ENTRY       hsa00982                    Pathway
NAME        Drug metabolism - cytochrome P450 - Homo sapiens (human)
CLASS       Metabolism; Xenobiotics biodegradation and metabolism
PATHWAY_MAP hsa00982  Drug metabolism - cytochrome P450
DRUG        D00505  Phenelzine sulfate (USP)
            D00826  Tranylcypromine sulfate (USP)
            D01888  Safrazine hydrochloride (JAN)
            D02559  Toloxatone (INN)
            D02560  Brofaromine (INN)
            D02561  Moclobemide (USAN/INN)
            D02563  Befloxatone (INN)
            D02579  Iproniazid (INN)
            D02580  Isocarboxazid (INN)
            D03248  Clorgiline (INN)
            D03409  Caroxazone (USAN/INN)
            D04092  Etryptamine acetate (USAN)
            D07337  Nialamide (INN)
            D07338  Iproclozide (INN)
            D08085  Iproniazid phosphate
            D08349  Phenelzine (BAN)
            D08392  Pirlindole (INN)
            D08393  Pirlindole hydrochloride
            D08625  Tranylcypromine (INN)
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        1565  CYP2D6; cytochrome P450 family 2 subfamily D member 6 [KO:K17712] [EC:1.14.14.1]
            107987478  cytochrome P450 2D6-like [KO:K17712] [EC:1.14.14.1]
            1564  CYP2D7; cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) [KO:K17712] [EC:1.14.14.1]
            107987479  CYP2D6; cytochrome P450 2D6 [KO:K17712] [EC:1.14.14.1]
            1559  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
            1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
            2326  FMO1; flavin containing dimethylaniline monoxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
            2327  FMO2; flavin containing dimethylaniline monoxygenase 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
            2330  FMO5; flavin containing dimethylaniline monoxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
            2328  FMO3; flavin containing dimethylaniline monoxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
            2329  FMO4; flavin containing dimethylaniline monoxygenase 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
            1557  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17721] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
            1555  CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.14.-]
            1577  CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
            221357  GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
            2939  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
            2941  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
            119391  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
            2948  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
            2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
            2952  GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
            2947  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
            4257  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
            4259  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            2944  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
            2949  GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
            4258  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
            2938  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
            2946  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
            2940  GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
            9446  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
            653689  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
            2950  GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18]
            373156  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
            27306  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
            124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
            125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
            126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
            131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
            127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
            128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
            221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
            222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
            218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
            4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
            4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
            316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
            10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
            79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
            7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
            10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
            54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
            54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
            54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
            54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
            54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
            7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
            54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
            7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
            54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
            54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
            54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
            7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
            54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
            7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
            574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
            1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
            1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
            1558  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
            1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-]
            1549  CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-]
COMPOUND    C01471  Acrolein
            C01516  Morphine
            C05011  Hydroxytamoxifen
            C06174  Codeine
            C06754  Chloroacetaldehyde
            C06868  Carbamazepine
            C07047  Ifosfamide
            C07073  Lidocaine
            C07108  Tamoxifen
            C07163  Methadone
            C07185  Valproic acid
            C07492  Oxcarbazepine
            C07493  10-Hydroxycarbazepine
            C07495  Dihydroxycarbazepine
            C07496  Carbamazepine-10,11-epoxide
            C07501  Felbamate
            C07572  Citalopram
            C07643  4-Hydroxycyclophosphamide
