ENTRY       mtr04016                    Pathway
NAME        MAPK signaling pathway - plant - Medicago truncatula (barrel medic)
DESCRIPTION Mitogen-activated protein kinase (MAPK) cascades, the evolutionarily conserved signaling modules in all eukaryotes, serve in transducing extracellular signals to the nucleus or cytoplasm for appropriate cellular responses, including cell division, differentiation, programmed cell death, and adaption to various stresses. In plant, several cascades are triggered by different biotic and abiotic stress stimuli such as pathogen infection, wounding, low temperature, drought, osmotic shock, high salinity, and reactive oxygen species. MAPK pathways also play pivotal roles in processes such as hormonal and developmental signaling. Multiple functional pathways initiated from distinct receptors often share the same kinase components while maintaining their signaling specificity. In contrast to those of animals and fungi, all the plant MAPK genes that have been reported belong to extracellular signal-regulated kinase (ERK) subfamily.
CLASS       Environmental Information Processing; Signal transduction
PATHWAY_MAP mtr04016  MAPK signaling pathway - plant
DBLINKS     GO: 0000165
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        25485996  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            25502822  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            25493396  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:2.7.11.1]
            25485993  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13420] [EC:2.7.11.1]
            11421599  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            11425130  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 isoform X2 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            11430748  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 isoform X1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            11428529  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            11430344  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
            11431495  mitogen-activated protein kinase kinase kinase 1 [KO:K13414] [EC:2.7.11.25]
            25494204  mitogen-activated protein kinase kinase 2 [KO:K20603] [EC:2.7.12.2]
            25486433  mitogen-activated protein kinase kinase 2 [KO:K20603] [EC:2.7.12.2]
            25500841  mitogen-activated protein kinase homolog MMK2 [KO:K20600] [EC:2.7.11.24]
            11408151  mitogen-activated protein kinase homolog MMK2 [KO:K20600] [EC:2.7.11.24]
            11414826  protein MKS1 [KO:K20725]
            25501950  protein MKS1 [KO:K20725]
            120577936  VQ motif-containing protein 20-like [KO:K20725]
            11409601  probable WRKY transcription factor 26 [KO:K13424]
            11405228  WRKY transcription factor WRKY24 [KO:K13424]
            25491419  probable WRKY transcription factor 33 [KO:K13424]
            11415731  WRKY transcription factor WRKY24 [KO:K13424]
            11420464  mitogen-activated protein kinase kinase 4 [KO:K13413] [EC:2.7.12.2]
            11408024  mitogen-activated protein kinase 3 [KO:K20536] [EC:2.7.11.24]
            11446238  mitogen-activated protein kinase homolog MMK1 [KO:K14512] [EC:2.7.11.24]
            25496079  transcription factor VIP1 [KO:K20557]
            11419800  pathogenesis-related protein 1 [KO:K13449]
            11425148  pathogenesis-related protein 1C [KO:K13449]
            11434823  pathogenesis-related protein 1B [KO:K13449]
            11434824  pathogenesis-related protein PR-1 type [KO:K13449]
            11434825  pathogenesis-related protein 1 [KO:K13449]
            11424913  pathogenesis-related protein 1 [KO:K13449]
            11430754  pathogenesis-related protein 1B [KO:K13449]
            11424914  pathogenesis-related protein 1 [KO:K13449]
            25493257  pathogenesis-related protein 1B [KO:K13449]
            11424228  basic form of pathogenesis-related protein 1 [KO:K13449]
            11405682  basic form of pathogenesis-related protein 1 [KO:K13449]
