ENTRY       mtr00450                    Pathway
NAME        Selenocompound metabolism - Medicago truncatula (barrel medic)
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP mtr00450  Selenocompound metabolism
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11427680  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
            11406997  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
            25483994  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
            11442193  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 isoform X1 [KO:K00549] [EC:2.1.1.14]
            11439549  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
            25495847  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
            11435964  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
            25484569  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
            11442477  cysteine desulfurase 1, chloroplastic [KO:K11717] [EC:2.8.1.7 4.4.1.16]
            11434316  methionine S-methyltransferase isoform X2 [KO:K08247] [EC:2.1.1.12]
            11407046  thioredoxin reductase NTRB [KO:K00384] [EC:1.8.1.9]
            25483453  NADPH-dependent thioredoxin reductase 3 [KO:K00384] [EC:1.8.1.9]
            25495488  ATP sulfurylase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
            25485115  ATP sulfurylase 1, chloroplastic [KO:K13811] [EC:2.7.7.4 2.7.1.25]
            25485698  methionine--tRNA ligase, chloroplastic/mitochondrial [KO:K01874] [EC:6.1.1.10]
            11441226  probable methionine--tRNA ligase [KO:K01874] [EC:6.1.1.10]
            11422324  probable methionine--tRNA ligase [KO:K01874] [EC:6.1.1.10]
COMPOUND    C00017  Protein
            C00041  L-Alanine
            C01528  Hydrogen selenide
            C02535  Dimethyl selenide
            C05172  Selenophosphoric acid
            C05335  L-Selenomethionine
            C05336  Selenomethionyl-tRNA(Met)
            C05684  Selenite
            C05686  Adenylylselenate
            C05688  L-Selenocysteine
            C05689  Se-Methyl-L-selenocysteine
            C05690  Se-Methylselenomethionine
            C05695  gamma-Glutamyl-Se-methylselenocysteine
            C05697  Selenate
            C05698  Selenohomocysteine
            C05699  L-Selenocystathionine
            C05703  Methaneselenol
            C06481  L-Seryl-tRNA(Sec)
            C06482  L-Selenocysteinyl-tRNA(Sec)
            C16638  O-Phosphoseryl-tRNA(Sec)
            C18870  Selenodiglutathione
            C18871  Glutathioselenol
            C18872  Trimethylselenonium
            C18893  1-Methylseleno-N-acetyl-D-galactosamine
            C18902  Methylselenic acid
            C18904  Methylselenopyruvate
            C18905  Methylselenocysteine Se-oxide
REFERENCE   PMID:21190829
  AUTHORS   Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  TITLE     Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  JOURNAL   J Nutr Biochem 22:945-55 (2011)
            DOI:10.1016/j.jnutbio.2010.08.006
REFERENCE   PMID:19051051
  AUTHORS   McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  TITLE     Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  JOURNAL   Transgenic Res 18:407-24 (2009)
            DOI:10.1007/s11248-008-9233-0
REFERENCE   PMID:20383543
  AUTHORS   Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  TITLE     Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  JOURNAL   Amino Acids 41:29-41 (2011)
            DOI:10.1007/s00726-010-0578-3
REFERENCE   PMID:17451884
  AUTHORS   Suzuki KT, Kurasaki K, Suzuki N
  TITLE     Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  JOURNAL   Biochim Biophys Acta 1770:1053-61 (2007)
            DOI:10.1016/j.bbagen.2007.03.007
REFERENCE   PMID:11782468
  AUTHORS   Gromer S, Gross JH
  TITLE     Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  JOURNAL   J Biol Chem 277:9701-6 (2002)
            DOI:10.1074/jbc.M109234200
KO_PATHWAY  ko00450
///
