ENTRY       hsa03250                    Pathway
NAME        Viral life cycle - HIV-1 - Homo sapiens (human)
CLASS       Genetic Information Processing; Information processing in viruses
PATHWAY_MAP hsa03250  Viral life cycle - HIV-1
DRUG        D03210  Ancriviroc (USAN/INN)
            D06297  Vicriviroc maleate (USAN)
            D06557  Aplaviroc hydrochloride (USAN)
            D06670  Maraviroc (JAN/INN)
            D09575  Ibalizumab (USAN/INN)
            D09878  Cenicriviroc (USAN/INN)
            D10087  Alisporivir (USAN)
            D11399  Leronlimab (USAN/INN)
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        1234  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
            7852  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
            920  CD4; CD4 molecule [KO:K06454]
            4130  MAP1A; microtubule associated protein 1A [KO:K10429]
            4131  MAP1B; microtubule associated protein 1B [KO:K10429]
            55201  MAP1S; microtubule associated protein 1S [KO:K10429]
            9638  FEZ1; fasciculation and elongation protein zeta 1 [KO:K25663]
            23299  BICD2; BICD cargo adaptor 2 [KO:K18739]
            636  BICD1; BICD cargo adaptor 1 [KO:K18739]
            85363  TRIM5; tripartite motif containing 5 [KO:K10648] [EC:2.3.2.27]
            164668  APOBEC3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H [KO:K18750] [EC:3.5.4.-]
            200316  APOBEC3F; apolipoprotein B mRNA editing enzyme catalytic subunit 3F [KO:K18750] [EC:3.5.4.-]
            100913187  APOBEC3A_B; APOBEC3A and APOBEC3B deletion hybrid [KO:K18750] [EC:3.5.4.-]
            140564  APOBEC3D; apolipoprotein B mRNA editing enzyme catalytic subunit 3D [KO:K18750] [EC:3.5.4.-]
            200315  APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A [KO:K18750] [EC:3.5.4.-]
            27350  APOBEC3C; apolipoprotein B mRNA editing enzyme catalytic subunit 3C [KO:K18750] [EC:3.5.4.-]
            60489  APOBEC3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G [KO:K18750] [EC:3.5.4.-]
            9582  APOBEC3B; apolipoprotein B mRNA editing enzyme catalytic subunit 3B [KO:K18750] [EC:3.5.4.-]
            25939  SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [KO:K22544] [EC:3.1.5.-]
            11168  PSIP1; PC4 and SRSF1 interacting protein 1 [KO:K25057]
            5300  PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
            6598  SMARCB1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [KO:K11648]
            5478  PPIA; peptidylprolyl isomerase A [KO:K03767] [EC:5.2.1.8]
            11052  CPSF6; cleavage and polyadenylation specific factor 6 [KO:K14398]
            79869  CPSF7; cleavage and polyadenylation specific factor 7 [KO:K14398]
            23534  TNPO3; transportin 3 [KO:K15436]
            4599  MX1; MX dynamin like GTPase 1 [KO:K14754]
            4600  MX2; MX dynamin like GTPase 2 [KO:K14754]
            5903  RANBP2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
            9972  NUP153; nucleoporin 153 [KO:K14296]
            1387  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
            2033  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
            8850  KAT2B; lysine acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
            2648  KAT2A; lysine acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
            1025  CDK9; cyclin dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
            904  CCNT1; cyclin T1 [KO:K15188]
            905  CCNT2; cyclin T2 [KO:K15188]
            27125  AFF4; ALF transcription elongation factor 4 [KO:K15185]
            22936  ELL2; elongation factor for RNA polymerase II 2 [KO:K15183]
            80237  ELL3; elongation factor for RNA polymerase II 3 [KO:K15183]
            8178  ELL; elongation factor for RNA polymerase II [KO:K15183]
