ENTRY       mtr03060                    Pathway
NAME        Protein export - Medicago truncatula (barrel medic)
DESCRIPTION The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP mtr03060  Protein export
DBLINKS     GO: 0043952 0043953
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11413285  ALBINO3-like protein 1, chloroplastic [KO:K03217]
            25492494  inner membrane protein PPF-1, chloroplastic [KO:K03217]
            25493208  mitochondrial inner membrane protein OXA1 [KO:K03217]
            25493789  mitochondrial inner membrane protein OXA1 [KO:K03217]
            11407629  protein translocase subunit SecA, chloroplastic [KO:K03070] [EC:7.4.2.8]
            25489702  protein translocase subunit SECA2, chloroplastic isoform X1 [KO:K03070] [EC:7.4.2.8]
            11420996  signal recognition particle 54 kDa protein 2 [KO:K03106] [EC:3.6.5.4]
            11419634  signal recognition particle 54 kDa protein 2 isoform X1 [KO:K03106] [EC:3.6.5.4]
            11433065  signal recognition particle 54 kDa protein, chloroplastic isoform X1 [KO:K03106] [EC:3.6.5.4]
            11440916  cell division protein FtsY homolog, chloroplastic [KO:K03110]
            11408450  protein transport protein Sec61 subunit alpha [KO:K10956]
            11408264  protein transport protein Sec61 subunit alpha [KO:K10956]
            25488366  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            11413802  protein transport protein Sec61 subunit beta [KO:K09481]
            11422146  protein transport protein Sec61 subunit beta [KO:K09481]
            11419972  protein transport protein Sec61 subunit beta [KO:K09481]
            11405922  protein transport protein Sec61 subunit beta [KO:K09481]
            11446014  protein transport protein Sec61 subunit gamma [KO:K07342]
            11424024  protein transport protein Sec61 subunit gamma [KO:K07342]
            11443180  uncharacterized protein LOC11443180 [KO:K12275]
            11443293  dnaJ protein ERDJ2A [KO:K09540]
            25502230  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
            25502238  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
            25484339  signal recognition particle 9 kDa protein [KO:K03109]
            25490105  signal recognition particle 14 kDa protein [KO:K03104]
            25501703  signal recognition particle subunit SRP72 [KO:K03108]
            11442989  signal recognition particle subunit SRP68 [KO:K03107]
            25499231  signal recognition particle 19 kDa protein [KO:K03105]
            11442690  signal recognition particle receptor subunit alpha [KO:K13431]
            11446550  signal recognition particle receptor subunit beta [KO:K12272]
            11415596  signal recognition particle receptor subunit beta [KO:K12272]
            25499679  sec-independent protein translocase protein TATA, chloroplastic [KO:K03116]
            25484642  sec-independent protein translocase protein TATA, chloroplastic [KO:K03116]
            25485444  sec-independent protein translocase protein TATC, chloroplastic [KO:K03118]
            11417737  probable thylakoidal processing peptidase 2, chloroplastic [KO:K03100] [EC:3.4.21.89]
            11417003  chloroplast processing peptidase [KO:K03100] [EC:3.4.21.89]
            11431369  thylakoidal processing peptidase 1, chloroplastic [KO:K03100] [EC:3.4.21.89]
            25489691  chloroplast processing peptidase [KO:K03100] [EC:3.4.21.89]
            25501734  probable signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]
            11437567  probable signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]
            11415804  probable signal peptidase complex subunit 2 [KO:K12947] [EC:3.4.-.-]
            11430552  signal peptidase complex subunit 3B [KO:K12948] [EC:3.4.-.-]
            11423895  signal peptidase complex subunit 3B [KO:K12948] [EC:3.4.-.-]
            11427205  signal peptidase complex catalytic subunit SEC11A [KO:K13280] [EC:3.4.21.89]
            120578205  signal peptidase complex catalytic subunit SEC11A-like isoform X1 [KO:K13280] [EC:3.4.21.89]
            25501087  mitochondrial inner membrane protease subunit 1 [KO:K09647] [EC:3.4.21.-]
            11444107  mitochondrial inner membrane protease subunit 1 isoform X1 [KO:K09647] [EC:3.4.21.-]
            25487133  mitochondrial inner membrane protease subunit 1 [KO:K09647] [EC:3.4.21.-]
            120575799  mitochondrial inner membrane protease subunit 2 [KO:K09648] [EC:3.4.21.-]
REFERENCE   PMID:10087917
  AUTHORS   Dalbey RE, Robinson C.
  TITLE     Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  JOURNAL   Trends Biochem Sci 24:17-22 (1999)
            DOI:10.1016/S0968-0004(98)01333-4
REFERENCE   PMID:10652088
  AUTHORS   Berks BC, Sargent F, Palmer T.
  TITLE     The Tat protein export pathway.
  JOURNAL   Mol Microbiol 35:260-74 (2000)
            DOI:10.1046/j.1365-2958.2000.01719.x
REFERENCE   PMID:10747959
  AUTHORS   Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  TITLE     TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  JOURNAL   J Biol Chem 275:16717-22 (2000)
            DOI:10.1074/jbc.M000800200
REFERENCE   PMID:11007775
  AUTHORS   Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  TITLE     TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  JOURNAL   J Biol Chem 275:41350-7 (2000)
            DOI:10.1074/jbc.M004887200
REFERENCE   PMID:18046402
  AUTHORS   Rapoport TA
  TITLE     Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  JOURNAL   Nature 450:663-9 (2007)
            DOI:10.1038/nature06384
REFERENCE   PMID:17368028
  AUTHORS   Flower AM
  TITLE     The SecY translocation complex: convergence of genetics and structure.
  JOURNAL   Trends Microbiol 15:203-10 (2007)
            DOI:10.1016/j.tim.2007.03.001
REFERENCE   PMID:16212506
  AUTHORS   Osborne AR, Rapoport TA, van den Berg B
  TITLE     Protein translocation by the Sec61/SecY channel.
  JOURNAL   Annu Rev Cell Dev Biol 21:529-50 (2005)
            DOI:10.1146/annurev.cellbio.21.012704.133214
REFERENCE   PMID:12475201
  AUTHORS   Paetzel M, Karla A, Strynadka NC, Dalbey RE
  TITLE     Signal peptidases.
  JOURNAL   Chem Rev 102:4549-80 (2002)
            DOI:10.1021/cr010166y
REFERENCE   PMID:10924740
  AUTHORS   Paetzel M, Dalbey RE, Strynadka NC
  TITLE     The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  JOURNAL   Pharmacol Ther 87:27-49 (2000)
            DOI:10.1016/S0163-7258(00)00064-4
REFERENCE   PMID:17259602
  AUTHORS   Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  TITLE     Archaeal signal peptidases.
  JOURNAL   Microbiology 153:305-14 (2007)
            DOI:10.1099/mic.0.2006/003087-0
REFERENCE   PMID:19299134
  AUTHORS   Desvaux M, Hebraud M, Talon R, Henderson IR
  TITLE     Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  JOURNAL   Trends Microbiol 17:139-45 (2009)
            DOI:10.1016/j.tim.2009.01.004
REFERENCE   PMID:15063851
  AUTHORS   Nakatogawa H, Murakami A, Ito K
  TITLE     Control of SecA and SecM translation by protein secretion.
  JOURNAL   Curr Opin Microbiol 7:145-50 (2004)
            DOI:10.1016/j.mib.2004.01.001
KO_PATHWAY  ko03060
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