            25492180  pathogenesis-related protein 1 [KO:K13449]
            25488053  pathogenesis-related protein 1 [KO:K13449]
            25500825  WRKY transcription factor 22 [KO:K13425]
            25486229  probable WRKY transcription factor 35 [KO:K13425]
            11406703  WRKY transcription factor 22 [KO:K13425]
            25502110  probable WRKY transcription factor 29 [KO:K13426]
            25500828  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
            25502108  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
            11426537  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
            11428596  serine/threonine-protein kinase OXI1 [KO:K20714] [EC:2.7.11.1]
            25498173  serine/threonine-protein kinase OXI1 [KO:K20714] [EC:2.7.11.1]
            25500090  nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
            11407961  nucleoside diphosphate kinase 2, chloroplastic [KO:K00940] [EC:2.7.4.6]
            11421374  mitogen-activated protein kinase kinase kinase NPK1 [KO:K20606] [EC:2.7.11.25]
            11418727  mitogen-activated protein kinase kinase 3 isoform X1 [KO:K20607] [EC:2.7.12.2]
            25490220  mitogen-activated protein kinase homolog NTF3 [KO:K20535] [EC:2.7.11.24]
            11441112  mitogen-activated protein kinase 7 [KO:K20537] [EC:2.7.11.24]
            11417991  mitogen-activated protein kinase 7 [KO:K20537] [EC:2.7.11.24]
            11430582  protein EIN4 [KO:K14509] [EC:2.7.13.-]
            25483020  ethylene receptor 2 [KO:K14509] [EC:2.7.13.-]
            11434695  ethylene receptor [KO:K14509] [EC:2.7.13.-]
            11431291  protein EIN4 [KO:K14509] [EC:2.7.13.-]
            11431567  ethylene response sensor 1 [KO:K14509] [EC:2.7.13.-]
            25484398  ethylene receptor 2 [KO:K14509] [EC:2.7.13.-]
            11423951  serine/threonine-protein kinase CTR1 isoform X1 [KO:K14510] [EC:2.7.11.1]
            25483894  serine/threonine-protein kinase CTR1 [KO:K14510] [EC:2.7.11.1]
            11412169  protein RTE1-HOMOLOG [KO:K20726]
            11418141  protein REVERSION-TO-ETHYLENE SENSITIVITY1 [KO:K20726]
            11425509  copper-transporting ATPase HMA4 [KO:K17686] [EC:7.2.2.8]
            11437639  copper-transporting ATPase RAN1 [KO:K17686] [EC:7.2.2.8]
            11411344  probable copper-transporting ATPase HMA5 [KO:K17686] [EC:7.2.2.8]
            11428787  copper-transporting ATPase PAA2, chloroplastic [KO:K17686] [EC:7.2.2.8]
            11443067  probable copper-transporting ATPase HMA5 [KO:K17686] [EC:7.2.2.8]
            25493272  copper-transporting ATPase PAA1, chloroplastic [KO:K17686] [EC:7.2.2.8]
            25493424  copper-transporting ATPase RAN1 [KO:K17686] [EC:7.2.2.8]
            11422805  mitogen-activated protein kinase kinase 9 [KO:K20604] [EC:2.7.12.2]
            11426056  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
            112418638  uncharacterized protein LOC112418638 [KO:K14514]
            11423263  ETHYLENE INSENSITIVE 3-like 3 protein [KO:K14514]
            11423005  uncharacterized protein LOC11423005 [KO:K14514]
            11427800  ETHYLENE INSENSITIVE 3-like 5 protein [KO:K14514]
            25497129  protein ETHYLENE INSENSITIVE 3 [KO:K14514]
            25489588  protein ETHYLENE INSENSITIVE 3 [KO:K14514]
            11429671  protein ETHYLENE INSENSITIVE 3 [KO:K14514]
            11443304  ETHYLENE INSENSITIVE 3-like 1 protein [KO:K14514]
            11421031  EIN3-binding F-box protein 1 [KO:K14515]
            11444427  EIN3-binding F-box protein 1 [KO:K14515]
            11424506  EIN3-binding F-box protein 1 [KO:K14515]
            11429796  5'-3' exoribonuclease 4 isoform X1 [KO:K20553] [EC:3.1.13.-]
            112421269  5'-3' exoribonuclease 4-like isoform X1 [KO:K20553] [EC:3.1.13.-]
            25499251  ethylene-response factor C3 [KO:K14516]
            25499253  ethylene-response factor C3 [KO:K14516]
            11443991  ethylene-response factor C3 [KO:K14516]
            11444139  ethylene-response factor C3 [KO:K14516]
