ENTRY       mtr03440                    Pathway
NAME        Homologous recombination - Medicago truncatula (barrel medic)
DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP mtr03440  Homologous recombination
DBLINKS     GO: 0000724
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11446584  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            11440646  DNA repair protein recA homolog 3, mitochondrial isoform X2 [KO:K03553]
            25502471  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
            25494222  DNA repair protein recA homolog 3, mitochondrial isoform X1 [KO:K03553]
            11444798  DNA polymerase I A, chloroplastic/mitochondrial isoform X1 [KO:K02335] [EC:2.7.7.7]
            11436067  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
            11444264  DNA polymerase I A, chloroplastic/mitochondrial isoform X2 [KO:K02335] [EC:2.7.7.7]
            25489600  LOW QUALITY PROTEIN: ATP-dependent DNA helicase homolog RECG, chloroplastic-like [KO:K03655] [EC:5.6.2.4]
            11422507  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:5.6.2.4]
            11435676  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
            11436847  double-strand break repair protein MRE11 [KO:K10865]
            11436414  nijmegen breakage syndrome 1 protein isoform X2 [KO:K10867]
            11443014  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
            25486045  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X2 [KO:K10683]
            11444771  BRCA1-associated RING domain protein 1 [KO:K10683]
            25482228  Fanconi anemia group J protein homolog isoform X1 [KO:K15362] [EC:5.6.2.3]
            25482443  DNA topoisomerase 2-binding protein 1 [KO:K10728]
            11412949  BRCT domain-containing protein At4g02110 isoform X1 [KO:K10728]
            11414828  uncharacterized protein LOC11414828 isoform X1 [KO:K10728]
            25489640  BRISC and BRCA1-A complex member 1 [KO:K20776]
            11414408  BRISC and BRCA1-A complex member 2 [KO:K12173]
            11434784  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
            11435666  protein BREAST CANCER SUSCEPTIBILITY 2 homolog A isoform X1 [KO:K08775]
            25495886  LOW QUALITY PROTEIN: protein BREAST CANCER SUSCEPTIBILITY 2 homolog A-like [KO:K08775]
            25480600  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like [KO:K08775]
            25489539  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            25493890  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            25486480  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            11446020  replication protein A 32 kDa subunit B [KO:K10739]
            25481878  replication protein A 32 kDa subunit A [KO:K10739]
            11433064  replication protein A 14 kDa subunit B [KO:K10740]
            25485573  replication protein A 14 kDa subunit B [KO:K10740]
            25485575  replication protein A 14 kDa subunit B [KO:K10740]
            11418607  DNA repair protein RAD51 homolog [KO:K04482]
            11419094  DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
            11434081  DNA repair protein RAD51 homolog 3 [KO:K10870]
            11446586  DNA repair protein RAD51 homolog 3 [KO:K10870]
            25492474  DNA repair protein RAD51 homolog 4 isoform X2 [KO:K10871]
            25492821  DNA repair protein XRCC2 homolog isoform X1 [KO:K10879]
            25488274  DNA repair protein XRCC3 homolog [KO:K10880]
            11441869  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            25501071  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            11408204  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            25497866  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            25498158  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
            25499904  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
            25499908  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
            25499905  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
            25499907  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            120578623  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
            25493137  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            25494466  protein CHROMATIN REMODELING 25 [KO:K10875] [EC:5.6.2.-]
            11435042  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            25488181  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            25489857  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            11437014  DNA polymerase delta small subunit [KO:K02328]
            11408397  DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
            25493347  DNA polymerase delta subunit 4 [KO:K03505]
            25493349  DNA polymerase delta subunit 4 [KO:K03505]
            25485289  DNA polymerase delta subunit 4 [KO:K03505]
            11419769  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
            11446659  ATP-dependent DNA helicase Q-like 3 isoform X1 [KO:K10901] [EC:5.6.2.4]
            11428648  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
            11437293  DNA topoisomerase 3-beta isoform X1 [KO:K03165] [EC:5.6.2.1]
            11417347  crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
            11435572  crossover junction endonuclease EME1B [KO:K10882] [EC:3.1.22.-]
REFERENCE   PMID:18086882
  AUTHORS   Maloisel L, Fabre F, Gangloff S.
  TITLE     DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  JOURNAL   Mol Cell Biol 28:1373-82 (2008)
            DOI:10.1128/MCB.01651-07
REFERENCE   PMID:17571595
  AUTHORS   Haruta-Takahashi N, Iwasaki H.
  TITLE     [Recombination mediators]
  JOURNAL   Seikagaku 79:449-53 (2007)
REFERENCE   PMID:18430459
  AUTHORS   Ouyang KJ, Woo LL, Ellis NA.
  TITLE     Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  JOURNAL   Mech Ageing Dev 129:425-40 (2008)
            DOI:10.1016/j.mad.2008.03.003
REFERENCE   PMID:15902993
  AUTHORS   Kawabata M, Kawabata T, Nishibori M.
  TITLE     Role of recA/RAD51 family proteins in mammals.
  JOURNAL   Acta Med Okayama 59:1-9 (2005)
            DOI:10.18926/AMO/31987
REFERENCE   PMID:12589470
  AUTHORS   Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  TITLE     Mitotic recombination in Saccharomyces cerevisiae.
  JOURNAL   Curr Genet 42:185-98 (2003)
            DOI:10.1007/s00294-002-0346-3
REFERENCE   PMID:16935872
  AUTHORS   Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  TITLE     Rad54: the Swiss Army knife of homologous recombination?
  JOURNAL   Nucleic Acids Res 34:4115-25 (2006)
            DOI:10.1093/nar/gkl481
REFERENCE   PMID:17395553
  AUTHORS   Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  TITLE     Recombination proteins and rescue of arrested replication forks.
  JOURNAL   DNA Repair (Amst) 6:967-80 (2007)
            DOI:10.1016/j.dnarep.2007.02.016
KO_PATHWAY  ko03440
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