ENTRY       mtr00010                    Pathway
NAME        Glycolysis / Gluconeogenesis - Medicago truncatula (barrel medic)
DESCRIPTION Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP mtr00010  Glycolysis / Gluconeogenesis
MODULE      mtr_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:mtr00010]
            mtr_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mtr00010]
            mtr_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mtr00010]
            mtr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mtr00010]
DBLINKS     GO: 0006096 0006094
ORGANISM    Medicago truncatula (barrel medic) [GN:mtr]
GENE        11421234  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
            11408101  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
            25496982  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
            11426910  hexokinase-3 [KO:K00844] [EC:2.7.1.1]
            11421510  hexokinase-2, chloroplastic [KO:K00844] [EC:2.7.1.1]
            11426025  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
            11434432  glucose-6-phosphate isomerase, cytosolic 1 [KO:K01810] [EC:5.3.1.9]
            11423706  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
            11430664  ATP-dependent 6-phosphofructokinase 7 [KO:K00850] [EC:2.7.1.11]
            11415742  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
            11405809  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
            25494344  LOW QUALITY PROTEIN: ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
            25490151  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
            11438579  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
            11410489  ATP-dependent 6-phosphofructokinase 4, chloroplastic isoform X1 [KO:K00850] [EC:2.7.1.11]
            11445901  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
            11434359  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
            11439570  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
            11430747  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            25498664  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
            11416430  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
            25496103  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
            120576861  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
            11445395  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            25494828  fructose-bisphosphate aldolase, cytoplasmic isozyme [KO:K01623] [EC:4.1.2.13]
            11440200  LOW QUALITY PROTEIN: fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            25492390  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
            11433706  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:4.1.2.13]
            25483885  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
            25485453  fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:4.1.2.13]
            25499344  triosephosphate isomerase, chloroplastic [KO:K01803] [EC:5.3.1.1]
            25487887  triosephosphate isomerase, cytosolic [KO:K01803] [EC:5.3.1.1]
            11425454  glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic [KO:K00134] [EC:1.2.1.12]
            11441068  glyceraldehyde-3-phosphate dehydrogenase, cytosolic isoform X2 [KO:K00134] [EC:1.2.1.12]
            25495698  glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic [KO:K00134] [EC:1.2.1.12]
            11407960  glyceraldehyde-3-phosphate dehydrogenase, cytosolic [KO:K00134] [EC:1.2.1.12]
            11421966  phosphoglycerate kinase 3, cytosolic [KO:K00927] [EC:2.7.2.3]
            11424739  phosphoglycerate kinase, cytosolic [KO:K00927] [EC:2.7.2.3]
            11441786  phosphoglycerate kinase, cytosolic [KO:K00927] [EC:2.7.2.3]
            25495634  phosphoglycerate kinase isoform X1 [KO:K00927] [EC:2.7.2.3]
            11442350  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 isoform X2 [KO:K01834] [EC:5.4.2.11]
            25489422  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
            11417969  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
            11406747  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
            11435852  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            11446699  enolase [KO:K01689] [EC:4.2.1.11]
            25499389  enolase [KO:K01689] [EC:4.2.1.11]
            11442340  cytosolic enolase 3 [KO:K01689] [EC:4.2.1.11]
            25486813  enolase 1, chloroplastic [KO:K01689] [EC:4.2.1.11]
            25499373  pyruvate kinase 1, cytosolic isoform X2 [KO:K00873] [EC:2.7.1.40]
            25495079  pyruvate kinase, cytosolic isozyme [KO:K00873] [EC:2.7.1.40]
            25496020  plastidial pyruvate kinase 2 [KO:K00873] [EC:2.7.1.40]
            11440906  pyruvate kinase, cytosolic isozyme-like [KO:K00873] [EC:2.7.1.40]
            11446186  pyruvate kinase, cytosolic isozyme [KO:K00873] [EC:2.7.1.40]
            11435634  pyruvate kinase isozyme G, chloroplastic isoform X1 [KO:K00873] [EC:2.7.1.40]
            11429725  pyruvate kinase 1, cytosolic [KO:K00873] [EC:2.7.1.40]
            11419730  plastidial pyruvate kinase 2 [KO:K00873] [EC:2.7.1.40]
            11431881  pyruvate kinase, cytosolic isozyme [KO:K00873] [EC:2.7.1.40]
            25484474  pyruvate kinase isozyme A, chloroplastic [KO:K00873] [EC:2.7.1.40]
            25484886  pyruvate kinase 1, cytosolic [KO:K00873] [EC:2.7.1.40]
            25485305  pyruvate kinase isozyme A, chloroplastic [KO:K00873] [EC:2.7.1.40]
            120580162  pyruvate, phosphate dikinase 2-like [KO:K01006] [EC:2.7.9.1]
            11417770  pyruvate, phosphate dikinase, chloroplastic [KO:K01006] [EC:2.7.9.1]
            11416624  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
            25500614  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
            11414398  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
            11411402  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
            120577439  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
            11442185  pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
            11423972  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
            25484885  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
            25484957  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
            25485515  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
            11408806  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
            11422305  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
