ENTRY       mtr00600                    Pathway
NAME        Sphingolipid metabolism - Medicago truncatula (barrel medic)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP mtr00600  Sphingolipid metabolism
MODULE      mtr_M00100  Sphingosine degradation [PATH:mtr00600]
DBLINKS     GO: 0006665
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        25495905  long chain base biosynthesis protein 2a [KO:K00654] [EC:2.3.1.50]
            11419184  long chain base biosynthesis protein 1 [KO:K00654] [EC:2.3.1.50]
            25489027  long chain base biosynthesis protein 1 [KO:K00654] [EC:2.3.1.50]
            11407105  long chain base biosynthesis protein 1 [KO:K00654] [EC:2.3.1.50]
            25486113  3-dehydrosphinganine reductase TSC10A [KO:K04708] [EC:1.1.1.102]
            11438492  LOW QUALITY PROTEIN: neutral ceramidase 2 [KO:K12349] [EC:3.5.1.23]
            11442755  neutral ceramidase 1 isoform X2 [KO:K12349] [EC:3.5.1.23]
            11437412  neutral ceramidase 2 [KO:K12349] [EC:3.5.1.23]
            11416645  alkaline ceramidase [KO:K04711] [EC:3.5.1.-]
            11441439  alkaline ceramidase [KO:K04711] [EC:3.5.1.-]
            11427221  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
            11420110  sphinganine C4-monooxygenase 1 [KO:K04713] [EC:1.14.18.5]
            25485019  very-long-chain aldehyde decarbonylase GL1-9 [KO:K04713] [EC:1.14.18.5]
            11409122  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
            25485929  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
            11437795  sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
            25494378  non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
            11423130  non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
            11444548  beta-galactosidase isoform X2 [KO:K01190] [EC:3.2.1.23]
            11427149  beta-galactosidase 17 isoform X1 [KO:K12309] [EC:3.2.1.23]
            25498854  alpha-galactosidase 1 [KO:K07407] [EC:3.2.1.22]
            25498855  alpha-galactosidase 1 [KO:K07407] [EC:3.2.1.22]
            25496906  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
            25496908  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
            25489841  alpha-galactosidase 3 [KO:K07407] [EC:3.2.1.22]
            11417650  alpha-galactosidase isoform X2 [KO:K07407] [EC:3.2.1.22]
            25484539  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
            25484541  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
            25485726  beta-hexosaminidase 1 [KO:K12373] [EC:3.2.1.52]
            11444497  beta-hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
            25497697  beta-hexosaminidase 1 [KO:K12373] [EC:3.2.1.52]
            25491715  prosaposin [KO:K12382]
            11433621  prosaposin [KO:K12382]
COMPOUND    C00065  L-Serine
            C00154  Palmitoyl-CoA
            C00195  N-Acylsphingosine
            C00319  Sphingosine
            C00346  Ethanolamine phosphate
            C00550  Sphingomyelin
            C00836  Sphinganine
            C01120  Sphinganine 1-phosphate
            C01190  Glucosylceramide
            C01290  Lactosylceramide
            C01747  Psychosine
            C02686  Galactosylceramide
            C02934  3-Dehydrosphinganine
            C02960  Ceramide 1-phosphate
            C03405  Lactosylceramide sulfate
            C03640  Sphingosyl-phosphocholine
            C05681  Ceramide 2-aminoethylphosphonate
            C06062  Ceramide phosphoethanolamine
            C06124  Sphingosine 1-phosphate
            C06125  Sulfatide
            C06126  Digalactosylceramide
            C06127  Digalactosylceramide sulfate
            C06128  GM4
            C12126  Dihydroceramide
            C12144  Phytosphingosine
            C12145  Phytoceramide
            C22467  Gangliotriaosylceramide-II3 sulfate
REFERENCE   PMID:12011104
  AUTHORS   Merrill AH Jr.
  TITLE     De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  JOURNAL   J Biol Chem 277:25843-6 (2002)
            DOI:10.1074/jbc.R200009200
REFERENCE   PMID:10652340
  AUTHORS   Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  TITLE     Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  JOURNAL   J Biol Chem 275:3462-8 (2000)
            DOI:10.1074/jbc.275.5.3462
REFERENCE   PMID:11305904
  AUTHORS   Hannun YA, Luberto C, Argraves KM.
  TITLE     Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  JOURNAL   Biochemistry 40:4893-903 (2001)
            DOI:10.1021/bi002836k
REFERENCE   PMID:1495423
  AUTHORS   Merrill AH Jr, Wang E.
  TITLE     Enzymes of ceramide biosynthesis.
  JOURNAL   Methods Enzymol 209:427-37 (1992)
            DOI:10.1016/0076-6879(92)09053-6
REFERENCE   PMID:8457204
  AUTHORS   Hirschberg K, Rodger J, Futerman AH.
  TITLE     The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  JOURNAL   Biochem J 290 ( Pt 3):751-7 (1993)
            DOI:10.1042/bj2900751
REFERENCE   PMID:10366774
  AUTHORS   Dickson RC, Lester RL.
  TITLE     Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  JOURNAL   Biochim Biophys Acta 1438:305-21 (1999)
            DOI:10.1016/S1388-1981(99)00068-2
REL_PATHWAY mtr00260  Glycine, serine and threonine metabolism
            mtr00601  Glycosphingolipid biosynthesis - lacto and neolacto series
            mtr00603  Glycosphingolipid biosynthesis - globo and isoglobo series
            mtr00604  Glycosphingolipid biosynthesis - ganglio series
KO_PATHWAY  ko00600
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