ENTRY       mtr00280                    Pathway
NAME        Valine, leucine and isoleucine degradation - Medicago truncatula (barrel medic)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP mtr00280  Valine, leucine and isoleucine degradation
MODULE      mtr_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:mtr00280]
DBLINKS     GO: 0006550 0006552 0006574
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11408371  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            11410393  branched-chain-amino-acid aminotransferase 6 [KO:K00826] [EC:2.6.1.42]
            11434910  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            25490006  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
            11424992  2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial [KO:K00166] [EC:1.2.4.4]
            25489740  2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial [KO:K00166] [EC:1.2.4.4]
            11428104  2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial [KO:K00167] [EC:1.2.4.4]
            25494077  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
            11408806  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
            11422305  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
            25494137  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
            25488070  probable acyl-CoA dehydrogenase IBR3 [KO:K00249] [EC:1.3.8.7]
            11412098  isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
            11418333  probable enoyl-CoA hydratase 1, peroxisomal [KO:K01692] [EC:4.2.1.17]
            11417930  3-ketoacyl CoA thiolase 1, peroxisomal [KO:K07513] [EC:2.3.1.16]
            25483109  3-ketoacyl-CoA thiolase 2, peroxisomal [KO:K07513] [EC:2.3.1.16]
            11423313  3-hydroxyisobutyryl-CoA hydrolase-like protein 1, mitochondrial [KO:K05605] [EC:3.1.2.4]
            11410121  3-hydroxyisobutyryl-CoA hydrolase-like protein 3, mitochondrial isoform X2 [KO:K05605] [EC:3.1.2.4]
            25500243  3-hydroxyisobutyryl-CoA hydrolase 1 [KO:K05605] [EC:3.1.2.4]
            25488912  3-hydroxyisobutyryl-CoA hydrolase-like protein 5 [KO:K05605] [EC:3.1.2.4]
            11427294  3-hydroxyisobutyryl-CoA hydrolase-like protein 2, mitochondrial [KO:K05605] [EC:3.1.2.4]
            11436146  probable 3-hydroxyisobutyrate dehydrogenase-like 2, mitochondrial [KO:K00020] [EC:1.1.1.31]
            11412195  probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial [KO:K00020] [EC:1.1.1.31]
            11408758  probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial [KO:K23146] [EC:1.1.1.31 1.1.1.59]
            11430354  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial isoform X1 [KO:K00140] [EC:1.2.1.18 1.2.1.27]
            11410416  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
            25501312  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
            11413753  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
            11433409  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            11441005  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            11411505  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            11443205  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
            25492569  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            25489543  aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
            25482459  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
            11437741  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            25491411  malonate--CoA ligase isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
            25491371  malonate--CoA ligase [KO:K18660] [EC:6.2.1.76 6.2.1.-]
            11442560  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            25490994  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            11433125  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            11431272  methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
            11446438  methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
            11406894  probable enoyl-CoA hydratase 2, mitochondrial [KO:K05607] [EC:4.2.1.18]
            11406357  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            11413302  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            25481093  acetyl-CoA acetyltransferase, cytosolic 1 [KO:K00626] [EC:2.3.1.9]
            25494326  LOW QUALITY PROTEIN: acetyl-CoA acetyltransferase, cytosolic 1 [KO:K00626] [EC:2.3.1.9]
            11424070  acetyl-CoA acetyltransferase, cytosolic 1 [KO:K00626] [EC:2.3.1.9]
            11429131  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
            11438999  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
COMPOUND    C00024  Acetyl-CoA
            C00068  Thiamin diphosphate
            C00091  Succinyl-CoA
            C00100  Propanoyl-CoA
            C00123  L-Leucine
            C00141  3-Methyl-2-oxobutanoic acid
            C00164  Acetoacetate
            C00183  L-Valine
            C00233  4-Methyl-2-oxopentanoate
            C00332  Acetoacetyl-CoA
            C00349  2-Methyl-3-oxopropanoate
            C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
            C00407  L-Isoleucine
            C00630  2-Methylpropanoyl-CoA
            C00671  (S)-3-Methyl-2-oxopentanoic acid
            C00683  (S)-Methylmalonyl-CoA
            C01205  (R)-3-Amino-2-methylpropanoate
            C01213  (R)-Methylmalonyl-CoA
            C02170  Methylmalonate
            C02939  3-Methylbutanoyl-CoA
            C03069  3-Methylcrotonyl-CoA
            C03231  3-Methylglutaconyl-CoA
            C03284  L-3-Aminoisobutanoate
            C03344  2-Methylacetoacetyl-CoA
            C03345  2-Methylbut-2-enoyl-CoA
            C03460  2-Methylprop-2-enoyl-CoA
            C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
            C05996  Branched chain fatty acid
            C05998  3-Hydroxyisovaleryl-CoA
            C06000  (S)-3-Hydroxyisobutyryl-CoA
            C06001  (S)-3-Hydroxyisobutyrate
            C06002  (S)-Methylmalonate semialdehyde
            C15972  Enzyme N6-(lipoyl)lysine
            C15973  Enzyme N6-(dihydrolipoyl)lysine
            C15974  3-Methyl-1-hydroxybutyl-ThPP
            C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
            C15976  2-Methyl-1-hydroxypropyl-ThPP
            C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
            C15978  2-Methyl-1-hydroxybutyl-ThPP
            C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
            C15980  (S)-2-Methylbutanoyl-CoA
            C20827  3-Hydroxyisovalerate
REL_PATHWAY mtr00020  Citrate cycle (TCA cycle)
            mtr00240  Pyrimidine metabolism
            mtr00290  Valine, leucine and isoleucine biosynthesis
            mtr00640  Propanoate metabolism
            mtr00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko00280
///