            4298  MLLT1; MLLT1 super elongation complex subunit [KO:K15187]
            4300  MLLT3; MLLT3 super elongation complex subunit [KO:K15187]
            7469  NELFA; negative elongation factor complex member A [KO:K15179]
            25920  NELFB; negative elongation factor complex member B [KO:K15180]
            51497  NELFCD; negative elongation factor complex member C/D [KO:K15181]
            7936  NELFE; negative elongation factor complex member E [KO:K15182]
            6827  SUPT4H1; SPT4 homolog, DSIF elongation factor subunit [KO:K15171]
            6829  SUPT5H; SPT5 homolog, DSIF elongation factor subunit [KO:K15172]
            7514  XPO1; exportin 1 [KO:K14290]
            5901  RAN; RAN, member RAS oncogene family [KO:K07936]
            5045  FURIN; furin, paired basic amino acid cleaving enzyme [KO:K01349] [EC:3.4.21.75]
            10955  SERINC3; serine incorporator 3 [KO:K25661]
            256987  SERINC5; serine incorporator 5 [KO:K25655]
            684  BST2; bone marrow stromal cell antigen 2 [KO:K06731]
            9146  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
            7251  TSG101; tumor susceptibility 101 [KO:K12183]
            79643  CHMP6; charged multivesicular body protein 6 [KO:K12195]
            128866  CHMP4B; charged multivesicular body protein 4B [KO:K12194]
            29082  CHMP4A; charged multivesicular body protein 4A [KO:K12194]
            10015  PDCD6IP; programmed cell death 6 interacting protein [KO:K12200]
            9525  VPS4B; vacuolar protein sorting 4 homolog B [KO:K12196]
            27183  VPS4A; vacuolar protein sorting 4 homolog A [KO:K12196]
REFERENCE   PMID:27357278
  AUTHORS   Li G, De Clercq E
  TITLE     HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.
  JOURNAL   Microbiol Mol Biol Rev 80:679-731 (2016)
            DOI:10.1128/MMBR.00065-15
REFERENCE   PMID:21284899
  AUTHORS   Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L
  TITLE     Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.
  JOURNAL   J Transl Med 9 Suppl 1:S1 (2011)
            DOI:10.1186/1479-5876-9-S1-S1
REFERENCE   PMID:31028522
  AUTHORS   Novikova M, Zhang Y, Freed EO, Peng K
  TITLE     Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.
  JOURNAL   Virol Sin 34:119-134 (2019)
            DOI:10.1007/s12250-019-00095-3
REFERENCE   PMID:30286189
  AUTHORS   Rawle DJ, Harrich D
  TITLE     Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating.
  JOURNAL   PLoS Pathog 14:e1007270 (2018)
            DOI:10.1371/journal.ppat.1007270
REFERENCE   PMID:25036886
  AUTHORS   Le Sage V, Mouland AJ, Valiente-Echeverria F
  TITLE     Roles of HIV-1 capsid in viral replication and immune evasion.
  JOURNAL   Virus Res 193:116-29 (2014)
            DOI:10.1016/j.virusres.2014.07.010
REFERENCE   PMID:32429351
  AUTHORS   Murphy RE, Saad JS
  TITLE     The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation.
  JOURNAL   Viruses 12:E548 (2020)
            DOI:10.3390/v12050548
REFERENCE   PMID:21360054
  AUTHORS   He N, Zhou Q
  TITLE     New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
  JOURNAL   J Neuroimmune Pharmacol 6:260-8 (2011)
            DOI:10.1007/s11481-011-9267-6
REFERENCE   PMID:19865606
  AUTHORS   Pincetic A, Leis J
  TITLE     The Mechanism of Budding of Retroviruses From Cell Membranes.
  JOURNAL   Adv Virol 2009:6239691-6239699 (2009)
            DOI:10.1155/2009/623969
REFERENCE   PMID:32858867
  AUTHORS   Kleinpeter AB, Freed EO
  TITLE     HIV-1 Maturation: Lessons Learned from Inhibitors.
  JOURNAL   Viruses 12:E940 (2020)
            DOI:10.3390/v12090940
REL_PATHWAY hsa03013  Nucleocytoplasmic transport
            hsa04144  Endocytosis
KO_PATHWAY  ko03250
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