ENTRY       mtr00061                    Pathway
NAME        Fatty acid biosynthesis - Medicago truncatula (barrel medic)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP mtr00061  Fatty acid biosynthesis
MODULE      mtr_M00082  Fatty acid biosynthesis, initiation [PATH:mtr00061]
            mtr_M00083  Fatty acid biosynthesis, elongation [PATH:mtr00061]
            mtr_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:mtr00061]
DBLINKS     GO: 0006633
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        25489411  LOW QUALITY PROTEIN: acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            25489412  acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            25498718  acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic isoform X1 [KO:K01962] [EC:6.4.1.2 2.1.3.15]
            11414487  biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic [KO:K02160]
            11420469  biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic [KO:K02160]
            11442359  biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic [KO:K02160]
            11442175  biotin carboxylase 2, chloroplastic [KO:K01961] [EC:6.4.1.2 6.3.4.14]
            25491411  malonate--CoA ligase isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
            25491371  malonate--CoA ligase [KO:K18660] [EC:6.2.1.76 6.2.1.-]
            11405229  malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
            11423734  3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic [KO:K00648] [EC:2.3.1.180]
            25487983  3-oxoacyl-[acyl-carrier-protein] synthase 3 A, chloroplastic [KO:K00648] [EC:2.3.1.180]
            25502219  3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic [KO:K09458] [EC:2.3.1.179]
            11411851  LOW QUALITY PROTEIN: 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic [KO:K09458] [EC:2.3.1.179]
            11446734  3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic [KO:K09458] [EC:2.3.1.179]
            25486549  3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic [KO:K09458] [EC:2.3.1.179]
            25484188  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [KO:K09458] [EC:2.3.1.179]
            25485150  3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic [KO:K09458] [EC:2.3.1.179]
            25484124  NADPH-dependent aldehyde reductase-like protein, chloroplastic [KO:K00059] [EC:1.1.1.100]
            11440405  3-oxoacyl-[acyl-carrier-protein] reductase 4 [KO:K00059] [EC:1.1.1.100]
            25499093  NADPH-dependent aldehyde reductase-like protein, chloroplastic [KO:K00059] [EC:1.1.1.100]
            25499094  NADPH-dependent aldehyde reductase-like protein, chloroplastic [KO:K00059] [EC:1.1.1.100]
            11419786  3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
            25493282  3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
            11446620  enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic-like [KO:K00208] [EC:1.3.1.9 1.3.1.10]
            25498181  enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic [KO:K00208] [EC:1.3.1.9 1.3.1.10]
            11422155  enoyl-[acyl-carrier-protein] reductase, mitochondrial [KO:K07512] [EC:1.3.1.- 1.3.1.38]
            112419006  palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21]
            11419965  palmitoyl-acyl carrier protein thioesterase, chloroplastic [KO:K10781] [EC:3.1.2.14 3.1.2.21]
            11445423  palmitoyl-acyl carrier protein thioesterase, chloroplastic [KO:K10781] [EC:3.1.2.14 3.1.2.21]
            25498271  oleoyl-acyl carrier protein thioesterase 1, chloroplastic [KO:K10782] [EC:3.1.2.14]
            11415358  stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            11422210  stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            11413317  stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            11446234  stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            11413449  stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            25489755  stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            25482407  stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
            11410333  probable acyl-activating enzyme 16, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11436555  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
            11429070  probable acyl-activating enzyme 16, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11438515  probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3]
            11414801  LOW QUALITY PROTEIN: long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
            25502179  long chain acyl-CoA synthetase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
            11419994  long chain acyl-CoA synthetase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
            25482683  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            25492683  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            11426097  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            11437197  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            11409239  long chain acyl-CoA synthetase 9, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            11422879  long chain acyl-CoA synthetase 6, peroxisomal [KO:K01897] [EC:6.2.1.3]
