            DOI:10.1016/j.semcdb.2010.03.006
REFERENCE   PMID:20219571
  AUTHORS   Stolz A, Wolf DH
  TITLE     Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  JOURNAL   Biochim Biophys Acta 1803:694-705 (2010)
            DOI:10.1016/j.bbamcr.2010.02.005
REFERENCE   PMID:20112977
  AUTHORS   Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  TITLE     Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  JOURNAL   J Proteome Res 9:1763-71 (2010)
            DOI:10.1021/pr900900x
REL_PATHWAY mtr00510  N-Glycan biosynthesis
            mtr03050  Proteasome
            mtr03060  Protein export
KO_PATHWAY  ko04141
///
