ENTRY       hsa00790                    Pathway
NAME        Folate biosynthesis - Homo sapiens (human)
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP hsa00790  Folate biosynthesis
MODULE      hsa_M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:hsa00790]
            hsa_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:hsa00790]
NETWORK     nt06016  Phenylalanine and tyrosine metabolism
            nt06025  Molybdenum cofactor biosynthesis
            nt06028  Dopamine and serotonin metabolism
  ELEMENT   N00700  Tyrosine biosynthesis
            N00702  Tetrahydrobiopterin biosynthesis, GTP to BH4
            N00705  Tetrahydrobiopterin biosynthesis, BH4OH to BH4
            N00890  Molybdenum cofactor biosynthesis
DRUG        D00142  Methotrexate (JP18/USP/INN)
            D02115  Methotrexate sodium
            D03828  Pemetrexed disodium (USAN)
            D03942  Edatrexate (USAN/INN)
            D05500  Piritrexim isethionate (USAN)
            D05589  Pralatrexate (JAN/USAN/INN)
            D05999  Talotrexin ammonium (USAN)
            D06238  Trimetrexate (USAN/INN)
            D06239  Trimetrexate glucuronate (USAN)
            D06503  Pemetrexed sodium hydrate (JAN)
            D07472  Pemetrexed (INN)
            D10596  Pemetrexed sodium hemipentahydrate (JAN)
            D11352  Pemetrexed tromethamine (USAN)
            D11779  Fosdenopterin (USAN)
            D11780  Fosdenopterin hydrobromide (USAN)
            D12277  Ilofotase alfa (USAN)
DBLINKS     GO: 0046656
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2643  GCH1; GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
            249  ALPL; alkaline phosphatase, biomineralization associated [KO:K01077] [EC:3.1.3.1]
            248  ALPI; alkaline phosphatase, intestinal [KO:K01077] [EC:3.1.3.1]
            250  ALPP; alkaline phosphatase, placental [KO:K01077] [EC:3.1.3.1]
            251  ALPG; alkaline phosphatase, germ cell [KO:K01077] [EC:3.1.3.1]
            1719  DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
            200895  DHFR2; dihydrofolate reductase 2 [KO:K00287] [EC:1.5.1.3]
            2356  FPGS; folylpolyglutamate synthase [KO:K01930] [EC:6.3.2.17]
            8836  GGH; gamma-glutamyl hydrolase [KO:K01307] [EC:3.4.19.9]
            5805  PTS; 6-pyruvoyltetrahydropterin synthase [KO:K01737] [EC:4.2.3.12 4.1.2.50]
            6697  SPR; sepiapterin reductase [KO:K00072] [EC:1.1.1.153]
            231  AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]
            57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
            873  CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            8644  AKR1C3; aldo-keto reductase family 1 member C3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
            5860  QDPR; quinoid dihydropteridine reductase [KO:K00357] [EC:1.5.1.34]
            84105  PCBD2; pterin-4 alpha-carbinolamine dehydratase 2 [KO:K01724] [EC:4.2.1.96]
            5092  PCBD1; pterin-4 alpha-carbinolamine dehydratase 1 [KO:K01724] [EC:4.2.1.96]
            5053  PAH; phenylalanine hydroxylase [KO:K00500] [EC:1.14.16.1]
            7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
            121278  TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
            7166  TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
            4337  MOCS1; molybdenum cofactor synthesis 1 [KO:K20967] [EC:4.1.99.22 4.6.1.17]
            4338  MOCS2; molybdenum cofactor synthesis 2 [KO:K03635] [EC:2.8.1.12]
            10243  GPHN; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
            55034  MOCOS; molybdenum cofactor sulfurase [KO:K15631] [EC:2.8.1.9]
COMPOUND    C00044  GTP
            C00101  Tetrahydrofolate
            C00119  5-Phospho-alpha-D-ribose 1-diphosphate
            C00156  4-Hydroxybenzoate
            C00251  Chorismate
            C00266  Glycolaldehyde
            C00268  Dihydrobiopterin
            C00272  Tetrahydrobiopterin
            C00415  Dihydrofolate
            C00504  Folate
            C00568  4-Aminobenzoate
            C00835  Sepiapterin