            11427214  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
COMPOUND    C00024  Acetyl-CoA
            C00083  Malonyl-CoA
            C00154  Palmitoyl-CoA
            C00173  Acyl-[acyl-carrier protein]
            C00229  Acyl-carrier protein
            C00249  Hexadecanoic acid
            C00383  Malonate
            C00638  Long-chain fatty acid
            C00685  3-Oxoacyl-[acyl-carrier protein]
            C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
            C00712  (9Z)-Octadecenoic acid
            C01203  Oleoyl-[acyl-carrier protein]
            C01209  Malonyl-[acyl-carrier protein]
            C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
            C01530  Octadecanoic acid
            C01571  Decanoic acid
            C02679  Dodecanoic acid
            C02843  Long-chain acyl-CoA
            C03939  Acetyl-[acyl-carrier protein]
            C04088  Octadecanoyl-[acyl-carrier protein]
            C04180  cis-Dec-3-enoyl-[acp]
            C04246  But-2-enoyl-[acyl-carrier protein]
            C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
            C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
            C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
            C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
            C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
            C05223  Dodecanoyl-[acyl-carrier protein]
            C05744  Acetoacetyl-[acp]
            C05745  Butyryl-[acp]
            C05746  3-Oxohexanoyl-[acp]
            C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
            C05748  trans-Hex-2-enoyl-[acp]
            C05749  Hexanoyl-[acp]
            C05750  3-Oxooctanoyl-[acp]
            C05751  trans-Oct-2-enoyl-[acp]
            C05752  Octanoyl-[acp]
            C05753  3-Oxodecanoyl-[acp]
            C05754  trans-Dec-2-enoyl-[acp]
            C05755  Decanoyl-[acp]
            C05756  3-Oxododecanoyl-[acp]
            C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
            C05758  trans-Dodec-2-enoyl-[acp]
            C05759  3-Oxotetradecanoyl-[acp]
            C05760  trans-Tetradec-2-enoyl-[acp]
            C05761  Tetradecanoyl-[acp]
            C05762  3-Oxohexadecanoyl-[acp]
            C05763  trans-Hexadec-2-enoyl-[acp]
            C05764  Hexadecanoyl-[acp]
            C06423  Octanoic acid
            C06424  Tetradecanoic acid
            C08362  (9Z)-Hexadecenoic acid
            C16219  3-Oxostearoyl-[acp]
            C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
            C16221  (2E)-Octadecenoyl-[acp]
            C16520  Hexadecenoyl-[acyl-carrier protein]
            C20683  Long-chain acyl-[acyl-carrier protein]
            C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
REFERENCE   PMID:12061798
  AUTHORS   Salas JJ, Ohlrogge JB.
  TITLE     Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  JOURNAL   Arch Biochem Biophys 403:25-34 (2002)
            DOI:10.1016/S0003-9861(02)00017-6
REFERENCE   PMID:12518017
  AUTHORS   Zhang YM, Marrakchi H, White SW, Rock CO.
  TITLE     The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  JOURNAL   J Lipid Res 44:1-10 (2003)
            DOI:10.1194/jlr.R200016-JLR200
REFERENCE   PMID:11337402
  AUTHORS   Voelker T, Kinney AJ.
  TITLE     VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  JOURNAL   Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
            DOI:10.1146/annurev.arplant.52.1.335
REFERENCE   PMID:17573542
  AUTHORS   Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  TITLE     Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  JOURNAL   Plant Physiol 144:1827-42 (2007)
            DOI:10.1104/pp.107.096172
REFERENCE   PMID:30201289
  AUTHORS   Bowman CE, Wolfgang MJ
  TITLE     Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  JOURNAL   Adv Biol Regul 71:34-40 (2019)
            DOI:10.1016/j.jbior.2018.09.002
REFERENCE   PMID:25203508
  AUTHORS   Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  TITLE     Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  JOURNAL   Nat Commun 5:4805 (2014)
            DOI:10.1038/ncomms5805
REFERENCE   PMID:19686777
  AUTHORS   Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  TITLE     Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  JOURNAL   Prog Lipid Res 49:27-45 (2010)
            DOI:10.1016/j.plipres.2009.08.001
REFERENCE   PMID:27553474
  AUTHORS   Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  TITLE     Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
            DOI:10.1016/j.bbalip.2016.08.011
REL_PATHWAY mtr00020  Citrate cycle (TCA cycle)
            mtr00062  Fatty acid elongation
            mtr00071  Fatty acid degradation
            mtr00410  beta-Alanine metabolism
            mtr00561  Glycerolipid metabolism
            mtr00564  Glycerophospholipid metabolism
            mtr00620  Pyruvate metabolism
            mtr00785  Lipoic acid metabolism
KO_PATHWAY  ko00061
///