            25494137  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
            11406365  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
            11427630  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
            11420638  pyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
            11439310  pyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
            11426427  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
            11413068  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
            11436410  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
            11415692  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
            25479300  8-hydroxygeraniol oxidoreductase isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11435949  alcohol dehydrogenase-like 7 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11435950  alcohol dehydrogenase-like 7 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11431241  alcohol dehydrogenase-like 2 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11432074  8-hydroxygeraniol oxidoreductase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11435196  alcohol dehydrogenase-like 7 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            25484194  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11425223  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            11422713  alcohol dehydrogenase 1 isoform X2 [KO:K18857] [EC:1.1.1.1]
            11411514  alcohol dehydrogenase 1 [KO:K18857] [EC:1.1.1.1]
            25489766  alcohol dehydrogenase 1 [KO:K18857] [EC:1.1.1.1]
            11422221  alcohol dehydrogenase-like 6 [KO:K00001] [EC:1.1.1.1]
            11408667  alcohol dehydrogenase-like 4 [KO:K00001] [EC:1.1.1.1]
            25501526  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            25501528  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            25498586  NADPH-dependent aldo-keto reductase, chloroplastic isoform X1 [KO:K00002] [EC:1.1.1.2]
            11411585  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            11419261  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
            11428103  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
            11407540  aldose reductase [KO:K00002] [EC:1.1.1.2]
            25501312  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
            11413753  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
            11433409  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            11441005  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            11411505  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            11443205  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
            25492569  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            25489543  aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
            25482459  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
            11437741  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            11437257  acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal [KO:K01895] [EC:6.2.1.1]
            11422889  acetate/butyrate--CoA ligase AAE7, peroxisomal [KO:K01913] [EC:6.2.1.1 6.2.1.2]
            25486581  acetate/butyrate--CoA ligase AAE7, peroxisomal [KO:K01913] [EC:6.2.1.1 6.2.1.2]
            25495288  galactose mutarotase isoform X1 [KO:K01785] [EC:5.1.3.3]
            25495289  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
            11440207  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
            11413122  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
            11427981  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
            11413693  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
            11414670  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
            11431767  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11439651  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11419460  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            25495118  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11426124  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11438410  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11406522  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
            11415895  multiple inositol polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
            11436321  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
            11423304  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
            25501396  phosphoenolpyruvate carboxykinase (ATP) 1 [KO:K01610] [EC:4.1.1.49]
            11433679  phosphoenolpyruvate carboxykinase (ATP) 1 [KO:K01610] [EC:4.1.1.49]
            25495006  phosphoenolpyruvate carboxykinase (ATP) 1 [KO:K01610] [EC:4.1.1.49]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00031  D-Glucose
            C00033  Acetate
            C00036  Oxaloacetate
            C00068  Thiamin diphosphate
            C00074  Phosphoenolpyruvate
            C00084  Acetaldehyde
            C00103  D-Glucose 1-phosphate
            C00111  Glycerone phosphate
            C00118  D-Glyceraldehyde 3-phosphate
            C00186  (S)-Lactate
            C00197  3-Phospho-D-glycerate
            C00221  beta-D-Glucose
            C00236  3-Phospho-D-glyceroyl phosphate
            C00267  alpha-D-Glucose
            C00469  Ethanol
            C00631  2-Phospho-D-glycerate
            C00668  alpha-D-Glucose 6-phosphate
            C01159  2,3-Bisphospho-D-glycerate
            C01172  beta-D-Glucose 6-phosphate
            C01451  Salicin
            C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
            C05345  beta-D-Fructose 6-phosphate
            C05378  beta-D-Fructose 1,6-bisphosphate
            C06186  Arbutin
            C06187  Arbutin 6-phosphate
            C06188  Salicin 6-phosphate
            C15972  Enzyme N6-(lipoyl)lysine
            C15973  Enzyme N6-(dihydrolipoyl)lysine
            C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
REFERENCE   
  AUTHORS   Nishizuka Y (ed).
  TITLE     [Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1980)
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   
  AUTHORS   Michal G.
  TITLE     Biochemical Pathways
  JOURNAL   Wiley (1999)
REL_PATHWAY mtr00020  Citrate cycle (TCA cycle)
            mtr00030  Pentose phosphate pathway
            mtr00500  Starch and sucrose metabolism
            mtr00620  Pyruvate metabolism
            mtr00640  Propanoate metabolism
            mtr00710  Carbon fixation in photosynthetic organisms
KO_PATHWAY  ko00010
///