            11445192  ethylene-response factor C3 [KO:K14516]
            11424277  ethylene-responsive transcription factor 1B [KO:K14516]
            25484268  ethylene-responsive transcription factor 1B [KO:K14516]
            25484269  ethylene-response factor C3 [KO:K14516]
            25484274  ethylene-responsive transcription factor 1B [KO:K14516]
            25484276  ethylene-responsive transcription factor 1B [KO:K14516]
            25484278  ethylene-responsive transcription factor 1B [KO:K14516]
            25484279  ethylene-responsive transcription factor 1B [KO:K14516]
            25484280  ethylene-responsive transcription factor 1B [KO:K14516]
            25484281  ethylene-responsive transcription factor 1B [KO:K14516]
            25484435  ethylene-response factor C3 [KO:K14516]
            11440541  endochitinase [KO:K20547] [EC:3.2.1.14]
            11437617  endochitinase [KO:K20547] [EC:3.2.1.14]
            11414323  endochitinase A2 [KO:K20547] [EC:3.2.1.14]
            25501594  endochitinase [KO:K20547] [EC:3.2.1.14]
            11443517  transcription factor MYC2 [KO:K13422]
            11410578  transcription factor MYC1 [KO:K13422]
            11413806  abscisic acid receptor PYL4 [KO:K14496]
            11423648  abscisic acid receptor PYL8 [KO:K14496]
            11413056  abscisic acid receptor PYL4 [KO:K14496]
            11409349  abscisic acid receptor PYR1 [KO:K14496]
            11424989  abscisic acid receptor PYL4 [KO:K14496]
            25482360  abscisic acid receptor PYL8 [KO:K14496]
            11409184  abscisic acid receptor PYL2 [KO:K14496]
            11413625  abscisic acid receptor PYL4 [KO:K14496]
            11408102  protein phosphatase 2C 56 isoform X2 [KO:K14497] [EC:3.1.3.16]
            11425747  protein phosphatase 2C 53 [KO:K14497] [EC:3.1.3.16]
            11436220  probable protein phosphatase 2C 8 [KO:K14497] [EC:3.1.3.16]
            25494205  protein phosphatase 2C 77 [KO:K14497] [EC:3.1.3.16]
            25489354  probable protein phosphatase 2C 24 [KO:K14497] [EC:3.1.3.16]
            11435594  protein phosphatase 2C 37 [KO:K14497] [EC:3.1.3.16]
            25486432  protein phosphatase 2C 56 [KO:K14497] [EC:3.1.3.16]
            25482353  protein phosphatase 2C 51 [KO:K14497] [EC:3.1.3.16]
            11431922  protein phosphatase 2C 50 [KO:K14497] [EC:3.1.3.16]
            11424194  serine/threonine-protein kinase SRK2A isoform X2 [KO:K14498] [EC:2.7.11.1]
            11417962  serine/threonine-protein kinase SRK2I [KO:K14498] [EC:2.7.11.1]
            11437259  serine/threonine-protein kinase SRK2A [KO:K14498] [EC:2.7.11.1]
            25501875  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
            11413484  serine/threonine-protein kinase SRK2I [KO:K14498] [EC:2.7.11.1]
            11436968  serine/threonine-protein kinase SAPK3-like [KO:K14498] [EC:2.7.11.1]
            25493036  serine/threonine-protein kinase SRK2E isoform X1 [KO:K14498] [EC:2.7.11.1]
            25493582  serine/threonine-protein kinase SAPK3 [KO:K14498] [EC:2.7.11.1]
            25493584  serine/threonine-protein kinase SAPK3 [KO:K14498] [EC:2.7.11.1]
            11432123  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
            25489677  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
            25489884  serine/threonine-protein kinase SRK2A [KO:K14498] [EC:2.7.11.1]
            25482657  serine/threonine-protein kinase SRK2E [KO:K14498] [EC:2.7.11.1]
            11416037  mitogen-activated protein kinase kinase kinase 17 [KO:K20716]
            11444048  mitogen-activated protein kinase kinase kinase 18 [KO:K20716]
            25490307  catalase-4 [KO:K03781] [EC:1.11.1.6]
            11421742  calmodulin-1 [KO:K02183]
            11423715  calmodulin [KO:K02183]
            11440520  calmodulin [KO:K02183]
            11436534  calmodulin [KO:K02183]
            25480533  calmodulin-1 [KO:K02183]
            112420967  uncharacterized protein LOC112420967 [KO:K02183]
            11445057  probable calcium-binding protein CML46 [KO:K02183]
