ENTRY       mtr03013                    Pathway
NAME        Nucleocytoplasmic transport - Medicago truncatula (barrel medic)
DESCRIPTION The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP mtr03013  Nucleocytoplasmic transport
DBLINKS     GO: 0050658
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11420140  aladin isoform X1 [KO:K14320]
            11445471  zinc finger CCCH domain-containing protein 16 [KO:K14321]
            11414779  protein GLE1 isoform X1 [KO:K18723]
            25492156  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            11434133  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            11428530  protein RAE1 isoform X1 [KO:K14298]
            25501437  protein RAE1 [KO:K14298]
            25485822  protein RAE1 isoform X1 [KO:K14298]
            11425603  nuclear pore complex protein NUP98B isoform X1 [KO:K14297]
            120577436  nuclear pore complex protein NUP98A-like isoform X1 [KO:K14297]
            11433942  nuclear pore complex protein NUP96 isoform X1 [KO:K14297]
            25484578  nuclear pore complex protein NUP98A isoform X2 [KO:K14297]
            25484132  LOW QUALITY PROTEIN: nuclear pore complex protein NUP214 [KO:K14317]
            11422606  nuclear pore complex protein NUP88 [KO:K14318]
            11433283  RAN GTPase-activating protein 1 [KO:K14319]
            11413176  RAN GTPase-activating protein 2 [KO:K14319]
            25493475  SUMO-conjugating enzyme SCE1 [KO:K10577]
            11410591  SUMO-conjugating enzyme SCE1 [KO:K10577]
            11434621  nuclear pore complex protein NUP85 [KO:K14304]
            25489031  protein transport protein SEC13 homolog B [KO:K14004]
            11418924  nuclear pore complex protein NUP107 [KO:K14301]
            11434873  nuclear pore complex protein NUP133 [KO:K14300]
            11419305  protein SEH1 [KO:K14299]
            11440795  nuclear pore complex protein NUP43 [KO:K14305]
            11413486  nuclear pore complex protein NUP58 [KO:K14307]
            11446407  LOW QUALITY PROTEIN: nuclear pore complex protein NUP54 [KO:K14308]
            11429886  nuclear pore complex protein NUP205 [KO:K14310]
            11442832  uncharacterized protein LOC11442832 isoform X2 [KO:K14311]
            11416753  nuclear pore complex protein NUP155 [KO:K14312]
            11427202  nuclear pore complex protein NUP93A [KO:K14309]
            11441996  nuclear pore complex protein NUP35 [KO:K14313]
            11438321  uncharacterized protein LOC11438321 [KO:K14315]
            25500139  uncharacterized protein LOC25500139 [KO:K14315]
            11428584  uncharacterized protein LOC11428584 [KO:K14315]
            25495140  nuclear pore complex protein GP210 isoform X2 [KO:K14314]
            25495542  uncharacterized protein LOC25495542 [KO:K20724]
            11418624  nuclear-pore anchor [KO:K09291]
            11435727  uncharacterized protein LOC11435727 [KO:K14295]
            11425639  importin subunit alpha [KO:K15042]
            11431310  importin subunit alpha-1a [KO:K15042]
            11410244  importin subunit alpha-2 [KO:K15042]
            25500683  importin subunit alpha-1 [KO:K15042]
            11418636  importin subunit alpha-2-like [KO:K15042]
            25499660  importin subunit alpha-1 [KO:K15042]
            25499659  importin subunit alpha-4 [KO:K15042]
            11437574  importin subunit alpha [KO:K15042]
            11435787  importin subunit alpha-2 [KO:K15042]
            11444721  importin subunit alpha-2 isoform X2 [KO:K15042]
            11444722  importin subunit alpha-2 [KO:K15042]
            25494113  importin subunit alpha [KO:K15042]
            25484035  importin subunit alpha-9 [KO:K15042]
            11440778  importin subunit alpha-2 [KO:K15042]
            25502229  importin subunit beta-1 [KO:K14293]
            25491131  importin subunit beta-1 [KO:K14293]
            25491133  importin subunit beta-1 [KO:K14293]
            25483792  importin subunit beta-1 isoform X1 [KO:K14293]
            25485640  transportin-1 [KO:K18752]
            11435742  transportin MOS14 isoform X1 [KO:K15436]
            25493785  transportin MOS14 isoform X1 [KO:K15436]
            11425121  importin-4 [KO:K20221]
            11419041  importin-5 [KO:K20222]
            11413769  importin-5 isoform X1 [KO:K20222]
            11419008  importin subunit beta-3 [KO:K20222]
            11417951  uncharacterized protein LOC11417951 [KO:K20222]
            11411237  importin-5-like [KO:K20222]
            120579600  uncharacterized protein LOC120579600 [KO:K20222]
            11436838  importin-5 [KO:K20222]
            25485757  importin beta-like SAD2 [KO:K20223]
            11438836  importin beta-like SAD2 isoform X1 [KO:K20223]
            25479554  importin-9 [KO:K20224]
            11412327  importin-11 isoform X1 [KO:K25201]
            25489491  snurportin-1 [KO:K13151]
            11437746  protein EXPORTIN 1A isoform X1 [KO:K14290]
            11435528  protein EXPORTIN 1A [KO:K14290]
            25500667  exportin-2 [KO:K18423]
            11444417  exportin-2 [KO:K18423]
            25499756  exportin-T [KO:K14288]
            25499719  exportin-4 [KO:K25203]
