ENTRY       hsa00970                    Pathway
NAME        Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP hsa00970  Aminoacyl-tRNA biosynthesis
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        4553  TRNA; tRNA-Ala [KO:K14218]
            4573  TRNR; tRNA-Arg [KO:K14219]
            4570  TRNN; tRNA-Asn [KO:K14220]
            4555  TRND; tRNA-Asp [KO:K14221]
            4511  TRNC; tRNA-Cys [KO:K14222]
            4572  TRNQ; tRNA-Gln [KO:K14223]
            4556  TRNE; tRNA-Glu [KO:K14224]
            4563  TRNG; tRNA-Gly [KO:K14225]
            4564  TRNH; tRNA-His [KO:K14226]
            4565  TRNI; tRNA-Ile [KO:K14227]
            4568  TRNL2; tRNA-Leu [KO:K14228]
            4567  TRNL1; tRNA-Leu [KO:K14228]
            4566  TRNK; tRNA-Lys [KO:K14229]
            4569  TRNM; tRNA-Met [KO:K14230]
            4558  TRNF; tRNA-Phe [KO:K14231]
            4571  TRNP; tRNA-Pro [KO:K14232]
            4575  TRNS2; tRNA-Ser [KO:K14233]
            4574  TRNS1; tRNA-Ser [KO:K14233]
            4576  TRNT; tRNA-Thr [KO:K14234]
            4578  TRNW; tRNA-Trp [KO:K14235]
            4579  TRNY; tRNA-Tyr [KO:K14236]
            4577  TRNV; tRNA-Val [KO:K14237]
            124454  EARS2; glutamyl-tRNA synthetase 2, mitochondrial [KO:K01885] [EC:6.1.1.17]
            2058  EPRS1; glutamyl-prolyl-tRNA synthetase 1 [KO:K14163] [EC:6.1.1.17 6.1.1.15]
            55278  QRSL1; glutaminyl-tRNA amidotransferase subunit QRSL1 [KO:K02433] [EC:6.3.5.6 6.3.5.7]
            5188  GATB; glutamyl-tRNA amidotransferase subunit B [KO:K02434] [EC:6.3.5.6 6.3.5.7]
            283459  GATC; glutamyl-tRNA amidotransferase subunit C [KO:K02435] [EC:6.3.5.6 6.3.5.7]
            5859  QARS1; glutaminyl-tRNA synthetase 1 [KO:K01886] [EC:6.1.1.18]
            57505  AARS2; alanyl-tRNA synthetase 2, mitochondrial [KO:K01872] [EC:6.1.1.7]
            16  AARS1; alanyl-tRNA synthetase 1 [KO:K01872] [EC:6.1.1.7]
            1615  DARS1; aspartyl-tRNA synthetase 1 [KO:K22503] [EC:6.1.1.12]
            55157  DARS2; aspartyl-tRNA synthetase 2, mitochondrial [KO:K01876] [EC:6.1.1.12]
            79731  NARS2; asparaginyl-tRNA synthetase 2, mitochondrial [KO:K01893] [EC:6.1.1.22]
            4677  NARS1; asparaginyl-tRNA synthetase 1 [KO:K01893] [EC:6.1.1.22]
            2617  GARS1; glycyl-tRNA synthetase 1 [KO:K01880] [EC:6.1.1.14]
            80222  TARS2; threonyl-tRNA synthetase 2, mitochondrial [KO:K01868] [EC:6.1.1.3]
            6897  TARS1; threonyl-tRNA synthetase 1 [KO:K01868] [EC:6.1.1.3]
            123283  TARS3; threonyl-tRNA synthetase 3 [KO:K01868] [EC:6.1.1.3]
            54938  SARS2; seryl-tRNA synthetase 2, mitochondrial [KO:K01875] [EC:6.1.1.11]
            6301  SARS1; seryl-tRNA synthetase 1 [KO:K01875] [EC:6.1.1.11]
            118672  PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
            51091  SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
            833  CARS1; cysteinyl-tRNA synthetase 1 [KO:K01883] [EC:6.1.1.16]
            79587  CARS2; cysteinyl-tRNA synthetase 2, mitochondrial [KO:K01883] [EC:6.1.1.16]
            4141  MARS1; methionyl-tRNA synthetase 1 [KO:K01874] [EC:6.1.1.10]
            92935  MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
            123263  MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
            57176  VARS2; valyl-tRNA synthetase 2, mitochondrial [KO:K01873] [EC:6.1.1.9]
            7407  VARS1; valyl-tRNA synthetase 1 [KO:K01873] [EC:6.1.1.9]
            51520  LARS1; leucyl-tRNA synthetase 1 [KO:K01869] [EC:6.1.1.4]
            23395  LARS2; leucyl-tRNA synthetase 2, mitochondrial [KO:K01869] [EC:6.1.1.4]
            3376  IARS1; isoleucyl-tRNA synthetase 1 [KO:K01870] [EC:6.1.1.5]
            55699  IARS2; isoleucyl-tRNA synthetase 2, mitochondrial [KO:K01870] [EC:6.1.1.5]
            3735  KARS1; lysyl-tRNA synthetase 1 [KO:K04567] [EC:6.1.1.6]
