ENTRY       hsa00980                    Pathway
NAME        Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
CLASS       Metabolism; Xenobiotics biodegradation and metabolism
PATHWAY_MAP hsa00980  Metabolism of xenobiotics by cytochrome P450
DRUG        D00707  Fomepizole (JAN/USAN/INN)
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
            1559  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
            1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
            1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
            221357  GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
            2939  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
            2941  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
            119391  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
            2948  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
            2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
            2952  GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
            2947  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
            4257  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
            4259  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            2944  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
            2949  GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
            4258  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
            2938  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
            2946  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
            2940  GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
            9446  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
            653689  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
            2950  GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18]
            373156  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
            27306  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
            2052  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
            1555  CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.14.-]
            6822  SULT2A1; sulfotransferase family 2A member 1 [KO:K11822] [EC:2.8.2.14]
            1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
            1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-]
            1549  CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-]
            1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
            1572  CYP2F1; cytochrome P450 family 2 subfamily F member 1 [KO:K07416] [EC:1.14.14.1]
            29785  CYP2S1; cytochrome P450 family 2 subfamily S member 1 [KO:K07420] [EC:1.14.14.1]
            1645  AKR1C1; aldo-keto reductase family 1 member C1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
            27294  DHDH; dihydrodiol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
            1553  CYP2A13; cytochrome P450 family 2 subfamily A member 13 [KO:K17685] [EC:1.14.14.1]
            1565  CYP2D6; cytochrome P450 family 2 subfamily D member 6 [KO:K17712] [EC:1.14.14.1]
            107987478  cytochrome P450 2D6-like [KO:K17712] [EC:1.14.14.1]
            1564  CYP2D7; cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) [KO:K17712] [EC:1.14.14.1]
            107987479  CYP2D6; cytochrome P450 2D6 [KO:K17712] [EC:1.14.14.1]
            3290  HSD11B1; hydroxysteroid 11-beta dehydrogenase 1 [KO:K15680] [EC:1.1.1.146]
            374875  HSD11B1L; hydroxysteroid 11-beta dehydrogenase 1 like [KO:K15680] [EC:1.1.1.146]
            873  CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            874  CBR3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
            10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
            79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
            7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
            10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
            54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
            54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
            54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
            54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
            54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
            7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
            54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
            7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
            54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
            54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
            54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
            7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
            54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
            7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
            574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
            1577  CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
            8574  AKR7A2; aldo-keto reductase family 7 member A2 [KO:K15303]
            22977  AKR7A3; aldo-keto reductase family 7 member A3 [KO:K15303]
            246181  AKR7L; aldo-keto reductase family 7 like (gene/pseudogene) [KO:K15303]
            221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
            222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
            218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
            124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
            125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
            126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
            131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
            127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
            128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
COMPOUND    C00745  Nicotine
            C00829  Naphthalene
            C02617  1,4-Naphthoquinone
            C03012  Naphthalene-1,2-diol
            C06205  1,2-Dihydronaphthalene-1,2-diol
            C06755  Chloroacetic acid
            C06790  Trichloroethene
            C06800  Aflatoxin B1
            C06899  Chloral hydrate
            C07490  Trichloroethanol
            C07535  Benzo[a]pyrene
            C11036  Bromobenzene
            C11088  1,2-Dibromoethane
            C11148  TCE epoxide
            C11149  Dichloroacetate
            C11150  Trichloroacetate
            C11278  Aflatoxin B1exo-8,9-epoxide-GSH
            C11713  2-Naphthol
            C11714  1-Naphthol
            C14039  1,1-Dichloroethylene
            C14040  1-Nitronaphthalene
            C14453  4-Bromophenol
            C14556  9-Hydroxybenzo[a]pyrene
            C14783  1,2-Naphthoquinone
            C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
            C14785  1,4-Dihydroxynaphthalene
            C14786  (1R,2S)-Naphthalene 1,2-oxide
            C14787  (1S,2R)-Naphthalene 1,2-oxide
            C14788  1-Nitrosonaphthalene
            C14789  N-Hydroxy-1-aminonaphthalene
