ENTRY       mtr00790                    Pathway
NAME        Folate biosynthesis - Medicago truncatula (barrel medic)
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP mtr00790  Folate biosynthesis
MODULE      mtr_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:mtr00790]
            mtr_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:mtr00790]
DBLINKS     GO: 0046656
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        25500271  GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
            25500428  GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
            11438476  GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
            11429826  uncharacterized protein LOC11429826 [KO:K01113] [EC:3.1.3.1]
            11418039  dihydroneopterin aldolase 2 isoform X2 [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
            25499506  dihydroneopterin aldolase 2 [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
            25499508  dihydroneopterin aldolase 2 [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
            11427230  folate synthesis bifunctional protein, mitochondrial isoform X1 [KO:K13941] [EC:2.7.6.3 2.5.1.15]
            11415341  bifunctional dihydrofolate reductase-thymidylate synthase isoform X1 [KO:K13998] [EC:1.5.1.3 2.1.1.45]
            25495385  bifunctional dihydrofolate reductase-thymidylate synthase isoform X1 [KO:K13998] [EC:1.5.1.3 2.1.1.45]
            11440565  bifunctional dihydrofolate reductase-thymidylate synthase [KO:K13998] [EC:1.5.1.3 2.1.1.45]
            11430199  folylpolyglutamate synthase isoform X1 [KO:K01930] [EC:6.3.2.17]
            11429316  folylpolyglutamate synthase isoform X2 [KO:K01930] [EC:6.3.2.17]
            11408143  folylpolyglutamate synthase [KO:K01930] [EC:6.3.2.17]
            25483316  folylpolyglutamate synthase isoform X1 [KO:K01930] [EC:6.3.2.17]
            25482370  dihydrofolate synthetase isoform X2 [KO:K20457] [EC:6.3.2.12]
            11415421  gamma-glutamyl hydrolase 2 [KO:K01307] [EC:3.4.19.9]
            11416437  gamma-glutamyl hydrolase 2 [KO:K01307] [EC:3.4.19.9]
            11415422  gamma-glutamyl hydrolase 2 [KO:K01307] [EC:3.4.19.9]
            11418835  bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
            11412806  monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic isoform X1 [KO:K14652] [EC:4.1.99.12 3.5.4.25]
            11426139  bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
            11408516  aminodeoxychorismate synthase, chloroplastic isoform X1 [KO:K13950] [EC:2.6.1.85]
            25487305  D-amino-acid transaminase, chloroplastic [KO:K18482] [EC:4.1.3.38]
            25482253  D-amino-acid transaminase, chloroplastic [KO:K18482] [EC:4.1.3.38]
            11421284  (+)-neomenthol dehydrogenase [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            11444609  (+)-neomenthol dehydrogenase [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            11411593  (+)-neomenthol dehydrogenase [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            11415697  pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial isoform X1 [KO:K01724] [EC:4.2.1.96]
            25483198  probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic [KO:K01724] [EC:4.2.1.96]
            25486865  GTP 3',8-cyclase, mitochondrial [KO:K03639] [EC:4.1.99.22]
            25485657  cyclic pyranopterin monophosphate synthase, mitochondrial [KO:K03637] [EC:4.6.1.17]
            11418720  cyclic pyranopterin monophosphate synthase, mitochondrial [KO:K03637] [EC:4.6.1.17]
            25501037  molybdopterin synthase catalytic subunit [KO:K03635] [EC:2.8.1.12]
            11407912  molybdopterin synthase catalytic subunit [KO:K03635] [EC:2.8.1.12]
            11421435  molybdopterin biosynthesis protein CNX1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
            11431360  molybdenum cofactor sulfurase isoform X1 [KO:K15631] [EC:2.8.1.9]
COMPOUND    C00044  GTP
            C00101  Tetrahydrofolate
            C00119  5-Phospho-alpha-D-ribose 1-diphosphate
            C00156  4-Hydroxybenzoate
            C00251  Chorismate
            C00266  Glycolaldehyde
            C00268  Dihydrobiopterin
            C00272  Tetrahydrobiopterin