            11429604  protein HASTY 1 [KO:K14289]
            25483955  protein HASTY 1 [KO:K14289]
            25483289  exportin-7 isoform X1 [KO:K18460]
            11418457  exportin-7 isoform X2 [KO:K18460]
            11441617  GTP-binding nuclear protein Ran-2 [KO:K07936]
            25490031  GTP-binding nuclear protein Ran/TC4 [KO:K07936]
            25490032  GTP-binding nuclear protein Ran/TC4 [KO:K07936]
            25490033  GTP-binding nuclear protein Ran/TC4 [KO:K07936]
            11424327  elongation factor 1-alpha [KO:K03231]
            112416106  elongation factor 1-alpha-like isoform X1 [KO:K03231]
            11422538  elongation factor 1-alpha [KO:K03231]
            11427994  elongation factor 1-alpha [KO:K03231]
            11414537  elongation factor 1-alpha [KO:K03231]
            25495654  elongation factor 1-alpha [KO:K03231]
            25494617  elongation factor 1-alpha isoform X1 [KO:K03231]
            25482202  elongation factor 1-alpha isoform X1 [KO:K03231]
            11417682  sulfate adenylyltransferase subunit 1 isoform X2 [KO:K03231]
            25484712  elongation factor 1-alpha [KO:K03231]
            25485829  elongation factor 1-alpha [KO:K03231]
            25484951  elongation factor 1-alpha [KO:K03231]
            11414207  uncharacterized protein LOC11414207 [KO:K14291]
            11429115  nuclear cap-binding protein subunit 1 [KO:K12882]
            25487697  nuclear cap-binding protein subunit 2 [KO:K12883]
            11406641  60S ribosomal export protein NMD3 [KO:K07562]
            11426774  60S ribosomal export protein NMD3 [KO:K07562]
            11441100  60S ribosomal export protein NMD3 [KO:K07562]
            11440943  60S ribosomal export protein NMD3 [KO:K07562]
            11441010  60S ribosomal export protein NMD3 [KO:K07562]
            11436295  60S ribosomal export protein NMD3 [KO:K07562]
            11431862  60S ribosomal export protein NMD3 [KO:K07562]
            11423329  60S ribosomal export protein NMD3 [KO:K07562]
            11425835  60S ribosomal export protein NMD3 [KO:K07562]
            11427477  RNA-binding protein Y14A [KO:K12876]
            11423378  protein mago nashi homolog [KO:K12877]
            11421539  protein mago nashi homolog [KO:K12877]
            25488222  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:3.6.4.13]
            11439947  actin cytoskeleton-regulatory complex protein PAN1 [KO:K12875]
            11408942  formin-like protein 5 [KO:K12875]
            25500995  histone deacetylase complex subunit SAP18 [KO:K14324]
            11406805  serine/arginine-rich splicing factor SR45 [KO:K14325]
            11421161  pinin [KO:K13114]
            11406653  THO complex subunit 4D [KO:K12881]
            25492480  THO complex subunit 4A [KO:K12881]
            11446087  THO complex subunit 4B [KO:K12881]
            11422854  regulator of nonsense transcripts UPF2 isoform X1 [KO:K14327]
            11430328  regulator of nonsense transcripts UPF3 isoform X1 [KO:K14328]
            11419393  regulator of nonsense transcripts UPF3 isoform X2 [KO:K14328]
            11431965  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:3.6.4.13]
            25491302  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:3.6.4.13]
            11424505  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:3.6.4.13]
            11427645  serine/arginine repetitive matrix protein 1 [KO:K13171]
            11423581  partner of Y14 and mago [KO:K14294]
            112420425  THO complex subunit 1 [KO:K12878]
            11435146  THO complex subunit 2 [KO:K12879]
            11410144  THO complex subunit 2 [KO:K12879]
            11433389  THO complex subunit 5A [KO:K13174]
            11441838  THO complex subunit 7A [KO:K13176]
            11438034  THO complex subunit 3 [KO:K12880]
REFERENCE   PMID:16777596
  AUTHORS   Tran EJ, Wente SR
  TITLE     Dynamic nuclear pore complexes: life on the edge.
  JOURNAL   Cell 125:1041-53 (2006)
            DOI:10.1016/j.cell.2006.05.027
REFERENCE   PMID:15519698
  AUTHORS   Rodriguez MS, Dargemont C, Stutz F
  TITLE     Nuclear export of RNA.
  JOURNAL   Biol Cell 96:639-55 (2004)
            DOI:10.1016/j.biolcel.2004.04.014
REFERENCE   PMID:18313922
  AUTHORS   Palancade B, Doye V
  TITLE     Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  JOURNAL   Trends Cell Biol 18:174-83 (2008)
            DOI:10.1016/j.tcb.2008.02.001
REFERENCE   PMID:15901496
  AUTHORS   Reed R, Cheng H
  TITLE     TREX, SR proteins and export of mRNA.
  JOURNAL   Curr Opin Cell Biol 17:269-73 (2005)
            DOI:10.1016/j.ceb.2005.04.011
REFERENCE   PMID:16314458
  AUTHORS   Tange TO, Shibuya T, Jurica MS, Moore MJ
  TITLE     Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  JOURNAL   RNA 11:1869-83 (2005)
            DOI:10.1261/rna.2155905
REFERENCE   PMID:28673770
  AUTHORS   Beck M, Schirmacher P, Singer S
  TITLE     Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  JOURNAL   J Hepatol 67:1051-1061 (2017)
            DOI:10.1016/j.jhep.2017.06.021
REL_PATHWAY mtr03015  mRNA surveillance pathway
KO_PATHWAY  ko03013
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