            11412744  calcium-binding protein CP1 [KO:K02183]
            11446018  probable calcium-binding protein CML46 [KO:K02183]
            11408621  probable calcium-binding protein CML46 [KO:K02183]
            25489059  calmodulin [KO:K02183]
            11431828  calmodulin [KO:K02183]
            11414942  calmodulin-7 [KO:K02183]
            11422994  probable calcium-binding protein CML46 [KO:K02183]
            11434144  calmodulin-like protein 11 [KO:K02183]
            11434624  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            11441035  respiratory burst oxidase homolog protein C [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            25502123  respiratory burst oxidase homolog protein A [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            11424382  respiratory burst oxidase homolog protein D isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            11431159  respiratory burst oxidase homolog protein D [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            11430465  respiratory burst oxidase homolog protein C [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            25493885  respiratory burst oxidase homolog protein A isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            25486566  respiratory burst oxidase homolog protein E [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            11409538  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
            25486977  protein EPIDERMAL PATTERNING FACTOR 2 [KO:K20729]
            25487630  protein EPIDERMAL PATTERNING FACTOR 1 [KO:K20729]
            11428771  LRR receptor-like serine/threonine-protein kinase ERECTA [KO:K20718] [EC:2.7.11.1]
            25485110  LRR receptor-like serine/threonine-protein kinase ERL1 [KO:K20718] [EC:2.7.11.1]
            25502057  mitogen-activated protein kinase kinase kinase YODA [KO:K20717] [EC:2.7.11.25]
            11424173  mitogen-activated protein kinase kinase kinase YODA [KO:K20717] [EC:2.7.11.25]
            11441461  transcription factor SPEECHLESS [KO:K20558]
            25482367  transcription factor SPEECHLESS [KO:K20558]
REFERENCE   PMID:11875555
  AUTHORS   Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
  TITLE     MAP kinase signalling cascade in Arabidopsis innate immunity.
  JOURNAL   Nature 415:977-83 (2002)
            DOI:10.1038/415977a
REFERENCE   PMID:12119167
  AUTHORS   
  TITLE     Mitogen-activated protein kinase cascades in plants: a new nomenclature.
  JOURNAL   Trends Plant Sci 7:301-8 (2002)
            DOI:10.1016/S1360-1385(02)02302-6
REFERENCE   PMID:18570633
  AUTHORS   Colcombet J, Hirt H
  TITLE     Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes.
  JOURNAL   Biochem J 413:217-26 (2008)
            DOI:10.1042/BJ20080625
REFERENCE   PMID:18692429
  AUTHORS   Kendrick MD, Chang C
  TITLE     Ethylene signaling: new levels of complexity and regulation.
  JOURNAL   Curr Opin Plant Biol 11:479-85 (2008)
            DOI:10.1016/j.pbi.2008.06.011
REFERENCE   PMID:20441529
  AUTHORS   Rodriguez MC, Petersen M, Mundy J
  TITLE     Mitogen-activated protein kinase signaling in plants.
  JOURNAL   Annu Rev Plant Biol 61:621-49 (2010)
            DOI:10.1146/annurev-arplant-042809-112252
REFERENCE   PMID:20980831
  AUTHORS   Taj G, Agarwal P, Grant M, Kumar A
  TITLE     MAPK machinery in plants: recognition and response to different stresses through multiple signal transduction pathways.
  JOURNAL   Plant Signal Behav 5:1370-8 (2010)
            DOI:10.4161/psb.5.11.13020
REFERENCE   PMID:23263767
  AUTHORS   Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S
  TITLE     A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.
  JOURNAL   Plant Cell 24:4948-60 (2012)
            DOI:10.1105/tpc.112.104695
REFERENCE   PMID:25720833
  AUTHORS   Danquah A, de Zelicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J
  TITLE     Identification and characterization of an ABA-activated MAP kinase cascade in Arabidopsis thaliana.
  JOURNAL   Plant J 82:232-44 (2015)
            DOI:10.1111/tpj.12808
KO_PATHWAY  ko04016
///