            C07644  4-Ketocyclophosphamide
            C07645  Aldophosphamide
            C07646  Carboxyphosphamide
            C07647  Phosphoramide mustard
            C07888  Cyclophosphamide
            C08012  Levomethadyl acetate
            C11004  2,6-Dimethylaniline
            C11583  4-Glutathionyl cyclophosphamide
            C11785  Normorphine
            C16544  alpha-Hydroxytamoxifen
            C16545  Tamoxifen N-oxide
            C16546  N-Desmethyltamoxifen
            C16547  Endoxifen
            C16548  N,N-Didesmethyltamoxifen
            C16549  alpha-Hydroxy-N-desmethyltamoxifen
            C16550  Dechloroethylcyclophosphamide
            C16551  Alcophosphamide
            C16552  Nornitrogen mustard
            C16553  4-Hydroxyifosfamide
            C16554  4-Ketoifosfamide
            C16555  2-Dechloroethylifosfamide
            C16556  Aldoifosfamide
            C16557  Carboxyifosfamide
            C16558  Alcoifosfamide
            C16559  Isophosphoramide mustard
            C16560  3-Hydroxylidocaine
            C16561  Monoethylglycinexylidide
            C16569  Glycinexylidide
            C16570  4-Hydroxy-2,6-dimethylaniline
            C16571  2-Amino-3-methylbenzoate
            C16572  3-Hydroxymonoethylglycinexylidide
            C16576  Norcodeine
            C16577  Codeine-6-glucuronide
            C16578  Morphine-6-glucuronide
            C16582  2-Hydroxyfelbamate
            C16584  p-Hydroxyfelbamate
            C16586  2-Phenyl-1,3-propanediol monocarbamate
            C16587  3-Carbamoyl-2-phenylpropionaldehyde
            C16591  3-Carbamoyl-2-phenylpropionic acid
            C16592  Atropaldehyde
            C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
            C16596  5-Phenyl-1,3-oxazinane-2,4-dione
            C16601  2-Hydroxycarbamazepine
            C16602  3-Hydroxycarbamazepine
            C16603  2,3-Dihydroxycarbamazepine
            C16604  2-Hydroxyiminostilbene
            C16605  2H-Dibenz[b,f]azepin-2-one
            C16606  Carbamazepine-o-quinone
            C16607  Citalopram N-oxide
            C16608  Demethylcitalopram
            C16609  Didemethylcitalopram
            C16610  Citalopram propionic acid
            C16612  Citalopram aldehyde
            C16643  Morphine-3-glucuronide
            C16648  2-n-Propyl-4-pentenoic acid
            C16649  4-Hydroxyvalproic acid
            C16650  5-Hydroxyvalproic acid
            C16651  3-Hydroxyvalproic acid
            C16652  3-Oxovalproic acid
            C16653  2-n-Propyl-2-pentenoic acid
            C16654  2-n-Propyl-3-pentenoic acid
            C16655  2-n-Propyl-4-oxopentanoic acid
            C16656  2-Propyl-2,4-pentadienoic acid
            C16657  2-Propylsuccinic acid
            C16658  2-Propylglutaric acid
            C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
            C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
            C16661  L-alpha-Acetyl-N-normethadol
            C16662  L-alpha-Acetyl-N,N-dinormethadol
            D00195  Codeine (USP)
            D00252  Carbamazepine (JP18/USP/INN)
            D00343  Ifosfamide (JAN/USP/INN)
            D00358  Lidocaine (JP18/USP/INN)
            D00399  Valproic acid (USP)
            D00533  Oxcarbazepine (JAN/USP/INN)
            D00536  Felbamate (USPINN)
            D04716  Levomethadyl acetate (USAN)
            D07704  Citalopram (USP/INN)
            D07760  Cyclophosphamide (INN)
            D08195  Methadone (BAN)
            D08233  Morphine (BAN)
            D08559  Tamoxifen (INN)
REFERENCE   
  AUTHORS   Kato R, Kamatari T (eds).
  TITLE     [Drug Metabolism] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (2000)
REFERENCE   PMID:16038189
  AUTHORS   Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  TITLE     Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  JOURNAL   J Chromatogr A 1082:6-14 (2005)
            DOI:10.1016/j.chroma.2005.01.004
REFERENCE   PMID:18043895
  AUTHORS   Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  TITLE     TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  JOURNAL   Breast Cancer Res Treat 107:15-24 (2008)
            DOI:10.1007/s10549-007-9526-7
REFERENCE   PMID:16550168
  AUTHORS   Rodriguez-Antona C, Ingelman-Sundberg M.
  TITLE     Cytochrome P450 pharmacogenetics and cancer.
  JOURNAL   Oncogene 25:1679-91 (2006)
            DOI:10.1038/sj.onc.1209377
REFERENCE   PMID:16393888
  AUTHORS   Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  TITLE     Metabolism and transport of oxazaphosphorines and the clinical implications.
  JOURNAL   Drug Metab Rev 37:611-703 (2005)
            DOI:10.1080/03602530500364023
REFERENCE   PMID:11226815
  AUTHORS   Kosel M, Amey M, Aubert AC, Baumann P.
  TITLE     In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  JOURNAL   Eur Neuropsychopharmacol 11:75-8 (2001)
            DOI:10.1016/S0924-977X(00)00128-0
REFERENCE   PMID:10575324
  AUTHORS   Olesen OV, Linnet K.
  TITLE     Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  JOURNAL   Pharmacology 59:298-309 (1999)
            DOI:10.1159/000028333
REFERENCE   PMID:9698084
  AUTHORS   Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  TITLE     Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  JOURNAL   Biochem Pharmacol 56:15-23 (1998)
            DOI:10.1016/S0006-2952(98)00008-2
REFERENCE   
  AUTHORS   David AW, Thomas LL, William OF.
  TITLE     Foye's Principles of Medicinal Chemistry (5th ed)
  JOURNAL   Lippincott Williams & Wilkins (2002)
REFERENCE   PMID:11504799
  AUTHORS   Oda Y, Kharasch ED.
  TITLE     Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  JOURNAL   J Pharmacol Exp Ther 298:1021-32 (2001)
REFERENCE   PMID:10901707
  AUTHORS   Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  TITLE     Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  JOURNAL   Drug Metab Dispos 28:959-65 (2000)
REFERENCE   PMID:12399158
  AUTHORS   Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  TITLE     Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  JOURNAL   Chem Biol Interact 142:99-117 (2002)
            DOI:10.1016/S0009-2797(02)00057-1
REFERENCE   PMID:18463198
  AUTHORS   Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  TITLE     Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  JOURNAL   Drug Metab Dispos 36:1637-49 (2008)
            DOI:10.1124/dmd.107.019562
REFERENCE   PMID:12386121
  AUTHORS   Pearce RE, Vakkalagadda GR, Leeder JS.
  TITLE     Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  JOURNAL   Drug Metab Dispos 30:1170-9 (2002)
            DOI:10.1124/dmd.30.11.1170
REFERENCE   PMID:10859160
  AUTHORS   Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  TITLE     Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  JOURNAL   Drug Metab Dispos 28:857-64 (2000)
REFERENCE   
  AUTHORS   Bernad T, Joachim M.
  TITLE     Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  JOURNAL   Wiley-VCH (2003)
KO_PATHWAY  ko00982
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