            57038  RARS2; arginyl-tRNA synthetase 2, mitochondrial [KO:K01887] [EC:6.1.1.19]
            5917  RARS1; arginyl-tRNA synthetase 1 [KO:K01887] [EC:6.1.1.19]
            25973  PARS2; prolyl-tRNA synthetase 2, mitochondrial [KO:K01881] [EC:6.1.1.15]
            3035  HARS1; histidyl-tRNA synthetase 1 [KO:K01892] [EC:6.1.1.21]
            23438  HARS2; histidyl-tRNA synthetase 2, mitochondrial [KO:K01892] [EC:6.1.1.21]
            2193  FARSA; phenylalanyl-tRNA synthetase subunit alpha [KO:K01889] [EC:6.1.1.20]
            10667  FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial [KO:K01889] [EC:6.1.1.20]
            10056  FARSB; phenylalanyl-tRNA synthetase subunit beta [KO:K01890] [EC:6.1.1.20]
            8565  YARS1; tyrosyl-tRNA synthetase 1 [KO:K01866] [EC:6.1.1.1]
            51067  YARS2; tyrosyl-tRNA synthetase 2 [KO:K01866] [EC:6.1.1.1]
            10352  WARS2; tryptophanyl tRNA synthetase 2, mitochondrial [KO:K01867] [EC:6.1.1.2]
            7453  WARS1; tryptophanyl-tRNA synthetase 1 [KO:K01867] [EC:6.1.1.2]
COMPOUND    C00025  L-Glutamate
            C00037  Glycine
            C00041  L-Alanine
            C00047  L-Lysine
            C00049  L-Aspartate
            C00062  L-Arginine
            C00064  L-Glutamine
            C00065  L-Serine
            C00073  L-Methionine
            C00078  L-Tryptophan
            C00079  L-Phenylalanine
            C00082  L-Tyrosine
            C00097  L-Cysteine
            C00101  Tetrahydrofolate
            C00123  L-Leucine
            C00135  L-Histidine
            C00148  L-Proline
            C00152  L-Asparagine
            C00183  L-Valine
            C00188  L-Threonine
            C00234  10-Formyltetrahydrofolate
            C00407  L-Isoleucine
            C00886  L-Alanyl-tRNA
            C01005  O-Phospho-L-serine
            C01931  L-Lysyl-tRNA
            C02047  L-Leucyl-tRNA
            C02163  L-Arginyl-tRNA(Arg)
            C02282  Glutaminyl-tRNA
            C02412  Glycyl-tRNA(Gly)
            C02430  L-Methionyl-tRNA
            C02553  L-Seryl-tRNA(Ser)
            C02554  L-Valyl-tRNA(Val)
            C02702  L-Prolyl-tRNA(Pro)
            C02839  L-Tyrosyl-tRNA(Tyr)
            C02984  L-Aspartyl-tRNA(Asp)
            C02987  L-Glutamyl-tRNA(Glu)
            C02988  L-Histidyl-tRNA(His)
            C02992  L-Threonyl-tRNA(Thr)
            C03125  L-Cysteinyl-tRNA(Cys)
            C03127  L-Isoleucyl-tRNA(Ile)
            C03294  N-Formylmethionyl-tRNA
            C03402  L-Asparaginyl-tRNA(Asn)
            C03511  L-Phenylalanyl-tRNA(Phe)
            C03512  L-Tryptophanyl-tRNA(Trp)
            C06112  L-Glutamyl-tRNA(Gln)
            C06113  L-Aspartyl-tRNA(Asn)
            C06481  L-Seryl-tRNA(Sec)
            C06482  L-Selenocysteinyl-tRNA(Sec)
            C16138  L-Pyrrolysine
            C16638  O-Phosphoseryl-tRNA(Sec)
            C17022  O-Phosphoseryl-tRNA(Cys)
            C17027  L-Pyrrolysyl-tRNA(Pyl)
REFERENCE   PMID:18252769
  AUTHORS   Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  TITLE     From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  JOURNAL   Nucleic Acids Res 36:1813-25 (2008)
            DOI:10.1093/nar/gkn015
REFERENCE   PMID:15314242
  AUTHORS   Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  TITLE     An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  JOURNAL   Proc Natl Acad Sci U S A 101:12450-4 (2004)
            DOI:10.1073/pnas.0405362101
REL_PATHWAY hsa00250  Alanine, aspartate and glutamate metabolism
            hsa00260  Glycine, serine and threonine metabolism
            hsa00270  Cysteine and methionine metabolism
            hsa00290  Valine, leucine and isoleucine biosynthesis
            hsa00330  Arginine and proline metabolism
            hsa00340  Histidine metabolism
            hsa00380  Tryptophan metabolism
            hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO_PATHWAY  ko00970
///