            C00921  Dihydropteroate
            C01217  5,6,7,8-Tetrahydromethanopterin
            C01300  6-(Hydroxymethyl)-7,8-dihydropterin
            C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
            C02587  Pyrimidodiazepine
            C02953  7,8-Dihydrobiopterin
            C03541  THF-polyglutamate
            C03684  6-Pyruvoyltetrahydropterin
            C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
            C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
            C04874  7,8-Dihydroneopterin
            C04895  7,8-Dihydroneopterin 3'-triphosphate
            C05922  Formamidopyrimidine nucleoside triphosphate
            C05923  2,5-Diaminopyrimidine nucleoside triphosphate
            C05924  Molybdopterin
            C05925  Dihydroneopterin phosphate
            C05926  Neopterin
            C05927  7,8-Dihydromethanopterin
            C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
            C06313  Biopterin
            C09332  THF-L-glutamate
            C11355  4-Amino-4-deoxychorismate
            C15522  4a-Hydroxytetrahydrobiopterin
            C15996  7-Cyano-7-carbaguanine
            C16675  7-Aminomethyl-7-carbaguanine
            C18237  Molybdoenzyme molybdenum cofactor
            C18239  Precursor Z
            C18802  Tetrahydrosarcinapterin
            C19848  Adenylated molybdopterin
            C19871  Guanylyl molybdenum cofactor
            C20239  6-Carboxy-5,6,7,8-tetrahydropterin
            C20248  7-Carboxy-7-carbaguanine
            C20264  L-threo-Tetrahydrobiopterin
            C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
            C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
            C20566  7,8-Dihydroneopterin 2'-phosphate
            C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
            C21007  5,6,7,8-Tetrahydromonapterin
            C21008  7,8-Dihydromonapterin
            C21065  7,8-Dihydroxanthopterin
            C21094  7,8-Dihydromonapterin 3'-triphosphate
            C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
            C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
            C21485  Cytidylyl molybdenum cofactor
            C21486  Thio-molybdenum cofactor
            C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:19675644
  AUTHORS   Schwarz G, Mendel RR, Ribbe MW
  TITLE     Molybdenum cofactors, enzymes and pathways.
  JOURNAL   Nature 460:839-47 (2009)
            DOI:10.1038/nature08302
REFERENCE   PMID:16632608
  AUTHORS   Hanzelmann P, Schindelin H
  TITLE     Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  JOURNAL   Proc Natl Acad Sci U S A 103:6829-34 (2006)
            DOI:10.1073/pnas.0510711103
REFERENCE   PMID:18092812
  AUTHORS   Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  TITLE     Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  JOURNAL   Biochemistry 47:615-26 (2008)
            DOI:10.1021/bi701734g
REFERENCE   PMID:12571226
  AUTHORS   Wuebbens MM, Rajagopalan KV
  TITLE     Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  JOURNAL   J Biol Chem 278:14523-32 (2003)
            DOI:10.1074/jbc.M300453200
REFERENCE   PMID:21867484
  AUTHORS   Werner ER, Blau N, Thony B
  TITLE     Tetrahydrobiopterin: biochemistry and pathophysiology.
  JOURNAL   Biochem J 438:397-414 (2011)
            DOI:10.1042/BJ20110293
REFERENCE   PMID:12893295
  AUTHORS   Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  TITLE     Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  JOURNAL   Arch Biochem Biophys 416:180-7 (2003)
            DOI:10.1016/S0003-9861(03)00295-9
REFERENCE   PMID:1902669
  AUTHORS   Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  TITLE     Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  JOURNAL   Biochem Biophys Res Commun 175:738-44 (1991)
            DOI:10.1016/0006-291X(91)91628-P
REL_PATHWAY hsa00230  Purine metabolism
            hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            hsa00670  One carbon pool by folate
KO_PATHWAY  ko00790
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