            C14790  1-Naphthylamine
            C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
            C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
            C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
            C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
            C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
            C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
            C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
            C14800  1-Nitronaphthalene-5,6-oxide
            C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
            C14802  1-Nitronaphthalene-7,8-oxide
            C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
            C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
            C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
            C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
            C14839  Bromobenzene-3,4-oxide
            C14840  Bromobenzene-2,3-oxide
            C14841  2-Bromophenol
            C14842  Bromobenzene-2,3-dihydrodiol
            C14843  4-Bromocatechol
            C14844  Bromobenzene-3,4-dihydrodiol
            C14845  4-Bromophenol-2,3-epoxide
            C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
            C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
            C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
            C14849  Benzo[a]pyrene-9,10-oxide
            C14850  Benzo[a]pyrene-7,8-oxide
            C14851  Benzo[a]pyrene-4,5-oxide
            C14852  Benzo[a]pyrene-7,8-dihydrodiol
            C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
            C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
            C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
            C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
            C14857  1,1-Dichloroethylene epoxide
            C14858  2,2-Dichloroacetaldehyde
            C14859  Chloroacetyl chloride
            C14860  2,2-Dichloro-1,1-ethanediol
            C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
            C14862  2-S-Glutathionyl acetate
            C14863  2-(S-Glutathionyl)acetyl glutathione
            C14864  S-(2-Chloroacetyl)glutathione
            C14865  2-(S-Glutathionyl)acetyl chloride
            C14866  Chloral
            C14867  Dichloroacetyl chloride
            C14868  S-(1,2-Dichlorovinyl)glutathione
            C14869  Trichloroethanol glucuronide
            C14870  2-Bromoacetaldehyde
            C14871  S-(Formylmethyl)glutathione
            C14872  Thiodiacetic acid
            C14873  Thiodiacetic acid sulfoxide
            C14874  Glutathione episulfonium ion
            C14875  S-(2-Hydroxyethyl)glutathione
            C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
            C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
            C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
            C16756  Aflatoxin M1
            C19488  7,12-Dimethylbenz[a]anthracene
            C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
            C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
            C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
            C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
            C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
            C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
            C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
            C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
            C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
            C19567  4-Oxo-1-(3-pyridyl)-1-butanone
            C19568  N-Nitrosomethanamine
            C19569  3-Succinoylpyridine
            C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
            C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
            C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
            C19579  gamma-Hydroxy-3-pyridinebutanoate
            C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
            C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
            C19582  1-(3-Pyridinyl)-1,4-butanediol
            C19585  Aflatoxin Q1
            C19586  Aflatoxin B1-exo-8,9-epoxide
            C19588  Aflatoxin B1 diol
            C19589  Aflatoxin B1 dialdehyde
            C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
            C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
            C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
            C19594  Aflatoxin-M1-8,9-epoxide
            C19595  Aflatoxin B1-endo-8,9-epoxide
            C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
            C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
            C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
            C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
            C19606  NNAL-N-glucuronide
            C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
REFERENCE   PMID:12487150
  AUTHORS   Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  TITLE     Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  JOURNAL   Drug Metab Rev 34:791-820 (2002)
            DOI:10.1081/DMR-120015694
REFERENCE   PMID:10725110
  AUTHORS   Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  TITLE     Role of quinones in toxicology.
  JOURNAL   Chem Res Toxicol 13:135-60 (2000)
            DOI:10.1021/tx9902082
REFERENCE   PMID:10570027
  AUTHORS   Halladay JS, Sauer JM, Sipes IG.
  TITLE     Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  JOURNAL   Drug Metab Dispos 27:1456-65 (1999)
REFERENCE   PMID:10490505
  AUTHORS   Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  TITLE     Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  JOURNAL   Chem Res Toxicol 12:831-9 (1999)
            DOI:10.1021/tx990023v
REFERENCE   PMID:15319346
  AUTHORS   Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  TITLE     Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  JOURNAL   Drug Metab Dispos 32:1032-9 (2004)
REFERENCE   PMID:15987776
  AUTHORS   Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  TITLE     Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  JOURNAL   Drug Metab Dispos 33:1429-37 (2005)
            DOI:10.1124/dmd.105.005074
REFERENCE   PMID:9107551
  AUTHORS   Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  TITLE     Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  JOURNAL   Drug Metab Dispos 25:508-15 (1997)
REFERENCE   PMID:4395686
  AUTHORS   Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  TITLE     Possible mechanism of liver necrosis caused by aromatic organic compounds.
  JOURNAL   Proc Natl Acad Sci U S A 68:160-4 (1971)
            DOI:10.1073/pnas.68.1.160
REFERENCE   PMID:15298956
  AUTHORS   Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  TITLE     Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
REFERENCE   
  AUTHORS   Omura T, Ishimura Y, Fujii Y (eds).
  TITLE     [Molecular Biology of P450] (In Japanese)
  JOURNAL   Kodansya (2003)
KO_PATHWAY  ko00980
///
