ENTRY       mtr00290                    Pathway
NAME        Valine, leucine and isoleucine biosynthesis - Medicago truncatula (barrel medic)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP mtr00290  Valine, leucine and isoleucine biosynthesis
MODULE      mtr_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mtr00290]
            mtr_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mtr00290]
            mtr_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mtr00290]
DBLINKS     GO: 0009097 0009098 0009099
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11433265  threonine dehydratase biosynthetic, chloroplastic isoform X2 [KO:K01754] [EC:4.3.1.19]
            11432785  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
            11434985  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
            25491331  3-isopropylmalate dehydratase small subunit 1 [KO:K01704] [EC:4.2.1.33 4.2.1.35]
            11433087  3-isopropylmalate dehydrogenase, chloroplastic [KO:K00052] [EC:1.1.1.85]
            11421182  acetolactate synthase 3, chloroplastic [KO:K01652] [EC:2.2.1.6]
            11407998  acetolactate synthase 3, chloroplastic [KO:K01652] [EC:2.2.1.6]
            11425585  acetolactate synthase, chloroplastic [KO:K01652] [EC:2.2.1.6]
            11426593  acetolactate synthase small subunit 2, chloroplastic [KO:K01653] [EC:2.2.1.6]
            11418347  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
            11422645  dihydroxy-acid dehydratase, chloroplastic [KO:K01687] [EC:4.2.1.9]
            11408371  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            11410393  branched-chain-amino-acid aminotransferase 6 [KO:K00826] [EC:2.6.1.42]
            11434910  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            25490006  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            11445801  2-isopropylmalate synthase 2, chloroplastic isoform X1 [KO:K01649] [EC:2.3.3.13]
            25497889  probable 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00109  2-Oxobutanoate
            C00123  L-Leucine
            C00141  3-Methyl-2-oxobutanoic acid
            C00183  L-Valine
            C00188  L-Threonine
            C00233  4-Methyl-2-oxopentanoate
            C00407  L-Isoleucine
            C00671  (S)-3-Methyl-2-oxopentanoic acid
            C02226  2-Methylmaleate
            C02504  alpha-Isopropylmalate
            C02612  (R)-2-Methylmalate
            C02631  2-Isopropylmaleate
            C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
            C04236  (2S)-2-Isopropyl-3-oxosuccinate
            C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
            C04411  (2R,3S)-3-Isopropylmalate
            C06006  (S)-2-Aceto-2-hydroxybutanoate
            C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
            C06010  (S)-2-Acetolactate
            C06032  D-erythro-3-Methylmalate
            C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
REFERENCE   PMID:15292141
  AUTHORS   Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  TITLE     Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  JOURNAL   J Bacteriol 186:5400-9 (2004)
            DOI:10.1128/JB.186.16.5400-5409.2004
REL_PATHWAY mtr00260  Glycine, serine and threonine metabolism
            mtr00280  Valine, leucine and isoleucine degradation
            mtr00620  Pyruvate metabolism
KO_PATHWAY  ko00290
///