            C00415  Dihydrofolate
            C00504  Folate
            C00568  4-Aminobenzoate
            C00835  Sepiapterin
            C00921  Dihydropteroate
            C01217  5,6,7,8-Tetrahydromethanopterin
            C01300  6-(Hydroxymethyl)-7,8-dihydropterin
            C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
            C02587  Pyrimidodiazepine
            C02953  7,8-Dihydrobiopterin
            C03541  THF-polyglutamate
            C03684  6-Pyruvoyltetrahydropterin
            C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
            C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
            C04874  7,8-Dihydroneopterin
            C04895  7,8-Dihydroneopterin 3'-triphosphate
            C05922  Formamidopyrimidine nucleoside triphosphate
            C05923  2,5-Diaminopyrimidine nucleoside triphosphate
            C05924  Molybdopterin
            C05925  Dihydroneopterin phosphate
            C05926  Neopterin
            C05927  7,8-Dihydromethanopterin
            C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
            C06313  Biopterin
            C09332  THF-L-glutamate
            C11355  4-Amino-4-deoxychorismate
            C15522  4a-Hydroxytetrahydrobiopterin
            C15996  7-Cyano-7-carbaguanine
            C16675  7-Aminomethyl-7-carbaguanine
            C18237  Molybdoenzyme molybdenum cofactor
            C18239  Precursor Z
            C18802  Tetrahydrosarcinapterin
            C19848  Adenylated molybdopterin
            C19871  Guanylyl molybdenum cofactor
            C20239  6-Carboxy-5,6,7,8-tetrahydropterin
            C20248  7-Carboxy-7-carbaguanine
            C20264  L-threo-Tetrahydrobiopterin
            C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
            C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
            C20566  7,8-Dihydroneopterin 2'-phosphate
            C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
            C21007  5,6,7,8-Tetrahydromonapterin
            C21008  7,8-Dihydromonapterin
            C21065  7,8-Dihydroxanthopterin
            C21094  7,8-Dihydromonapterin 3'-triphosphate
            C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
            C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
            C21485  Cytidylyl molybdenum cofactor
            C21486  Thio-molybdenum cofactor
            C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:19675644
  AUTHORS   Schwarz G, Mendel RR, Ribbe MW
  TITLE     Molybdenum cofactors, enzymes and pathways.
  JOURNAL   Nature 460:839-47 (2009)
            DOI:10.1038/nature08302
REFERENCE   PMID:16632608
  AUTHORS   Hanzelmann P, Schindelin H
  TITLE     Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  JOURNAL   Proc Natl Acad Sci U S A 103:6829-34 (2006)
            DOI:10.1073/pnas.0510711103
REFERENCE   PMID:18092812
  AUTHORS   Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  TITLE     Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  JOURNAL   Biochemistry 47:615-26 (2008)
            DOI:10.1021/bi701734g
REFERENCE   PMID:12571226
  AUTHORS   Wuebbens MM, Rajagopalan KV
  TITLE     Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  JOURNAL   J Biol Chem 278:14523-32 (2003)
            DOI:10.1074/jbc.M300453200
REFERENCE   PMID:21867484
  AUTHORS   Werner ER, Blau N, Thony B
  TITLE     Tetrahydrobiopterin: biochemistry and pathophysiology.
  JOURNAL   Biochem J 438:397-414 (2011)
            DOI:10.1042/BJ20110293
REFERENCE   PMID:12893295
  AUTHORS   Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  TITLE     Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  JOURNAL   Arch Biochem Biophys 416:180-7 (2003)
            DOI:10.1016/S0003-9861(03)00295-9
REFERENCE   PMID:1902669
  AUTHORS   Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  TITLE     Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  JOURNAL   Biochem Biophys Res Commun 175:738-44 (1991)
            DOI:10.1016/0006-291X(91)91628-P
REL_PATHWAY mtr00230  Purine metabolism
            mtr00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            mtr00670  One carbon pool by folate
KO_PATHWAY  ko00790
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