ENTRY       mtr00030                    Pathway
NAME        Pentose phosphate pathway - Medicago truncatula (barrel medic)
DESCRIPTION The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP mtr00030  Pentose phosphate pathway
MODULE      mtr_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:mtr00030]
            mtr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtr00030]
            mtr_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:mtr00030]
            mtr_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:mtr00030]
DBLINKS     GO: 0006098
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11426025  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
            11434432  glucose-6-phosphate isomerase, cytosolic 1 [KO:K01810] [EC:5.3.1.9]
            11424460  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            120577280  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            25481550  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            25495714  glucose-6-phosphate 1-dehydrogenase 5, cytoplasmic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            11440318  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            11427023  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            11437926  6-phosphogluconolactonase 3, chloroplastic [KO:K01057] [EC:3.1.1.31]
            11420516  probable 6-phosphogluconolactonase 1 isoform X1 [KO:K01057] [EC:3.1.1.31]
            25482355  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
            25482356  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
            25502143  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            25497623  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            25493830  ribulose-phosphate 3-epimerase, chloroplastic [KO:K01783] [EC:5.1.3.1]
            25497874  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:5.1.3.1]
            25490535  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:5.1.3.1]
            11424367  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
            11423341  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
            25501975  transaldolase [KO:K00616] [EC:2.2.1.2]
            11410681  transaldolase isoform X1 [KO:K00616] [EC:2.2.1.2]
            11406940  transaldolase [KO:K00616] [EC:2.2.1.2]
            11421390  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
            11410188  probable ribose-5-phosphate isomerase 4, chloroplastic [KO:K01807] [EC:5.3.1.6]
            11409058  probable ribose-5-phosphate isomerase 1 [KO:K01807] [EC:5.3.1.6]
            25487162  ribokinase [KO:K00852] [EC:2.7.1.15]
            11413693  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
            11414670  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
            25500166  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
            11415474  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
            11436321  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
            11423304  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
            11445286  gluconokinase [KO:K00851] [EC:2.7.1.12]
            120576861  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
            11445395  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            25494828  fructose-bisphosphate aldolase, cytoplasmic isozyme [KO:K01623] [EC:4.1.2.13]
            11440200  LOW QUALITY PROTEIN: fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            25492390  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            11433706  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:4.1.2.13]
            25483885  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
            25485453  fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:4.1.2.13]
            11430747  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            25498664  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
            11416430  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
            25496103  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            11423706  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
            11430664  ATP-dependent 6-phosphofructokinase 7 [KO:K00850] [EC:2.7.1.11]
            11415742  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
            11405809  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
            25494344  LOW QUALITY PROTEIN: ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
            25490151  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
            11438579  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
            11410489  ATP-dependent 6-phosphofructokinase 4, chloroplastic isoform X1 [KO:K00850] [EC:2.7.1.11]
            11445901  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
            11434359  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
            11439570  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
COMPOUND    C00022  Pyruvate
            C00031  D-Glucose
            C00117  D-Ribose 5-phosphate
            C00118  D-Glyceraldehyde 3-phosphate
            C00119  5-Phospho-alpha-D-ribose 1-diphosphate
            C00121  D-Ribose
            C00197  3-Phospho-D-glycerate
            C00198  D-Glucono-1,5-lactone
            C00199  D-Ribulose 5-phosphate
            C00204  2-Dehydro-3-deoxy-D-gluconate
            C00221  beta-D-Glucose
            C00231  D-Xylulose 5-phosphate
            C00257  D-Gluconic acid
            C00258  D-Glycerate
            C00279  D-Erythrose 4-phosphate
            C00345  6-Phospho-D-gluconate
            C00577  D-Glyceraldehyde
            C00620  alpha-D-Ribose 1-phosphate
            C00631  2-Phospho-D-glycerate
            C00668  alpha-D-Glucose 6-phosphate
            C00672  2-Deoxy-D-ribose 1-phosphate
            C00673  2-Deoxy-D-ribose 5-phosphate
            C01151  D-Ribose 1,5-bisphosphate
            C01172  beta-D-Glucose 6-phosphate
            C01182  D-Ribulose 1,5-bisphosphate
            C01218  6-Phospho-2-dehydro-D-gluconate
            C01236  D-Glucono-1,5-lactone 6-phosphate
            C01801  Deoxyribose
            C03752  2-Amino-2-deoxy-D-gluconate
            C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
            C05345  beta-D-Fructose 6-phosphate
            C05378  beta-D-Fructose 1,6-bisphosphate
            C05382  Sedoheptulose 7-phosphate
            C06019  D-arabino-Hex-3-ulose 6-phosphate
            C06473  2-Keto-D-gluconic acid
            C20589  D-Glucosaminate-6-phosphate
REFERENCE   
  AUTHORS   Nishizuka Y (ed).
  TITLE     [Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1980)
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   
  AUTHORS   Michal G.
  TITLE     Biochemical Pathways
  JOURNAL   Wiley (1999)
REFERENCE   PMID:12700258
  AUTHORS   Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  TITLE     Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  JOURNAL   J Bacteriol 185:2793-801 (2003)
            DOI:10.1128/JB.185.9.2793-2801.2003
REFERENCE   PMID:16788179
  AUTHORS   Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  TITLE     The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  JOURNAL   J Bacteriol 188:4698-704 (2006)
            DOI:10.1128/JB.00492-06
REFERENCE   PMID:16428816
  AUTHORS   Kato N, Yurimoto H, Thauer RK
  TITLE     The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  JOURNAL   Biosci Biotechnol Biochem 70:10-21 (2006)
            DOI:10.1271/bbb.70.10
REFERENCE   PMID:23279921
  AUTHORS   Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  TITLE     Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  JOURNAL   FEBS J 280:1126-38 (2013)
            DOI:10.1111/febs.12106
REFERENCE   PMID:16458304
  AUTHORS   Reher M, Schonheit P
  TITLE     Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  JOURNAL   FEBS Lett 580:1198-204 (2006)
            DOI:10.1016/j.febslet.2006.01.029
REFERENCE   PMID:20023024
  AUTHORS   Reher M, Fuhrer T, Bott M, Schonheit P
  TITLE     The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  JOURNAL   J Bacteriol 192:964-74 (2010)
            DOI:10.1128/JB.01281-09
REL_PATHWAY mtr00010  Glycolysis / Gluconeogenesis
            mtr00040  Pentose and glucuronate interconversions
            mtr00052  Galactose metabolism
            mtr00230  Purine metabolism
            mtr00240  Pyrimidine metabolism
            mtr00340  Histidine metabolism
            mtr00630  Glyoxylate and dicarboxylate metabolism
            mtr00750  Vitamin B6 metabolism
KO_PATHWAY  ko00030
///
